Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation

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Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation. / Mangner, Norman; del Val, David; Abdel-Wahab, Mohamed; Crusius, Lisa; Durand, Eric; Ihlemann, Nikolaj; Urena, Marina; Pellegrini, Costanza; Giannini, Francesco; Gasior, Tomasz; Wojakowski, Wojtek; Landt, Martin; Auffret, Vincent; Sinning, Jan Malte; Cheema, Asim N.; Nombela-Franco, Luis; Chamandi, Chekrallah; Campelo-Parada, Francisco; Munoz-Garcia, Erika; Herrmann, Howard C.; Testa, Luca; Kim, Won-Keun; Castillo, Juan Carlos; Alperi, Alberto; Tchetche, Didier; Bartorelli, Antonio L.; Kapadia, Samir; Stortecky, Stefan; Amat-Santos, Ignacio; Wijeysundera, Harindra C.; Lisko, John; Gutierrez-Ibanes, Enrique; Serra, Vicenc; Salido, Luisa; Alkhodair, Abdullah; Livi, Ugolino; Chakravarty, Tarun; Lerakis, Stamatios; Vilalta, Victoria; Regueiro, Ander; Romaguera, Rafael; Kappert, Utz; Barbanti, Marco; Masson, Jean-Bernard; Maes, Frederic; Fiorina, Claudia; Miceli, Antonio; Kodali, Susheel; Ribeiro, Henrique B.; Mangione, Jose Armando; de Brito, Fabio Sandoli; Dato, Guglielmo Mario Actis; Rosato, Francesco; Ferreira, Maria-Cristina; de Lima, Valter Correia; Colafranceschi, Alexandre Siciliano; Abizaid, Alexandre; Marino, Marcos Antonio; Esteves, Vinicius; Andrea, Julio; Godinho, Roger R.; Alfonso, Fernando; Eltchaninoff, Helene; Sondergaard, Lars; Himbert, Dominique; Husser, Oliver; Latib, Azeem; Le Breton, Herve; Servoz, Clement; Pascual, Isaac; Siddiqui, Saif; Olivares, Paolo; Hernandez-Antolin, Rosana; Webb, John G.; Sponga, Sandro; Makkar, Raj; Kini, Annapoorna S.; Boukhris, Marouane; Gervais, Philippe; Cote, Melanie; Holzhey, David; Linke, Axel; Rodes-Cabau, Josep.

I: Journal of the American College of Cardiology, Bind 79, Nr. 8, 2022, s. 772-785.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mangner, N, del Val, D, Abdel-Wahab, M, Crusius, L, Durand, E, Ihlemann, N, Urena, M, Pellegrini, C, Giannini, F, Gasior, T, Wojakowski, W, Landt, M, Auffret, V, Sinning, JM, Cheema, AN, Nombela-Franco, L, Chamandi, C, Campelo-Parada, F, Munoz-Garcia, E, Herrmann, HC, Testa, L, Kim, W-K, Castillo, JC, Alperi, A, Tchetche, D, Bartorelli, AL, Kapadia, S, Stortecky, S, Amat-Santos, I, Wijeysundera, HC, Lisko, J, Gutierrez-Ibanes, E, Serra, V, Salido, L, Alkhodair, A, Livi, U, Chakravarty, T, Lerakis, S, Vilalta, V, Regueiro, A, Romaguera, R, Kappert, U, Barbanti, M, Masson, J-B, Maes, F, Fiorina, C, Miceli, A, Kodali, S, Ribeiro, HB, Mangione, JA, de Brito, FS, Dato, GMA, Rosato, F, Ferreira, M-C, de Lima, VC, Colafranceschi, AS, Abizaid, A, Marino, MA, Esteves, V, Andrea, J, Godinho, RR, Alfonso, F, Eltchaninoff, H, Sondergaard, L, Himbert, D, Husser, O, Latib, A, Le Breton, H, Servoz, C, Pascual, I, Siddiqui, S, Olivares, P, Hernandez-Antolin, R, Webb, JG, Sponga, S, Makkar, R, Kini, AS, Boukhris, M, Gervais, P, Cote, M, Holzhey, D, Linke, A & Rodes-Cabau, J 2022, 'Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation', Journal of the American College of Cardiology, bind 79, nr. 8, s. 772-785. https://doi.org/10.1016/j.jacc.2021.11.056

