Suppression of tumor growth in vivo by local and systemic 90K level increase.

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Standard

Suppression of tumor growth in vivo by local and systemic 90K level increase. / Jallal, B; Powell, J; Zachwieja, J; Brakebusch, C; Germain, L; Jacobs, J; Iacobelli, S; Ullrich, A.

I: Cancer Research, Bind 55, Nr. 15, 1995, s. 3223-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jallal, B, Powell, J, Zachwieja, J, Brakebusch, C, Germain, L, Jacobs, J, Iacobelli, S & Ullrich, A 1995, 'Suppression of tumor growth in vivo by local and systemic 90K level increase.', Cancer Research, bind 55, nr. 15, s. 3223-7.

APA

Jallal, B., Powell, J., Zachwieja, J., Brakebusch, C., Germain, L., Jacobs, J., Iacobelli, S., & Ullrich, A. (1995). Suppression of tumor growth in vivo by local and systemic 90K level increase. Cancer Research, 55(15), 3223-7.

Vancouver

Jallal B, Powell J, Zachwieja J, Brakebusch C, Germain L, Jacobs J o.a. Suppression of tumor growth in vivo by local and systemic 90K level increase. Cancer Research. 1995;55(15):3223-7.

Author

Jallal, B ; Powell, J ; Zachwieja, J ; Brakebusch, C ; Germain, L ; Jacobs, J ; Iacobelli, S ; Ullrich, A. / Suppression of tumor growth in vivo by local and systemic 90K level increase. I: Cancer Research. 1995 ; Bind 55, Nr. 15. s. 3223-7.

Bibtex

@article{d6686bd0595611dd8d9f000ea68e967b,
title = "Suppression of tumor growth in vivo by local and systemic 90K level increase.",
abstract = "Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (> 80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.",
author = "B Jallal and J Powell and J Zachwieja and C Brakebusch and L Germain and J Jacobs and S Iacobelli and A Ullrich",
note = "Keywords: Animals; Antigens, Neoplasm; Carrier Proteins; Cell Adhesion Molecules; Cell Division; Glioblastoma; Glycoproteins; Humans; Immunity, Cellular; Intercellular Adhesion Molecule-1; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lipoproteins; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Proteins; Tumor Cells, Cultured; Tumor Markers, Biological; Vascular Cell Adhesion Molecule-1",
year = "1995",
language = "English",
volume = "55",
pages = "3223--7",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research",
number = "15",

}

RIS

TY - JOUR

T1 - Suppression of tumor growth in vivo by local and systemic 90K level increase.

AU - Jallal, B

AU - Powell, J

AU - Zachwieja, J

AU - Brakebusch, C

AU - Germain, L

AU - Jacobs, J

AU - Iacobelli, S

AU - Ullrich, A

N1 - Keywords: Animals; Antigens, Neoplasm; Carrier Proteins; Cell Adhesion Molecules; Cell Division; Glioblastoma; Glycoproteins; Humans; Immunity, Cellular; Intercellular Adhesion Molecule-1; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lipoproteins; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Proteins; Tumor Cells, Cultured; Tumor Markers, Biological; Vascular Cell Adhesion Molecule-1

PY - 1995

Y1 - 1995

N2 - Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (> 80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.

AB - Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (> 80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.

M3 - Journal article

C2 - 7542166

VL - 55

SP - 3223

EP - 3227

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 15

ER -

ID: 5160345