Systemic oxidative DNA and RNA damage are not increased during early phases of psychosis: A case control study
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Systemic oxidative DNA and RNA damage are not increased during early phases of psychosis : A case control study. / Nordholm, Dorte; Poulsen, Henrik Enghusen; Hjorthøj, Carsten; Randers, Lasse; Nielsen, Mette Ø.; Wulff, Sanne; Krakauer, Kristine; Nørbak-Emig, Henrik; Henriksen, Trine; Glenthøj, Birte; Nordentoft, Merete.
I: Psychiatry Research, Bind 241, 30.07.2016, s. 201-6.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Systemic oxidative DNA and RNA damage are not increased during early phases of psychosis
T2 - A case control study
AU - Nordholm, Dorte
AU - Poulsen, Henrik Enghusen
AU - Hjorthøj, Carsten
AU - Randers, Lasse
AU - Nielsen, Mette Ø.
AU - Wulff, Sanne
AU - Krakauer, Kristine
AU - Nørbak-Emig, Henrik
AU - Henriksen, Trine
AU - Glenthøj, Birte
AU - Nordentoft, Merete
N1 - Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.
PY - 2016/7/30
Y1 - 2016/7/30
N2 - It has been suggested that patients with schizophrenia develop higher levels of oxidative stress, which may contribute to deteriorating mental illness. In order to examine oxidative stress in the early stages of severe mental illness, we examined the levels of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, perceived stress and recent life events in patients at ultra high-risk (UHR) of developing psychosis, in antipsychotic naïve patients with first-episode schizophrenia (FES), and in healthy controls. We included 41 UHR patients, 35 FES patients, and 29 healthy controls. There was no difference in the level of DNA/RNA oxidative damage between UHR patients and FES patients compared with healthy controls. We found no association between levels of DNA/RNA oxidative damage and perceived stress/life events. Based on the results, we suggest that DNA and RNA oxidative markers are not increased during the early stages of illness, but further longitudinal studies in first-episode psychosis should be carried out to examine whether DNA and RNA oxidative damage are potential markers of severe illness.
AB - It has been suggested that patients with schizophrenia develop higher levels of oxidative stress, which may contribute to deteriorating mental illness. In order to examine oxidative stress in the early stages of severe mental illness, we examined the levels of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, perceived stress and recent life events in patients at ultra high-risk (UHR) of developing psychosis, in antipsychotic naïve patients with first-episode schizophrenia (FES), and in healthy controls. We included 41 UHR patients, 35 FES patients, and 29 healthy controls. There was no difference in the level of DNA/RNA oxidative damage between UHR patients and FES patients compared with healthy controls. We found no association between levels of DNA/RNA oxidative damage and perceived stress/life events. Based on the results, we suggest that DNA and RNA oxidative markers are not increased during the early stages of illness, but further longitudinal studies in first-episode psychosis should be carried out to examine whether DNA and RNA oxidative damage are potential markers of severe illness.
KW - Journal Article
U2 - 10.1016/j.psychres.2016.04.062
DO - 10.1016/j.psychres.2016.04.062
M3 - Journal article
C2 - 27183105
VL - 241
SP - 201
EP - 206
JO - Psychiatry Research
JF - Psychiatry Research
SN - 0165-1781
ER -
ID: 174836229