Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes. / Burgdorf, Kristoffer Sølvsten; Sandholt, Camilla Helene; Sparsø, Thomas; Andersen, Gitte; Witte, Daniel R; Jørgensen, Torben; Sandbaek, Anelli; Lauritzen, Torsten; Sørensen, Thorkild I A; Madsbad, Sten; Hansen, Torben; Pedersen, Oluf.
I: European Journal of Endocrinology, Bind 163, Nr. 1, 01.07.2010, s. 81-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Studies of association between LPIN1 variants and common metabolic phenotypes among 17,538 Danes
AU - Burgdorf, Kristoffer Sølvsten
AU - Sandholt, Camilla Helene
AU - Sparsø, Thomas
AU - Andersen, Gitte
AU - Witte, Daniel R
AU - Jørgensen, Torben
AU - Sandbaek, Anelli
AU - Lauritzen, Torsten
AU - Sørensen, Thorkild I A
AU - Madsbad, Sten
AU - Hansen, Torben
AU - Pedersen, Oluf
PY - 2010/7/1
Y1 - 2010/7/1
N2 - Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.
AB - Lipin-1, encoded by LPIN1, is expressed in the major metabolically active tissues. Decreased expression of lipin-1 in adipose tissue correlates with increased insulin resistance, and tagging of the LPIN1 locus has shown that rs33997857, rs6744682, and rs6708316 associate with metabolic phenotypes, specifically body mass index (BMI) and fasting serum lipid levels, both on the individual single-nucleotide polymorphism level and with a three-marker haplotype. Our aim was to validate the reported findings in the Danish population.
KW - Adult
KW - Body Mass Index
KW - Case-Control Studies
KW - Denmark
KW - Diabetes Mellitus, Type 2
KW - European Continental Ancestry Group
KW - Female
KW - Genetic Predisposition to Disease
KW - Genetic Variation
KW - Genotype
KW - Haplotypes
KW - Humans
KW - Male
KW - Middle Aged
KW - Nuclear Proteins
KW - Obesity
KW - Waist Circumference
U2 - 10.1530/EJE-10-0068
DO - 10.1530/EJE-10-0068
M3 - Journal article
C2 - 20356931
VL - 163
SP - 81
EP - 87
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 1
ER -
ID: 33502175