APA

Mangner, N., del Val, D., Abdel-Wahab, M., Crusius, L., Durand, E., Ihlemann, N., Urena, M., Pellegrini, C., Giannini, F., Gasior, T., Wojakowski, W., Landt, M., Auffret, V., Sinning, J. M., Cheema, A. N., Nombela-Franco, L., Chamandi, C., Campelo-Parada, F., Munoz-Garcia, E., ... Rodes-Cabau, J. (2022). Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation. Journal of the American College of Cardiology, 79(8), 772-785. https://doi.org/10.1016/j.jacc.2021.11.056

Vancouver

Mangner N, del Val D, Abdel-Wahab M, Crusius L, Durand E, Ihlemann N o.a. Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation. Journal of the American College of Cardiology. 2022;79(8):772-785. https://doi.org/10.1016/j.jacc.2021.11.056

Author

Mangner, Norman ; del Val, David ; Abdel-Wahab, Mohamed ; Crusius, Lisa ; Durand, Eric ; Ihlemann, Nikolaj ; Urena, Marina ; Pellegrini, Costanza ; Giannini, Francesco ; Gasior, Tomasz ; Wojakowski, Wojtek ; Landt, Martin ; Auffret, Vincent ; Sinning, Jan Malte ; Cheema, Asim N. ; Nombela-Franco, Luis ; Chamandi, Chekrallah ; Campelo-Parada, Francisco ; Munoz-Garcia, Erika ; Herrmann, Howard C. ; Testa, Luca ; Kim, Won-Keun ; Castillo, Juan Carlos ; Alperi, Alberto ; Tchetche, Didier ; Bartorelli, Antonio L. ; Kapadia, Samir ; Stortecky, Stefan ; Amat-Santos, Ignacio ; Wijeysundera, Harindra C. ; Lisko, John ; Gutierrez-Ibanes, Enrique ; Serra, Vicenc ; Salido, Luisa ; Alkhodair, Abdullah ; Livi, Ugolino ; Chakravarty, Tarun ; Lerakis, Stamatios ; Vilalta, Victoria ; Regueiro, Ander ; Romaguera, Rafael ; Kappert, Utz ; Barbanti, Marco ; Masson, Jean-Bernard ; Maes, Frederic ; Fiorina, Claudia ; Miceli, Antonio ; Kodali, Susheel ; Ribeiro, Henrique B. ; Mangione, Jose Armando ; de Brito, Fabio Sandoli ; Dato, Guglielmo Mario Actis ; Rosato, Francesco ; Ferreira, Maria-Cristina ; de Lima, Valter Correia ; Colafranceschi, Alexandre Siciliano ; Abizaid, Alexandre ; Marino, Marcos Antonio ; Esteves, Vinicius ; Andrea, Julio ; Godinho, Roger R. ; Alfonso, Fernando ; Eltchaninoff, Helene ; Sondergaard, Lars ; Himbert, Dominique ; Husser, Oliver ; Latib, Azeem ; Le Breton, Herve ; Servoz, Clement ; Pascual, Isaac ; Siddiqui, Saif ; Olivares, Paolo ; Hernandez-Antolin, Rosana ; Webb, John G. ; Sponga, Sandro ; Makkar, Raj ; Kini, Annapoorna S. ; Boukhris, Marouane ; Gervais, Philippe ; Cote, Melanie ; Holzhey, David ; Linke, Axel ; Rodes-Cabau, Josep. / Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation. I: Journal of the American College of Cardiology. 2022 ; Bind 79, Nr. 8. s. 772-785.

