Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics. / Dagnegård, Hanna H.; Bekke, Kirstine; Kolseth, Solveig M.; Glaser, Natalie; Wallén, Christoffer; El-Hamamsy, Ismail; Vidisson, Kristjan O.; Lie, Asbjørn S.; Valentin, Jan B.; Sartipy, Ulrik; Haaverstad, Rune; Vanky, Farkas; Lefebvre, Laurence; Gudbjartsson, Tomas; Johnsen, Søren P.; Søndergaard, Lars; Thyregod, Gustav H.; Lund, Jens T.; Ihlemann, Nikolaj; Smerup, Morten H.

I: Journal of Thoracic and Cardiovascular Surgery, Bind 164, Nr. 6, 2022, s. 1712-1724.e10.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Dagnegård, HH, Bekke, K, Kolseth, SM, Glaser, N, Wallén, C, El-Hamamsy, I, Vidisson, KO, Lie, AS, Valentin, JB, Sartipy, U, Haaverstad, R, Vanky, F, Lefebvre, L, Gudbjartsson, T, Johnsen, SP, Søndergaard, L, Thyregod, GH, Lund, JT, Ihlemann, N & Smerup, MH 2022, 'Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics', Journal of Thoracic and Cardiovascular Surgery, bind 164, nr. 6, s. 1712-1724.e10. https://doi.org/10.1016/j.jtcvs.2021.07.011

APA

Dagnegård, H. H., Bekke, K., Kolseth, S. M., Glaser, N., Wallén, C., El-Hamamsy, I., Vidisson, K. O., Lie, A. S., Valentin, J. B., Sartipy, U., Haaverstad, R., Vanky, F., Lefebvre, L., Gudbjartsson, T., Johnsen, S. P., Søndergaard, L., Thyregod, G. H., Lund, J. T., Ihlemann, N., & Smerup, M. H. (2022). Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics. Journal of Thoracic and Cardiovascular Surgery, 164(6), 1712-1724.e10. https://doi.org/10.1016/j.jtcvs.2021.07.011

Vancouver

Dagnegård HH, Bekke K, Kolseth SM, Glaser N, Wallén C, El-Hamamsy I o.a. Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics. Journal of Thoracic and Cardiovascular Surgery. 2022;164(6):1712-1724.e10. https://doi.org/10.1016/j.jtcvs.2021.07.011

Author

Dagnegård, Hanna H. ; Bekke, Kirstine ; Kolseth, Solveig M. ; Glaser, Natalie ; Wallén, Christoffer ; El-Hamamsy, Ismail ; Vidisson, Kristjan O. ; Lie, Asbjørn S. ; Valentin, Jan B. ; Sartipy, Ulrik ; Haaverstad, Rune ; Vanky, Farkas ; Lefebvre, Laurence ; Gudbjartsson, Tomas ; Johnsen, Søren P. ; Søndergaard, Lars ; Thyregod, Gustav H. ; Lund, Jens T. ; Ihlemann, Nikolaj ; Smerup, Morten H. / Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics. I: Journal of Thoracic and Cardiovascular Surgery. 2022 ; Bind 164, Nr. 6. s. 1712-1724.e10.

Bibtex

@article{1495835540544623b917415c1cd45e8f,

title = "Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics",

abstract = "Objectives: Our objective was to examine intermediate-term survival and reinterventions in unselected patients, stratified according to indication, who received a Freestyle (Medtronic Inc, Minneapolis, Minn) bioprosthesis as a full aortic root replacement. Methods: Data from medical records were retrospectively collected for patients who had aortic root replacement using Freestyle bioprostheses between 1999 and 2018 at 6 North-Atlantic centers. Survival status was extracted from national registries and results stratified according to indication for surgery. Results: We included 1030 implantations in 1008 patients with elective indications for surgery: aneurysm (39.8%), small root (8.3%), and other (13.8%), and urgent/emergent indications: endocarditis (26.7%) and Stanford type A aortic dissection (11.4%). Across indications, 46.3% were nonelective cases and 34.0% were reoperations. Median age was 66.0 (interquartile range, 58.0-71.8) years and median follow-up was 5.0 (interquartile range, 2.6-7.9) years. Thirty-day mortality varied from 2.9% to 27.4% depending on indication. Intermediate survival for 90-day survivors with elective indications were not different from the general population standardized for age and sex (P = .95, 83, and .16 for aneurysms, small roots, and other, respectively). In contrast, patients with endocarditis and type A dissection had excess mortality (P < .001). Freedom from valve reinterventions was 95.0% and 94.4% at 5 and 8 years, respectively. In all, 52 patients (5.2%) underwent reinterventions, most because of endocarditis. Conclusions: At intermediate term follow-up this retrospective study provides further support for the use of the Freestyle bioprosthesis in the real-world setting of diverse, complex, and often high-risk aortic root replacement and suggests that outcome is determined by patient and disease, rather than by prosthesis, characteristics.",

keywords = "aortic root replacement, endocarditis, full root bioprosthesis, reinterventions, survival, type A dissections",

author = "Dagneg{\aa}rd, {Hanna H.} and Kirstine Bekke and Kolseth, {Solveig M.} and Natalie Glaser and Christoffer Wall{\'e}n and Ismail El-Hamamsy and Vidisson, {Kristjan O.} and Lie, {Asbj{\o}rn S.} and Valentin, {Jan B.} and Ulrik Sartipy and Rune Haaverstad and Farkas Vanky and Laurence Lefebvre and Tomas Gudbjartsson and Johnsen, {S{\o}ren P.} and Lars S{\o}ndergaard and Thyregod, {Gustav H.} and Lund, {Jens T.} and Nikolaj Ihlemann and Smerup, {Morten H.}",

note = "Publisher Copyright: {\textcopyright} 2021 The Authors",

year = "2022",

doi = "10.1016/j.jtcvs.2021.07.011",

language = "English",

volume = "164",

pages = "1712--1724.e10",

journal = "Journal of Thoracic and Cardiovascular Surgery",

issn = "0022-5223",

publisher = "Mosby Inc.",

number = "6",

}

RIS

TY - JOUR

T1 - Survival after aortic root replacement with a stentless xenograft is determined by patient characteristics

AU - Dagnegård, Hanna H.

