Suppression of tumor growth in vivo by local and systemic 90K level increase.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Suppression of tumor growth in vivo by local and systemic 90K level increase. / Jallal, B; Powell, J; Zachwieja, J; Brakebusch, C; Germain, L; Jacobs, J; Iacobelli, S; Ullrich, A.
I: Cancer Research, Bind 55, Nr. 15, 1995, s. 3223-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Suppression of tumor growth in vivo by local and systemic 90K level increase.
AU - Jallal, B
AU - Powell, J
AU - Zachwieja, J
AU - Brakebusch, C
AU - Germain, L
AU - Jacobs, J
AU - Iacobelli, S
AU - Ullrich, A
N1 - Keywords: Animals; Antigens, Neoplasm; Carrier Proteins; Cell Adhesion Molecules; Cell Division; Glioblastoma; Glycoproteins; Humans; Immunity, Cellular; Intercellular Adhesion Molecule-1; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lipoproteins; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Proteins; Tumor Cells, Cultured; Tumor Markers, Biological; Vascular Cell Adhesion Molecule-1
PY - 1995
Y1 - 1995
N2 - Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (> 80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.
AB - Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (> 80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.
M3 - Journal article
C2 - 7542166
VL - 55
SP - 3223
EP - 3227
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 15
ER -
ID: 5160345