Tailor-Made Doses of Pharmaceuticals by Tunable Modular Design: A Case Study on Tapering Antidepressant Medication

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An abrupt cessation of antidepressant medication can be challenging due to the appearance of withdrawal symptoms. A slow hyperbolic tapering of an antidepressant, such as citalopram hydrobromide (CHB), can mitigate the withdrawal syndrome. However, there are no viable dosage forms on the market to implement the tapering scheme. A solution using a tunable modular design (TMD) approach to produce flexible and accurate doses of CHB is proposed. This design consists of two parts: 1) a module with a fixed amount of preloaded CHB in a freeze-dried polymer matrix, and 2) fine-tuning the CHB dose by inkjet printing. A noncontact food-grade printer, used for the first time for printing pharmaceuticals, is modified to allow for accurate printing of the highly concentrated CHB ink on the porous CHB-free or CHB-preloaded modules. The produced modules with submilligram precision are bench-marked with commercially available CHB tablets that are manually divided. The TMD covers the entire range of doses needed for the tapering (0.5–23.8 mg). The greatest variance is 13% and 88% when comparing the TMD and self-tapering, respectively. Self-tapering is proven inaccurate and showcases the need for the TMD to make available accurate and personalized doses to wean off treatment with CHB.

OriginalsprogEngelsk
TidsskriftAdvanced Materials
ISSN0935-9648
DOI
StatusAccepteret/In press - 2024

Bibliografisk note

Funding Information:
The M.Sc. students Natalia Stati, Tamara Mohammed Alsalty, and Batoul Kheder Arrag are acknowledged for laboratory assistance. The Ph.D. student Wuzhong He is thanked for performing the rheological characterization and surface tension measurements of standard inks used in the food\u2010grade inkjet printer. The authors acknowledged the funding from University of Copenhagen, the UCPH Data+ pool Strategy 2023 funds, and NordForsk (Nordic University Hub project #85352 Nordic POP, Patient\u2010Oriented Products). Furthermore, the author expresses the sincerest gratitude to the team of Primera Technology for technical assistance with their food\u2010grade printer.

Publisher Copyright:
© 2024 The Authors. Advanced Materials published by Wiley-VCH GmbH.

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