Stimulation in primary MLR caused by a PLT defined non-HLA-D/DR determinant, EP1
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Stimulation in primary MLR caused by a PLT defined non-HLA-D/DR determinant, EP1. / Holter, W; Morling, N.
I: HLA, Bind 22, Nr. 1, 1983, s. 42-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Stimulation in primary MLR caused by a PLT defined non-HLA-D/DR determinant, EP1
AU - Holter, W
AU - Morling, N
N1 - Keywords: Epitopes; HLA-DR Antigens; Histocompatibility Antigens Class II; Humans; Isoantigens; Lymphocyte Activation; Lymphocyte Culture Test, Mixed
PY - 1983
Y1 - 1983
N2 - The influence in primary mixed lymphocyte culture reaction (MLR) of a primed lymphocyte typing (PLT) defined non-HLA-D/DR determinant, EP1, was investigated. In primary MLR between HLA-D/DR compatible lymphocytes, the response of the lymphocytes from 14 EP1-negative HLA-D/DR heterozygous individuals towards two EP1-positive homozygous typing cells (HTCs) was on an average approximately 35% higher than the response towards two EP1-negative HTCs (P less than 0.01). The strength of the MLR between lymphocytes from 25 EP1-negative and 10 EP1-positive individuals matched for two HLA-D/DR antigens was investigated. The average responses of EP1-negative lymphocytes against EP1-positive lymphocytes were approximately 40% higher than the average responses against EP1-negative lymphocytes (P less than 0.01). These data indicate that the PLT defined determinant EP1 causes stimulation in primary MLR.
AB - The influence in primary mixed lymphocyte culture reaction (MLR) of a primed lymphocyte typing (PLT) defined non-HLA-D/DR determinant, EP1, was investigated. In primary MLR between HLA-D/DR compatible lymphocytes, the response of the lymphocytes from 14 EP1-negative HLA-D/DR heterozygous individuals towards two EP1-positive homozygous typing cells (HTCs) was on an average approximately 35% higher than the response towards two EP1-negative HTCs (P less than 0.01). The strength of the MLR between lymphocytes from 25 EP1-negative and 10 EP1-positive individuals matched for two HLA-D/DR antigens was investigated. The average responses of EP1-negative lymphocytes against EP1-positive lymphocytes were approximately 40% higher than the average responses against EP1-negative lymphocytes (P less than 0.01). These data indicate that the PLT defined determinant EP1 causes stimulation in primary MLR.
M3 - Journal article
C2 - 6193606
VL - 22
SP - 42
EP - 48
JO - HLA
JF - HLA
SN - 2059-2302
IS - 1
ER -
ID: 18693170