Survey of diagnostic and treatment practices for multiple sclerosis in Europe
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Survey of diagnostic and treatment practices for multiple sclerosis in Europe. / Fernández, O; Delvecchio, M; Edan, G; Fredrikson, S; Gionvannoni, G; Hartung, H-P; Havrdova, E; Kappos, L; Pozzilli, C; Soerensen, P S; Tackenberg, B; Vermersch, P; Comi, G.
I: European Journal of Neurology, Bind 24, Nr. 3, 2017, s. 516-522.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Survey of diagnostic and treatment practices for multiple sclerosis in Europe
AU - Fernández, O
AU - Delvecchio, M
AU - Edan, G
AU - Fredrikson, S
AU - Gionvannoni, G
AU - Hartung, H-P
AU - Havrdova, E
AU - Kappos, L
AU - Pozzilli, C
AU - Soerensen, P S
AU - Tackenberg, B
AU - Vermersch, P
AU - Comi, G
N1 - © 2017 EAN.
PY - 2017
Y1 - 2017
N2 - BACKGROUND AND PURPOSE: Up-to-date information is needed on the extent to which neurologists treating multiple sclerosis (MS) in Europe are integrating rapidly evolving diagnostic criteria, disease-modifying therapies and recommendations for monitoring disease activity into their clinical practice.METHODS: A steering committee of MS neurologists used a modified Delphi process to develop case- and practice-based questions for two sequential surveys distributed to MS neurologists throughout Europe. Case-based questions were developed for radiologically isolated syndrome (RIS), clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS) and RRMS with breakthrough disease.RESULTS: Multiple sclerosis neurologists from 11 European countries responded to survey 1 (n = 233) and survey 2 (n = 171). Respondents agreed that they would not treat the patients in the RIS or CIS cases but would treat a patient with a relatively mild form of RRMS. Choice of treatment was evenly distributed among first-line injectables and oral treatments for mild RRMS, and moved to second-line treatment as the RRMS case increased in severity. Additional results on RRMS with breakthrough disease are presented.CONCLUSIONS: Although there was general agreement on some aspects of treatment, responses to other management and clinical practice questions varied considerably. These results, which reflect current clinical practice patterns, highlight the need for additional MS treatment education and awareness and may help inform the development of MS practice guidelines in Europe.
AB - BACKGROUND AND PURPOSE: Up-to-date information is needed on the extent to which neurologists treating multiple sclerosis (MS) in Europe are integrating rapidly evolving diagnostic criteria, disease-modifying therapies and recommendations for monitoring disease activity into their clinical practice.METHODS: A steering committee of MS neurologists used a modified Delphi process to develop case- and practice-based questions for two sequential surveys distributed to MS neurologists throughout Europe. Case-based questions were developed for radiologically isolated syndrome (RIS), clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS) and RRMS with breakthrough disease.RESULTS: Multiple sclerosis neurologists from 11 European countries responded to survey 1 (n = 233) and survey 2 (n = 171). Respondents agreed that they would not treat the patients in the RIS or CIS cases but would treat a patient with a relatively mild form of RRMS. Choice of treatment was evenly distributed among first-line injectables and oral treatments for mild RRMS, and moved to second-line treatment as the RRMS case increased in severity. Additional results on RRMS with breakthrough disease are presented.CONCLUSIONS: Although there was general agreement on some aspects of treatment, responses to other management and clinical practice questions varied considerably. These results, which reflect current clinical practice patterns, highlight the need for additional MS treatment education and awareness and may help inform the development of MS practice guidelines in Europe.
KW - Adult
KW - Delphi Technique
KW - Disease Progression
KW - Europe
KW - Female
KW - Health Care Surveys
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Multiple Sclerosis/diagnosis
KW - Multiple Sclerosis, Relapsing-Remitting/diagnosis
KW - Neurologists
KW - Spinal Puncture
KW - Surveys and Questionnaires
U2 - 10.1111/ene.13236
DO - 10.1111/ene.13236
M3 - Journal article
C2 - 28139062
VL - 24
SP - 516
EP - 522
JO - European Journal of Neurology
JF - European Journal of Neurology
SN - 1351-5101
IS - 3
ER -
ID: 195162038