TY - JOUR

T1 - STRengthening analytical thinking for observational studies

T2 - The STRATOS initiative

AU - Sauerbrei, Willi

AU - Abrahamowicz, Michal

AU - Altman, Douglas G.

AU - le Cessie, Saskia

AU - Carpenter, James

AU - Abrahamowicz, Michal

AU - Andersen, Per Kragh

AU - Altman, Doug

AU - Becher, Heiko

AU - Binder, Harald

AU - Blettner, Maria

AU - Bodicoat, Danielle

AU - Bossuyt, Patrick

AU - Carpenter, James

AU - Carroll, Raymond

AU - Chadha-Boreham, Harbajan

AU - Collins, Gary

AU - De Stavola, Bianca

AU - Duchateau, Luc

AU - Evans, Stephen

AU - Freedman, Laurence

AU - Gail, Mitchell

AU - Goetghebeur, Els

AU - Gustafson, Paul

AU - Harrell, Frank

AU - Huebner, Marianne

AU - Jenkner, Carolin

AU - Kipnis, Victor

AU - Kuechenhoff, Helmut

AU - Cessie, Saskia le

AU - Lee, Kate

AU - Macaskill, Petra

AU - Moodie, Erica

AU - Pearce, Neil

AU - Quantin, Catherine

AU - Rahnenfuehrer, Joerg

AU - Royston, Patrick

AU - Sauerbrei, Willi

AU - Schumacher, Martin

AU - Sekula, Peggy

AU - Stefanski, Len

AU - Steyerberg, Ewout

AU - Therneau, Terry

AU - Tilling, Kate

AU - Vach, Werner

AU - Vickers, Andrew

AU - Wacholder, Sholom

AU - Waernbaum, Ingeborg

AU - White, Ian

AU - Woodward, Mark

PY - 2014/12/30

Y1 - 2014/12/30

N2 - The validity and practical utility of observational medical research depends critically on good study design, excellent data quality, appropriate statistical methods and accurate interpretation of results. Statistical methodology has seen substantial development in recent times. Unfortunately, many of these methodological developments are ignored in practice. Consequently, design and analysis of observational studies often exhibit serious weaknesses. The lack of guidance on vital practical issues discourages many applied researchers from using more sophisticated and possibly more appropriate methods when analyzing observational studies. Furthermore, many analyses are conducted by researchers with a relatively weak statistical background and limited experience in using statistical methodology and software. Consequently, even 'standard' analyses reported in the medical literature are often flawed, casting doubt on their results and conclusions. An efficient way to help researchers to keep up with recent methodological developments is to develop guidance documents that are spread to the research community at large. These observations led to the initiation of the strengthening analytical thinking for observational studies (STRATOS) initiative, a large collaboration of experts in many different areas of biostatistical research. The objective of STRATOS is to provide accessible and accurate guidance in the design and analysis of observational studies. The guidance is intended for applied statisticians and other data analysts with varying levels of statistical education, experience and interests.In this article, we introduce the STRATOS initiative and its main aims, present the need for guidance documents and outline the planned approach and progress so far. We encourage other biostatisticians to become involved.

AB - The validity and practical utility of observational medical research depends critically on good study design, excellent data quality, appropriate statistical methods and accurate interpretation of results. Statistical methodology has seen substantial development in recent times. Unfortunately, many of these methodological developments are ignored in practice. Consequently, design and analysis of observational studies often exhibit serious weaknesses. The lack of guidance on vital practical issues discourages many applied researchers from using more sophisticated and possibly more appropriate methods when analyzing observational studies. Furthermore, many analyses are conducted by researchers with a relatively weak statistical background and limited experience in using statistical methodology and software. Consequently, even 'standard' analyses reported in the medical literature are often flawed, casting doubt on their results and conclusions. An efficient way to help researchers to keep up with recent methodological developments is to develop guidance documents that are spread to the research community at large. These observations led to the initiation of the strengthening analytical thinking for observational studies (STRATOS) initiative, a large collaboration of experts in many different areas of biostatistical research. The objective of STRATOS is to provide accessible and accurate guidance in the design and analysis of observational studies. The guidance is intended for applied statisticians and other data analysts with varying levels of statistical education, experience and interests.In this article, we introduce the STRATOS initiative and its main aims, present the need for guidance documents and outline the planned approach and progress so far. We encourage other biostatisticians to become involved.

KW - Guidance for analysis

KW - Level of statistical knowledge

KW - Observational studies

U2 - 10.1002/sim.6265

DO - 10.1002/sim.6265

M3 - Journal article

C2 - 25074480

AN - SCOPUS:84918821784

VL - 33

SP - 5413

EP - 5432

JO - Statistics in Medicine

JF - Statistics in Medicine

SN - 0277-6715

IS - 30

ER -