Targeting BKCa Channels in Migraine: Rationale and Perspectives

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Targeting BKCa Channels in Migraine : Rationale and Perspectives. / Al-Karagholi, Mohammad Al-Mahdi; Gram, Christian; Nielsen, Cherie Amalie Waldorff; Ashina, Messoud.

I: CNS Drugs, Bind 34, Nr. 4, 04.2020, s. 325-335.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Al-Karagholi, MA-M, Gram, C, Nielsen, CAW & Ashina, M 2020, 'Targeting BKCa Channels in Migraine: Rationale and Perspectives', CNS Drugs, bind 34, nr. 4, s. 325-335. https://doi.org/10.1007/s40263-020-00706-8

APA

Al-Karagholi, M. A-M., Gram, C., Nielsen, C. A. W., & Ashina, M. (2020). Targeting BKCa Channels in Migraine: Rationale and Perspectives. CNS Drugs, 34(4), 325-335. https://doi.org/10.1007/s40263-020-00706-8

Vancouver

Al-Karagholi MA-M, Gram C, Nielsen CAW, Ashina M. Targeting BKCa Channels in Migraine: Rationale and Perspectives. CNS Drugs. 2020 apr.;34(4):325-335. https://doi.org/10.1007/s40263-020-00706-8

Author

Al-Karagholi, Mohammad Al-Mahdi ; Gram, Christian ; Nielsen, Cherie Amalie Waldorff ; Ashina, Messoud. / Targeting BKCa Channels in Migraine : Rationale and Perspectives. I: CNS Drugs. 2020 ; Bind 34, Nr. 4. s. 325-335.

Bibtex

@article{ff408967c0054c6ba2993a82d67a73aa,
title = "Targeting BKCa Channels in Migraine: Rationale and Perspectives",
abstract = "Large (big)-conductance calcium-activated potassium (BKCa) channels are expressed in migraine-related structures such as the cranial arteries, trigeminal ganglion and trigeminal spinal nucleus, and they play a substantial role in vascular tonus and neuronal excitability. Using synthetic BKCa channels openers was associated with headache as a frequent adverse effect in healthy volunteers. Additionally, BKCa channels are downstream molecules in migraine signalling pathways that are activated by several compounds known to provoke migraine, including calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP) and glyceryl trinitrate (GTN). Also, there is a high affinity and a close coupling between BKCa channels and ATP-sensitive potassium (KATP) channels, the role of which has recently been established in migraine pathophysiology. These observations raise the question as to whether direct BKCa channel activation can provoke migraine in migraine patients, and whether the BKCa channel could be a potential novel anti-migraine target. Hence, randomized and placebo-controlled clinical studies on BKCa channel openers or blockers in migraine patients are needed.",
author = "Al-Karagholi, {Mohammad Al-Mahdi} and Christian Gram and Nielsen, {Cherie Amalie Waldorff} and Messoud Ashina",
year = "2020",
month = apr,
doi = "10.1007/s40263-020-00706-8",
language = "English",
volume = "34",
pages = "325--335",
journal = "CNS Drugs",
issn = "1172-7047",
publisher = "Adis International Ltd",
number = "4",

}

RIS

TY - JOUR

T1 - Targeting BKCa Channels in Migraine

T2 - Rationale and Perspectives

AU - Al-Karagholi, Mohammad Al-Mahdi

AU - Gram, Christian

AU - Nielsen, Cherie Amalie Waldorff

AU - Ashina, Messoud

PY - 2020/4

Y1 - 2020/4

N2 - Large (big)-conductance calcium-activated potassium (BKCa) channels are expressed in migraine-related structures such as the cranial arteries, trigeminal ganglion and trigeminal spinal nucleus, and they play a substantial role in vascular tonus and neuronal excitability. Using synthetic BKCa channels openers was associated with headache as a frequent adverse effect in healthy volunteers. Additionally, BKCa channels are downstream molecules in migraine signalling pathways that are activated by several compounds known to provoke migraine, including calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP) and glyceryl trinitrate (GTN). Also, there is a high affinity and a close coupling between BKCa channels and ATP-sensitive potassium (KATP) channels, the role of which has recently been established in migraine pathophysiology. These observations raise the question as to whether direct BKCa channel activation can provoke migraine in migraine patients, and whether the BKCa channel could be a potential novel anti-migraine target. Hence, randomized and placebo-controlled clinical studies on BKCa channel openers or blockers in migraine patients are needed.

AB - Large (big)-conductance calcium-activated potassium (BKCa) channels are expressed in migraine-related structures such as the cranial arteries, trigeminal ganglion and trigeminal spinal nucleus, and they play a substantial role in vascular tonus and neuronal excitability. Using synthetic BKCa channels openers was associated with headache as a frequent adverse effect in healthy volunteers. Additionally, BKCa channels are downstream molecules in migraine signalling pathways that are activated by several compounds known to provoke migraine, including calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP) and glyceryl trinitrate (GTN). Also, there is a high affinity and a close coupling between BKCa channels and ATP-sensitive potassium (KATP) channels, the role of which has recently been established in migraine pathophysiology. These observations raise the question as to whether direct BKCa channel activation can provoke migraine in migraine patients, and whether the BKCa channel could be a potential novel anti-migraine target. Hence, randomized and placebo-controlled clinical studies on BKCa channel openers or blockers in migraine patients are needed.

U2 - 10.1007/s40263-020-00706-8

DO - 10.1007/s40263-020-00706-8

M3 - Journal article

C2 - 32060729

VL - 34

SP - 325

EP - 335

JO - CNS Drugs

JF - CNS Drugs

SN - 1172-7047

IS - 4

ER -

ID: 252106498