Bibtex

@article{b71041b7b83c4c4a96cb3b5bea31f8aa,
title = "Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation",
abstract = "BACKGROUND The optimal treatment of patients developing infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is uncertain.OBJECTIVES The goal of this study was to investigate the clinical characteristics and outcomes of patients with TAVI-IE treated with cardiac surgery and antibiotics (IE-CS) compared with patients treated with antibiotics alone (IE-AB).METHODS Crude and inverse probability of treatment weighting analyses were applied for the treatment effect of cardiac surgery vs medical therapy on 1-year all-cause mortality in patients with definite TAVI-IE. The study used data from the Infectious Endocarditis after TAVI International Registry.RESULTS Among 584 patients, 111 patients (19%) were treated with IE-CS and 473 patients (81%) with IE-AB. Compared with IE-AB, IE-CS was not associated with a lower in-hospital mortality (HRunadj: 0.85; 95% CI: 0.58-1.25) and 1-year all-cause mortality (HRunadj: 0.88; 95% CI: 0.64-1.22) in the crude cohort. After adjusting for selection and immortal time bias, IE-CS compared with IE-AB was also not associated with lower mortality rates for in-hospital mortality (HRadj: 0.92; 95% CI: 0.80-1.05) and 1-year all-cause mortality (HRadj: 0.95; 95% CI: 0.84-1.07). Results remained similar when patients with and without TAVI prosthesis involvement were analyzed separately. Predictors for in-hospital and 1-year all-cause mortality included logistic EuroSCORE I, Staphylococcus aureus, acute renal failure, persistent bacteremia, and septic shock.CONCLUSIONS In this registry, the majority of patients with TAVI-IE were treated with antibiotics alone. Cardiac surgery was not associated with an improved all-cause in-hospital or 1-year mortality. The high mortality of patients with TAVI-IE was strongly linked to patients' characteristics, pathogen, and IE-related complications. (C) 2022 by the American College of Cardiology Foundation.",
keywords = "antibiotics, cardiac surgery, infective endocarditis, outcome, TAVI, EARLY SURGERY, ASSOCIATION, MORTALITY, OUTCOMES, RISK",
author = "Norman Mangner and {del Val}, David and Mohamed Abdel-Wahab and Lisa Crusius and Eric Durand and Nikolaj Ihlemann and Marina Urena and Costanza Pellegrini and Francesco Giannini and Tomasz Gasior and Wojtek Wojakowski and Martin Landt and Vincent Auffret and Sinning, {Jan Malte} and Cheema, {Asim N.} and Luis Nombela-Franco and Chekrallah Chamandi and Francisco Campelo-Parada and Erika Munoz-Garcia and Herrmann, {Howard C.} and Luca Testa and Won-Keun Kim and Castillo, {Juan Carlos} and Alberto Alperi and Didier Tchetche and Bartorelli, {Antonio L.} and Samir Kapadia and Stefan Stortecky and Ignacio Amat-Santos and Wijeysundera, {Harindra C.} and John Lisko and Enrique Gutierrez-Ibanes and Vicenc Serra and Luisa Salido and Abdullah Alkhodair and Ugolino Livi and Tarun Chakravarty and Stamatios Lerakis and Victoria Vilalta and Ander Regueiro and Rafael Romaguera and Utz Kappert and Marco Barbanti and Jean-Bernard Masson and Frederic Maes and Claudia Fiorina and Antonio Miceli and Susheel Kodali and Ribeiro, {Henrique B.} and Mangione, {Jose Armando} and {de Brito}, {Fabio Sandoli} and Dato, {Guglielmo Mario Actis} and Francesco Rosato and Maria-Cristina Ferreira and {de Lima}, {Valter Correia} and Colafranceschi, {Alexandre Siciliano} and Alexandre Abizaid and Marino, {Marcos Antonio} and Vinicius Esteves and Julio Andrea and Godinho, {Roger R.} and Fernando Alfonso and Helene Eltchaninoff and Lars Sondergaard and Dominique Himbert and Oliver Husser and Azeem Latib and {Le Breton}, Herve and Clement Servoz and Isaac Pascual and Saif Siddiqui and Paolo Olivares and Rosana Hernandez-Antolin and Webb, {John G.} and Sandro Sponga and Raj Makkar and Kini, {Annapoorna S.} and Marouane Boukhris and Philippe Gervais and Melanie Cote and David Holzhey and Axel Linke and Josep Rodes-Cabau",
year = "2022",
doi = "10.1016/j.jacc.2021.11.056",
language = "English",
volume = "79",
pages = "772--785",
journal = "Journal of the American College of Cardiology",
issn = "0735-1097",
publisher = "Elsevier",
number = "8",

