Strategies for developing phages into novel antimicrobial tailocins

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Strategies for developing phages into novel antimicrobial tailocins. / Woudstra, Cedric; Sørensen, Anders Nørgaard; Sørensen, Martine C.Holst; Brøndsted, Lone.

I: Trends in Microbiology, 2024.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Woudstra, C, Sørensen, AN, Sørensen, MCH & Brøndsted, L 2024, 'Strategies for developing phages into novel antimicrobial tailocins', Trends in Microbiology. https://doi.org/10.1016/j.tim.2024.03.003

APA

Woudstra, C., Sørensen, A. N., Sørensen, M. C. H., & Brøndsted, L. (2024). Strategies for developing phages into novel antimicrobial tailocins. Trends in Microbiology. https://doi.org/10.1016/j.tim.2024.03.003

Vancouver

Woudstra C, Sørensen AN, Sørensen MCH, Brøndsted L. Strategies for developing phages into novel antimicrobial tailocins. Trends in Microbiology. 2024. https://doi.org/10.1016/j.tim.2024.03.003

Author

Woudstra, Cedric ; Sørensen, Anders Nørgaard ; Sørensen, Martine C.Holst ; Brøndsted, Lone. / Strategies for developing phages into novel antimicrobial tailocins. I: Trends in Microbiology. 2024.

Bibtex

@article{d19b21820a604fdd9b2bb9cf7b567f91,

title = "Strategies for developing phages into novel antimicrobial tailocins",

abstract = "Tailocins are high-molecular-weight bacteriocins produced by bacteria to kill related environmental competitors by binding and puncturing their target. Tailocins are promising alternative antimicrobials, yet the diversity of naturally occurring tailocins is limited. The structural similarities between phage tails and tailocins advocate using phages as scaffolds for developing new tailocins. This article reviews three strategies for producing tailocins: disrupting the capsid–tail junction of phage particles, blocking capsid assembly during phage propagation, and creating headless phage particles synthetically. Particularly appealing is the production of tailocins through synthetic biology using phages with contractile tails as scaffolds to unlock the antimicrobial potential of tailocins.",

keywords = "antimicrobial, bacteriophage, genetic engineering, headless phage, phage tail-like particle, tailocin",

author = "Cedric Woudstra and S{\o}rensen, {Anders N{\o}rgaard} and S{\o}rensen, {Martine C.Holst} and Lone Br{\o}ndsted",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

doi = "10.1016/j.tim.2024.03.003",

language = "English",

journal = "Trends in Microbiology",

issn = "0966-842X",

publisher = "Elsevier Ltd. * Trends Journals",

}

RIS

TY - JOUR

T1 - Strategies for developing phages into novel antimicrobial tailocins

AU - Woudstra, Cedric

AU - Sørensen, Anders Nørgaard

AU - Sørensen, Martine C.Holst

AU - Brøndsted, Lone

PY - 2024

Y1 - 2024

N2 - Tailocins are high-molecular-weight bacteriocins produced by bacteria to kill related environmental competitors by binding and puncturing their target. Tailocins are promising alternative antimicrobials, yet the diversity of naturally occurring tailocins is limited. The structural similarities between phage tails and tailocins advocate using phages as scaffolds for developing new tailocins. This article reviews three strategies for producing tailocins: disrupting the capsid–tail junction of phage particles, blocking capsid assembly during phage propagation, and creating headless phage particles synthetically. Particularly appealing is the production of tailocins through synthetic biology using phages with contractile tails as scaffolds to unlock the antimicrobial potential of tailocins.

AB - Tailocins are high-molecular-weight bacteriocins produced by bacteria to kill related environmental competitors by binding and puncturing their target. Tailocins are promising alternative antimicrobials, yet the diversity of naturally occurring tailocins is limited. The structural similarities between phage tails and tailocins advocate using phages as scaffolds for developing new tailocins. This article reviews three strategies for producing tailocins: disrupting the capsid–tail junction of phage particles, blocking capsid assembly during phage propagation, and creating headless phage particles synthetically. Particularly appealing is the production of tailocins through synthetic biology using phages with contractile tails as scaffolds to unlock the antimicrobial potential of tailocins.

KW - antimicrobial

KW - bacteriophage

KW - genetic engineering

KW - headless phage

KW - phage tail-like particle

KW - tailocin

U2 - 10.1016/j.tim.2024.03.003

DO - 10.1016/j.tim.2024.03.003

M3 - Review

C2 - 38580606

AN - SCOPUS:85189466484

JO - Trends in Microbiology

JF - Trends in Microbiology

SN - 0966-842X

ER -

ID: 390191204