Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein. / Salanti, Ali; Clausen, Thomas M; Agerbæk, Mette Ø; Al Nakouzi, Nader; Dahlbäck, Madeleine; Oo, Htoo Z; Lee, Sherry; Gustavsson, Tobias; Rich, Jamie R; Hedberg, Bradley J; Mao, Yang; Barington, Line; Pereira, Marina A; LoBello, Janine; Endo, Makoto; Fazli, Ladan; Soden, Jo; Wang, Chris K; Sander, Adam F; Dagil, Robert; Thrane, Susan; Holst, Peter J; Meng, Le; Favero, Francesco; Weiss, Glen J; Nielsen, Morten A; Freeth, Jim; Nielsen, Torsten O; Zaia, Joseph; Tran, Nhan L; Trent, Jeff; Babcook, John S; Theander, Thor G; Sorensen, Poul H; Daugaard, Mads.
I: Cancer Cell, Bind 28, Nr. 4, 2015, s. 500-14.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Targeting Human Cancer by a Glycosaminoglycan Binding Malaria Protein
AU - Salanti, Ali
AU - Clausen, Thomas M
AU - Agerbæk, Mette Ø
AU - Al Nakouzi, Nader
AU - Dahlbäck, Madeleine
AU - Oo, Htoo Z
AU - Lee, Sherry
AU - Gustavsson, Tobias
AU - Rich, Jamie R
AU - Hedberg, Bradley J
AU - Mao, Yang
AU - Barington, Line
AU - Pereira, Marina A
AU - LoBello, Janine
AU - Endo, Makoto
AU - Fazli, Ladan
AU - Soden, Jo
AU - Wang, Chris K
AU - Sander, Adam F
AU - Dagil, Robert
AU - Thrane, Susan
AU - Holst, Peter J
AU - Meng, Le
AU - Favero, Francesco
AU - Weiss, Glen J
AU - Nielsen, Morten A
AU - Freeth, Jim
AU - Nielsen, Torsten O
AU - Zaia, Joseph
AU - Tran, Nhan L
AU - Trent, Jeff
AU - Babcook, John S
AU - Theander, Thor G
AU - Sorensen, Poul H
AU - Daugaard, Mads
N1 - Copyright © 2015 Elsevier Inc. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Plasmodium falciparum engineer infected erythrocytes to present the malarial protein, VAR2CSA, which binds a distinct type chondroitin sulfate (CS) exclusively expressed in the placenta. Here, we show that the same CS modification is present on a high proportion of malignant cells and that it can be specifically targeted by recombinant VAR2CSA (rVAR2). In tumors, placental-like CS chains are linked to a limited repertoire of cancer-associated proteoglycans including CD44 and CSPG4. The rVAR2 protein localizes to tumors in vivo and rVAR2 fused to diphtheria toxin or conjugated to hemiasterlin compounds strongly inhibits in vivo tumor cell growth and metastasis. Our data demonstrate how an evolutionarily refined parasite-derived protein can be exploited to target a common, but complex, malignancy-associated glycosaminoglycan modification.
AB - Plasmodium falciparum engineer infected erythrocytes to present the malarial protein, VAR2CSA, which binds a distinct type chondroitin sulfate (CS) exclusively expressed in the placenta. Here, we show that the same CS modification is present on a high proportion of malignant cells and that it can be specifically targeted by recombinant VAR2CSA (rVAR2). In tumors, placental-like CS chains are linked to a limited repertoire of cancer-associated proteoglycans including CD44 and CSPG4. The rVAR2 protein localizes to tumors in vivo and rVAR2 fused to diphtheria toxin or conjugated to hemiasterlin compounds strongly inhibits in vivo tumor cell growth and metastasis. Our data demonstrate how an evolutionarily refined parasite-derived protein can be exploited to target a common, but complex, malignancy-associated glycosaminoglycan modification.
U2 - 10.1016/j.ccell.2015.09.003
DO - 10.1016/j.ccell.2015.09.003
M3 - Journal article
C2 - 26461094
VL - 28
SP - 500
EP - 514
JO - Cancer Cell
JF - Cancer Cell
SN - 1535-6108
IS - 4
ER -
ID: 147243458