Structural and Functional Brain Changes in Migraine
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Structural and Functional Brain Changes in Migraine. / Ashina, Sait; Bentivegna, Enrico; Martelletti, Paolo; Eikermann-Haerter, Katharina.
I: Pain and Therapy, Bind 10, 2021, s. 211-223.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Structural and Functional Brain Changes in Migraine
AU - Ashina, Sait
AU - Bentivegna, Enrico
AU - Martelletti, Paolo
AU - Eikermann-Haerter, Katharina
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2021
Y1 - 2021
N2 - Migraine is a prevalent primary headache disorder and is usually considered as benign. However, structural and functional changes in the brain of individuals with migraine have been reported. High frequency of white matter abnormalities, silent infarct-like lesions, and volumetric changes in both gray and white matter in individuals with migraine compared to controls have been demonstrated. Functional magnetic resonance imaging (MRI) studies found altered connectivity in both the interictal and ictal phase of migraine. MR spectroscopy and positron emission tomography studies suggest abnormal energy metabolism and mitochondrial dysfunction, as well as other metabolic changes in individuals with migraine. In this review, we provide a brief overview of neuroimaging studies that have helped us to characterize some of these changes and discuss their limitations, including small sample sizes and poorly defined control groups. A better understanding of alterations in the brains of patients with migraine could help not only in the diagnosis but may potentially lead to the optimization of a targeted anti-migraine therapy.
AB - Migraine is a prevalent primary headache disorder and is usually considered as benign. However, structural and functional changes in the brain of individuals with migraine have been reported. High frequency of white matter abnormalities, silent infarct-like lesions, and volumetric changes in both gray and white matter in individuals with migraine compared to controls have been demonstrated. Functional magnetic resonance imaging (MRI) studies found altered connectivity in both the interictal and ictal phase of migraine. MR spectroscopy and positron emission tomography studies suggest abnormal energy metabolism and mitochondrial dysfunction, as well as other metabolic changes in individuals with migraine. In this review, we provide a brief overview of neuroimaging studies that have helped us to characterize some of these changes and discuss their limitations, including small sample sizes and poorly defined control groups. A better understanding of alterations in the brains of patients with migraine could help not only in the diagnosis but may potentially lead to the optimization of a targeted anti-migraine therapy.
KW - Brain
KW - Functional
KW - Migraine
KW - MRI
KW - Neuroimaging
KW - PET
KW - Spectroscopy
KW - Structural
U2 - 10.1007/s40122-021-00240-5
DO - 10.1007/s40122-021-00240-5
M3 - Review
C2 - 33594593
AN - SCOPUS:85108666305
VL - 10
SP - 211
EP - 223
JO - Pain and Therapy
JF - Pain and Therapy
SN - 2193-8237
ER -
ID: 279820631