Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Novel pyrazolyl-2,4-thiazolidinediones were prepared via the reaction of appropriate pyrazolecarboxaldehydes with 2,4-thiazolidinediones and substituted benzyl-2,4-thiazolidinediones. The resultant compounds were first evaluated for their anti-inflammatory and neuroprotective properties in vitro. The active compounds were further studied in vivo by using the formalin-induced paw edema and the turpentine oil-induced granuloma pouch bioassays. We identified four novel compounds that showed protective effects in vitro at non-toxic concentrations, and were also effective in the animal models of acute and sub-acute inflammation.
Originalsprog | Engelsk |
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Tidsskrift | Bioorganic & Medicinal Chemistry |
Vol/bind | 18 |
Udgave nummer | 5 |
Sider (fra-til) | 2019-28 |
Antal sider | 10 |
ISSN | 0968-0896 |
DOI | |
Status | Udgivet - 1 mar. 2010 |
Eksternt udgivet | Ja |
ID: 236610080