Successful nonsibling bone marrow transplantation in severe combined immunodeficiency
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Successful nonsibling bone marrow transplantation in severe combined immunodeficiency. / Ramsøe, K; Skinhøj, P; Andersen, V; Ernst, P; Faber, V; Platz, P; Thomsen, M; Svejgaard, A; Eriksen, K R; Plesner, T; Morling, N; Philip, J; Killmann, S A; Koch, C; Muller-Bérat, N; Henningsen, K; Axelsen, H.
I: Transplantation, Bind 26, Nr. 6, 1978, s. 369-72.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Successful nonsibling bone marrow transplantation in severe combined immunodeficiency
AU - Ramsøe, K
AU - Skinhøj, P
AU - Andersen, V
AU - Ernst, P
AU - Faber, V
AU - Platz, P
AU - Thomsen, M
AU - Svejgaard, A
AU - Eriksen, K R
AU - Plesner, T
AU - Morling, N
AU - Philip, J
AU - Killmann, S A
AU - Koch, C
AU - Muller-Bérat, N
AU - Henningsen, K
AU - Axelsen, H
N1 - Keywords: Bone Marrow Transplantation; Female; HLA Antigens; Humans; Immunologic Deficiency Syndromes; Infant; Male; Pedigree; Transplantation, Homologous
PY - 1978
Y1 - 1978
N2 - Severe combined immunodeficiency (SCID) was diagnosed in a girl immediately after birth; her older brother had SCID and was successfully reconstituted by bone marrow transplantation from his uncle. She was isolated in a laminar air flow bench and decontaminated. The father differed by one HLA-A antigen but was HLA-Dw2 homozygous like the patient; his lymphocytes showed a slight response to the patient's cells in mixed lymphocyte culture (MLC). At the age of 2 1/2 months and again at 5 months, she was given a bone marrow transplant from the father. During the entire course the patient had no infections, and apart from a transient eosinophilia she had no signs of graft-versus-host reaction. Immunological reconstitution was nearly complete at 9 months of age, when she was recontaminated. One year later plasma immunoglobulin concentrations are in the low normal range (IgG and IgM) or decreased (IgA); tests of cell-mediated immunity are normal. Apart from slight upper respiratory infections, the patient has been healthy. Physical and psychological development have been normal.
AB - Severe combined immunodeficiency (SCID) was diagnosed in a girl immediately after birth; her older brother had SCID and was successfully reconstituted by bone marrow transplantation from his uncle. She was isolated in a laminar air flow bench and decontaminated. The father differed by one HLA-A antigen but was HLA-Dw2 homozygous like the patient; his lymphocytes showed a slight response to the patient's cells in mixed lymphocyte culture (MLC). At the age of 2 1/2 months and again at 5 months, she was given a bone marrow transplant from the father. During the entire course the patient had no infections, and apart from a transient eosinophilia she had no signs of graft-versus-host reaction. Immunological reconstitution was nearly complete at 9 months of age, when she was recontaminated. One year later plasma immunoglobulin concentrations are in the low normal range (IgG and IgM) or decreased (IgA); tests of cell-mediated immunity are normal. Apart from slight upper respiratory infections, the patient has been healthy. Physical and psychological development have been normal.
M3 - Journal article
C2 - 366819
VL - 26
SP - 369
EP - 372
JO - Transplantation
JF - Transplantation
SN - 0041-1337
IS - 6
ER -
ID: 18693735