Strategies for developing phages into novel antimicrobial tailocins
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Strategies for developing phages into novel antimicrobial tailocins. / Woudstra, Cedric; Sørensen, Anders Nørgaard; Sørensen, Martine C.Holst; Brøndsted, Lone.
I: Trends in Microbiology, 2024.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Strategies for developing phages into novel antimicrobial tailocins
AU - Woudstra, Cedric
AU - Sørensen, Anders Nørgaard
AU - Sørensen, Martine C.Holst
AU - Brøndsted, Lone
N1 - Publisher Copyright: © 2024 The Author(s)
PY - 2024
Y1 - 2024
N2 - Tailocins are high-molecular-weight bacteriocins produced by bacteria to kill related environmental competitors by binding and puncturing their target. Tailocins are promising alternative antimicrobials, yet the diversity of naturally occurring tailocins is limited. The structural similarities between phage tails and tailocins advocate using phages as scaffolds for developing new tailocins. This article reviews three strategies for producing tailocins: disrupting the capsid–tail junction of phage particles, blocking capsid assembly during phage propagation, and creating headless phage particles synthetically. Particularly appealing is the production of tailocins through synthetic biology using phages with contractile tails as scaffolds to unlock the antimicrobial potential of tailocins.
AB - Tailocins are high-molecular-weight bacteriocins produced by bacteria to kill related environmental competitors by binding and puncturing their target. Tailocins are promising alternative antimicrobials, yet the diversity of naturally occurring tailocins is limited. The structural similarities between phage tails and tailocins advocate using phages as scaffolds for developing new tailocins. This article reviews three strategies for producing tailocins: disrupting the capsid–tail junction of phage particles, blocking capsid assembly during phage propagation, and creating headless phage particles synthetically. Particularly appealing is the production of tailocins through synthetic biology using phages with contractile tails as scaffolds to unlock the antimicrobial potential of tailocins.
KW - antimicrobial
KW - bacteriophage
KW - genetic engineering
KW - headless phage
KW - phage tail-like particle
KW - tailocin
U2 - 10.1016/j.tim.2024.03.003
DO - 10.1016/j.tim.2024.03.003
M3 - Review
C2 - 38580606
AN - SCOPUS:85189466484
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
ER -
ID: 390191204