}

RIS

TY - JOUR

T1 - Surgical Treatment of Patients With Infective Endocarditis After Transcatheter Aortic Valve Implantation

AU - Mangner, Norman

AU - del Val, David

AU - Abdel-Wahab, Mohamed

AU - Crusius, Lisa

AU - Durand, Eric

AU - Ihlemann, Nikolaj

AU - Urena, Marina

AU - Pellegrini, Costanza

AU - Giannini, Francesco

AU - Gasior, Tomasz

AU - Wojakowski, Wojtek

AU - Landt, Martin

AU - Auffret, Vincent

AU - Sinning, Jan Malte

AU - Cheema, Asim N.

AU - Nombela-Franco, Luis

AU - Chamandi, Chekrallah

AU - Campelo-Parada, Francisco

AU - Munoz-Garcia, Erika

AU - Herrmann, Howard C.

AU - Testa, Luca

AU - Kim, Won-Keun

AU - Castillo, Juan Carlos

AU - Alperi, Alberto

AU - Tchetche, Didier

AU - Bartorelli, Antonio L.

AU - Kapadia, Samir

AU - Stortecky, Stefan

AU - Amat-Santos, Ignacio

AU - Wijeysundera, Harindra C.

AU - Lisko, John

AU - Gutierrez-Ibanes, Enrique

AU - Serra, Vicenc

AU - Salido, Luisa

AU - Alkhodair, Abdullah

AU - Livi, Ugolino

AU - Chakravarty, Tarun

AU - Lerakis, Stamatios

AU - Vilalta, Victoria

AU - Regueiro, Ander

AU - Romaguera, Rafael

AU - Kappert, Utz

AU - Barbanti, Marco

AU - Masson, Jean-Bernard

AU - Maes, Frederic

AU - Fiorina, Claudia

AU - Miceli, Antonio

AU - Kodali, Susheel

AU - Ribeiro, Henrique B.

AU - Mangione, Jose Armando

AU - de Brito, Fabio Sandoli

AU - Dato, Guglielmo Mario Actis

AU - Rosato, Francesco

AU - Ferreira, Maria-Cristina

AU - de Lima, Valter Correia

AU - Colafranceschi, Alexandre Siciliano

AU - Abizaid, Alexandre

AU - Marino, Marcos Antonio

AU - Esteves, Vinicius

AU - Andrea, Julio

AU - Godinho, Roger R.

AU - Alfonso, Fernando

AU - Eltchaninoff, Helene

AU - Sondergaard, Lars

AU - Himbert, Dominique

AU - Husser, Oliver

AU - Latib, Azeem

AU - Le Breton, Herve

AU - Servoz, Clement

AU - Pascual, Isaac

AU - Siddiqui, Saif

AU - Olivares, Paolo

AU - Hernandez-Antolin, Rosana

AU - Webb, John G.

AU - Sponga, Sandro

AU - Makkar, Raj

AU - Kini, Annapoorna S.