AU - Bekke, Kirstine

AU - Kolseth, Solveig M.

AU - Glaser, Natalie

AU - Wallén, Christoffer

AU - El-Hamamsy, Ismail

AU - Vidisson, Kristjan O.

AU - Lie, Asbjørn S.

AU - Valentin, Jan B.

AU - Sartipy, Ulrik

AU - Haaverstad, Rune

AU - Vanky, Farkas

AU - Lefebvre, Laurence

AU - Gudbjartsson, Tomas

AU - Johnsen, Søren P.

AU - Søndergaard, Lars

AU - Thyregod, Gustav H.

AU - Lund, Jens T.

AU - Ihlemann, Nikolaj

AU - Smerup, Morten H.

PY - 2022

Y1 - 2022

N2 - Objectives: Our objective was to examine intermediate-term survival and reinterventions in unselected patients, stratified according to indication, who received a Freestyle (Medtronic Inc, Minneapolis, Minn) bioprosthesis as a full aortic root replacement. Methods: Data from medical records were retrospectively collected for patients who had aortic root replacement using Freestyle bioprostheses between 1999 and 2018 at 6 North-Atlantic centers. Survival status was extracted from national registries and results stratified according to indication for surgery. Results: We included 1030 implantations in 1008 patients with elective indications for surgery: aneurysm (39.8%), small root (8.3%), and other (13.8%), and urgent/emergent indications: endocarditis (26.7%) and Stanford type A aortic dissection (11.4%). Across indications, 46.3% were nonelective cases and 34.0% were reoperations. Median age was 66.0 (interquartile range, 58.0-71.8) years and median follow-up was 5.0 (interquartile range, 2.6-7.9) years. Thirty-day mortality varied from 2.9% to 27.4% depending on indication. Intermediate survival for 90-day survivors with elective indications were not different from the general population standardized for age and sex (P = .95, 83, and .16 for aneurysms, small roots, and other, respectively). In contrast, patients with endocarditis and type A dissection had excess mortality (P < .001). Freedom from valve reinterventions was 95.0% and 94.4% at 5 and 8 years, respectively. In all, 52 patients (5.2%) underwent reinterventions, most because of endocarditis. Conclusions: At intermediate term follow-up this retrospective study provides further support for the use of the Freestyle bioprosthesis in the real-world setting of diverse, complex, and often high-risk aortic root replacement and suggests that outcome is determined by patient and disease, rather than by prosthesis, characteristics.

AB - Objectives: Our objective was to examine intermediate-term survival and reinterventions in unselected patients, stratified according to indication, who received a Freestyle (Medtronic Inc, Minneapolis, Minn) bioprosthesis as a full aortic root replacement. Methods: Data from medical records were retrospectively collected for patients who had aortic root replacement using Freestyle bioprostheses between 1999 and 2018 at 6 North-Atlantic centers. Survival status was extracted from national registries and results stratified according to indication for surgery. Results: We included 1030 implantations in 1008 patients with elective indications for surgery: aneurysm (39.8%), small root (8.3%), and other (13.8%), and urgent/emergent indications: endocarditis (26.7%) and Stanford type A aortic dissection (11.4%). Across indications, 46.3% were nonelective cases and 34.0% were reoperations. Median age was 66.0 (interquartile range, 58.0-71.8) years and median follow-up was 5.0 (interquartile range, 2.6-7.9) years. Thirty-day mortality varied from 2.9% to 27.4% depending on indication. Intermediate survival for 90-day survivors with elective indications were not different from the general population standardized for age and sex (P = .95, 83, and .16 for aneurysms, small roots, and other, respectively). In contrast, patients with endocarditis and type A dissection had excess mortality (P < .001). Freedom from valve reinterventions was 95.0% and 94.4% at 5 and 8 years, respectively. In all, 52 patients (5.2%) underwent reinterventions, most because of endocarditis. Conclusions: At intermediate term follow-up this retrospective study provides further support for the use of the Freestyle bioprosthesis in the real-world setting of diverse, complex, and often high-risk aortic root replacement and suggests that outcome is determined by patient and disease, rather than by prosthesis, characteristics.

KW - aortic root replacement

KW - endocarditis

KW - full root bioprosthesis

KW - reinterventions

KW - survival

KW - type A dissections

U2 - 10.1016/j.jtcvs.2021.07.011

DO - 10.1016/j.jtcvs.2021.07.011

M3 - Journal article

C2 - 34452760

AN - SCOPUS:85113240826

VL - 164

SP - 1712-1724.e10

JO - Journal of Thoracic and Cardiovascular Surgery

JF - Journal of Thoracic and Cardiovascular Surgery

SN - 0022-5223

IS - 6

ER -

ID: 279627961