Temporal changes in risk of cardiovascular events in people with newly diagnosed type 2 diabetes with and without cardiovascular disease
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Temporal changes in risk of cardiovascular events in people with newly diagnosed type 2 diabetes with and without cardiovascular disease. / Norgaard, Caroline H.; Starkopf, Liis; Gerds, Thomas A.; Malmborg, Morten; Bonde, Anders N.; Zareini, Bochra; Mills, Elisabeth Helen Anna; Vestergaard, Peter; Wong, Nathan D.; Torp-Pedersen, Christian; Lee, Christina J-Y.
I: Journal of Diabetes and its Complications, Bind 36, Nr. 2, 108126, 2022.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Temporal changes in risk of cardiovascular events in people with newly diagnosed type 2 diabetes with and without cardiovascular disease
AU - Norgaard, Caroline H.
AU - Starkopf, Liis
AU - Gerds, Thomas A.
AU - Malmborg, Morten
AU - Bonde, Anders N.
AU - Zareini, Bochra
AU - Mills, Elisabeth Helen Anna
AU - Vestergaard, Peter
AU - Wong, Nathan D.
AU - Torp-Pedersen, Christian
AU - Lee, Christina J-Y
PY - 2022
Y1 - 2022
N2 - Aims: Examine temporal changes in the risk of cardiovascular events in people with newly diagnosed type 2 diabetes with and without cardiovascular disease (CVD). Methods: 283,600 individuals with newly diagnosed type 2 diabetes and age-, sex-, and CVD-matched controls without diabetes were identified through Danish nationwide registries between 1997 and 2014. Using Cox regression models, we report the standardized absolute 5-year risk of cardiovascular death, myocardial infarction, stroke, and heart failure for people with diabetes and controls. Results: Individuals with newly diagnosed diabetes were at increased risk of cardiovascular events compared to controls. From 1997-2002 to 2009-2014 reductions in cardiovascular events for people with diabetes were: cardiovascular death; 26.5% to 13.8% in people with CVD and from 7.3% to 3.2% in people without CVD, myocardial infarction; 13.1% to 6.5% in people with CVD and from 4.1% to 1.9% in people without CVD, stroke; 14.2% to 8.8% in people with CVD and from 4.9% to 2.2% in people without CVD, and heart failure; 21.0% to 13.8% in people with CVD and from 5.0% to 2.6% in people without CVD. The risk of cardiovascular events declined more among people with diabetes than controls. Conclusions: Newly diagnosed type 2 diabetes was associated with an increased risk of cardiovascular events, and the risk decreased significantly 1997-2014 in both people with and without CVD. Furthermore, the excess risk associated with type 2 diabetes decreased significantly during the study period.
AB - Aims: Examine temporal changes in the risk of cardiovascular events in people with newly diagnosed type 2 diabetes with and without cardiovascular disease (CVD). Methods: 283,600 individuals with newly diagnosed type 2 diabetes and age-, sex-, and CVD-matched controls without diabetes were identified through Danish nationwide registries between 1997 and 2014. Using Cox regression models, we report the standardized absolute 5-year risk of cardiovascular death, myocardial infarction, stroke, and heart failure for people with diabetes and controls. Results: Individuals with newly diagnosed diabetes were at increased risk of cardiovascular events compared to controls. From 1997-2002 to 2009-2014 reductions in cardiovascular events for people with diabetes were: cardiovascular death; 26.5% to 13.8% in people with CVD and from 7.3% to 3.2% in people without CVD, myocardial infarction; 13.1% to 6.5% in people with CVD and from 4.1% to 1.9% in people without CVD, stroke; 14.2% to 8.8% in people with CVD and from 4.9% to 2.2% in people without CVD, and heart failure; 21.0% to 13.8% in people with CVD and from 5.0% to 2.6% in people without CVD. The risk of cardiovascular events declined more among people with diabetes than controls. Conclusions: Newly diagnosed type 2 diabetes was associated with an increased risk of cardiovascular events, and the risk decreased significantly 1997-2014 in both people with and without CVD. Furthermore, the excess risk associated with type 2 diabetes decreased significantly during the study period.
KW - Diabetes mellitus
KW - type 2
KW - Myocardial infarction
KW - Stroke
KW - Heart failure
KW - Cardiovascular disease
KW - MYOCARDIAL-INFARCTION
KW - LOWERING TREATMENT
KW - HEART-DISEASE
KW - MORTALITY
KW - MELLITUS
KW - COMPLICATIONS
KW - OUTCOMES
KW - STROKE
KW - INTERVENTION
KW - REGISTRATION
U2 - 10.1016/j.jdiacomp.2022.108126
DO - 10.1016/j.jdiacomp.2022.108126
M3 - Journal article
C2 - 35033442
VL - 36
JO - Journal of Diabetes and its Complications
JF - Journal of Diabetes and its Complications
SN - 1056-8727
IS - 2
M1 - 108126
ER -
ID: 297360478