AU - Boukhris, Marouane

AU - Gervais, Philippe

AU - Cote, Melanie

AU - Holzhey, David

AU - Linke, Axel

AU - Rodes-Cabau, Josep

PY - 2022

Y1 - 2022

N2 - BACKGROUND The optimal treatment of patients developing infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is uncertain.OBJECTIVES The goal of this study was to investigate the clinical characteristics and outcomes of patients with TAVI-IE treated with cardiac surgery and antibiotics (IE-CS) compared with patients treated with antibiotics alone (IE-AB).METHODS Crude and inverse probability of treatment weighting analyses were applied for the treatment effect of cardiac surgery vs medical therapy on 1-year all-cause mortality in patients with definite TAVI-IE. The study used data from the Infectious Endocarditis after TAVI International Registry.RESULTS Among 584 patients, 111 patients (19%) were treated with IE-CS and 473 patients (81%) with IE-AB. Compared with IE-AB, IE-CS was not associated with a lower in-hospital mortality (HRunadj: 0.85; 95% CI: 0.58-1.25) and 1-year all-cause mortality (HRunadj: 0.88; 95% CI: 0.64-1.22) in the crude cohort. After adjusting for selection and immortal time bias, IE-CS compared with IE-AB was also not associated with lower mortality rates for in-hospital mortality (HRadj: 0.92; 95% CI: 0.80-1.05) and 1-year all-cause mortality (HRadj: 0.95; 95% CI: 0.84-1.07). Results remained similar when patients with and without TAVI prosthesis involvement were analyzed separately. Predictors for in-hospital and 1-year all-cause mortality included logistic EuroSCORE I, Staphylococcus aureus, acute renal failure, persistent bacteremia, and septic shock.CONCLUSIONS In this registry, the majority of patients with TAVI-IE were treated with antibiotics alone. Cardiac surgery was not associated with an improved all-cause in-hospital or 1-year mortality. The high mortality of patients with TAVI-IE was strongly linked to patients' characteristics, pathogen, and IE-related complications. (C) 2022 by the American College of Cardiology Foundation.

AB - BACKGROUND The optimal treatment of patients developing infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is uncertain.OBJECTIVES The goal of this study was to investigate the clinical characteristics and outcomes of patients with TAVI-IE treated with cardiac surgery and antibiotics (IE-CS) compared with patients treated with antibiotics alone (IE-AB).METHODS Crude and inverse probability of treatment weighting analyses were applied for the treatment effect of cardiac surgery vs medical therapy on 1-year all-cause mortality in patients with definite TAVI-IE. The study used data from the Infectious Endocarditis after TAVI International Registry.RESULTS Among 584 patients, 111 patients (19%) were treated with IE-CS and 473 patients (81%) with IE-AB. Compared with IE-AB, IE-CS was not associated with a lower in-hospital mortality (HRunadj: 0.85; 95% CI: 0.58-1.25) and 1-year all-cause mortality (HRunadj: 0.88; 95% CI: 0.64-1.22) in the crude cohort. After adjusting for selection and immortal time bias, IE-CS compared with IE-AB was also not associated with lower mortality rates for in-hospital mortality (HRadj: 0.92; 95% CI: 0.80-1.05) and 1-year all-cause mortality (HRadj: 0.95; 95% CI: 0.84-1.07). Results remained similar when patients with and without TAVI prosthesis involvement were analyzed separately. Predictors for in-hospital and 1-year all-cause mortality included logistic EuroSCORE I, Staphylococcus aureus, acute renal failure, persistent bacteremia, and septic shock.CONCLUSIONS In this registry, the majority of patients with TAVI-IE were treated with antibiotics alone. Cardiac surgery was not associated with an improved all-cause in-hospital or 1-year mortality. The high mortality of patients with TAVI-IE was strongly linked to patients' characteristics, pathogen, and IE-related complications. (C) 2022 by the American College of Cardiology Foundation.

KW - antibiotics

KW - cardiac surgery

KW - infective endocarditis

KW - outcome

KW - TAVI

KW - EARLY SURGERY

KW - ASSOCIATION

KW - MORTALITY

KW - OUTCOMES

KW - RISK

U2 - 10.1016/j.jacc.2021.11.056

DO - 10.1016/j.jacc.2021.11.056

M3 - Journal article

C2 - 35210032

VL - 79

SP - 772

EP - 785

JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

SN - 0735-1097

IS - 8

ER -

ID: 314148591