Spinal Cord Stimulation–Naïve Patients vs Patients With Failed Previous Experiences With Standard Spinal Cord Stimulation: Two Distinct Entities or One Population?
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Spinal Cord Stimulation–Naïve Patients vs Patients With Failed Previous Experiences With Standard Spinal Cord Stimulation : Two Distinct Entities or One Population? / Goudman, Lisa; Rigoard, Philippe; Billot, Maxime; De Smedt, Ann; Roulaud, Manuel; Consortium, Discover; Moens, Maarten; Eykens, Tom; De Keersmaecker, Kelly; Gorissen, Mayken; De Clerck, Christ; Donck, Ann Ver; Braems, Hannie; Buyse, Klaas; Puylaert, Martine; Duyvendak, Wim; De Smet, Chris; Vissers, Steven; Debeuf, Johan; De Beucker, Kim; Ceuppens, Jeroen; Germonpré, Pieter Jan; Mortier, Sarah; Van Buyten, Jean Pierre; Smet, Iris; Devos, Marieke; Vanhauwaert, Dimitri; Billet, Bart; Hanssens, Karel; Demeyere, Annemarie; Casier, Tine; Bertrem, Bénédicte; Van Havenbergh, Tony; Van Looy, Pieter; Heylen, Gertje; de Schryver, Catherine; Vangeneugden, Johan; Louis, Frédéric; Stalmans, Virginie; Remacle, Jean Michel; Remacle, Thibault; Mauviel, Stéphane; Abeloos, Laurence; Theys, Tom; Van Hoylandt, Anaïs; Bruyninckx, Dominike; Das, John; Callebaut, Ina; Lorgeoux, Bertille; Van Hooff, Robbert Jan; Discover Consortium.
I: Neuromodulation, Bind 26, Nr. 1, 2023, s. 157-163.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Spinal Cord Stimulation–Naïve Patients vs Patients With Failed Previous Experiences With Standard Spinal Cord Stimulation
T2 - Two Distinct Entities or One Population?
AU - Goudman, Lisa
AU - Rigoard, Philippe
AU - Billot, Maxime
AU - De Smedt, Ann
AU - Roulaud, Manuel
AU - Consortium, Discover
AU - Moens, Maarten
AU - Eykens, Tom
AU - De Keersmaecker, Kelly
AU - Gorissen, Mayken
AU - De Clerck, Christ
AU - Donck, Ann Ver
AU - Braems, Hannie
AU - Buyse, Klaas
AU - Puylaert, Martine
AU - Duyvendak, Wim
AU - De Smet, Chris
AU - Vissers, Steven
AU - Debeuf, Johan
AU - De Beucker, Kim
AU - Ceuppens, Jeroen
AU - Germonpré, Pieter Jan
AU - Mortier, Sarah
AU - Van Buyten, Jean Pierre
AU - Smet, Iris
AU - Devos, Marieke
AU - Vanhauwaert, Dimitri
AU - Billet, Bart
AU - Hanssens, Karel
AU - Demeyere, Annemarie
AU - Casier, Tine
AU - Bertrem, Bénédicte
AU - Van Havenbergh, Tony
AU - Van Looy, Pieter
AU - Heylen, Gertje
AU - de Schryver, Catherine
AU - Vangeneugden, Johan
AU - Louis, Frédéric
AU - Stalmans, Virginie
AU - Remacle, Jean Michel
AU - Remacle, Thibault
AU - Mauviel, Stéphane
AU - Abeloos, Laurence
AU - Theys, Tom
AU - Van Hoylandt, Anaïs
AU - Bruyninckx, Dominike
AU - Das, John
AU - Callebaut, Ina
AU - Lorgeoux, Bertille
AU - Van Hooff, Robbert Jan
AU - Discover Consortium
N1 - Publisher Copyright: © 2022 International Neuromodulation Society
PY - 2023
Y1 - 2023
N2 - Introduction: Nowadays, the success of spinal cord stimulation (SCS) is evaluated separately in patients who have previous experiences with standard SCS and in SCS-naïve patients. Nevertheless, it is yet to be evaluated whether both patient groups are effectively distinct patient groups. Therefore, the aims of this study are twofold: 1) Are there clusters in the data to distinguish between both patient groups? 2) Can we discriminate both patient groups based on routinely collected clinical parameters? Materials and Methods: Baseline data from the Discover study were used, in which 263 patients with persistent spinal pain syndrome type 2 were included (185 neurostimulation-naïve patients and 78 patients with previous SCS experience). Pain intensity scores for low back and leg pain, functional disability, medication use, and health-related quality of life utility scores were used in the analysis. Model-based clustering was performed on standardized data. Discriminant analysis was performed with linear and quadratic discriminant analysis, with leave-one-out cross-validation to evaluate model performance. Results: Model-based clustering revealed two different clusters in the data. None of the clusters clearly separated SCS-naïve patients from patients with previous SCS experience. Linear discriminant analysis resulted in a leave-one-out cross-validation error rate of 30.0% to discriminate between both patient groups, based on routinely collected clinical parameters. Conclusions: Clustering analysis did not result in clusters that separate SCS-naïve patients from patients with previous SCS experience. This may suggest that both patient groups should not be considered as two different patient groups when comparing them on routine clinical parameters, with potentially profound implications for research and clinical settings. Clinical Trial Registration: The Clinicaltrials.gov registration number for the Discover study is NCT02787265.
AB - Introduction: Nowadays, the success of spinal cord stimulation (SCS) is evaluated separately in patients who have previous experiences with standard SCS and in SCS-naïve patients. Nevertheless, it is yet to be evaluated whether both patient groups are effectively distinct patient groups. Therefore, the aims of this study are twofold: 1) Are there clusters in the data to distinguish between both patient groups? 2) Can we discriminate both patient groups based on routinely collected clinical parameters? Materials and Methods: Baseline data from the Discover study were used, in which 263 patients with persistent spinal pain syndrome type 2 were included (185 neurostimulation-naïve patients and 78 patients with previous SCS experience). Pain intensity scores for low back and leg pain, functional disability, medication use, and health-related quality of life utility scores were used in the analysis. Model-based clustering was performed on standardized data. Discriminant analysis was performed with linear and quadratic discriminant analysis, with leave-one-out cross-validation to evaluate model performance. Results: Model-based clustering revealed two different clusters in the data. None of the clusters clearly separated SCS-naïve patients from patients with previous SCS experience. Linear discriminant analysis resulted in a leave-one-out cross-validation error rate of 30.0% to discriminate between both patient groups, based on routinely collected clinical parameters. Conclusions: Clustering analysis did not result in clusters that separate SCS-naïve patients from patients with previous SCS experience. This may suggest that both patient groups should not be considered as two different patient groups when comparing them on routine clinical parameters, with potentially profound implications for research and clinical settings. Clinical Trial Registration: The Clinicaltrials.gov registration number for the Discover study is NCT02787265.
KW - Clustering
KW - discriminant analysis
KW - failed back surgery syndrome
KW - machine learning
KW - persistent spinal pain syndrome type 2
U2 - 10.1016/j.neurom.2022.04.037
DO - 10.1016/j.neurom.2022.04.037
M3 - Journal article
C2 - 35551868
AN - SCOPUS:85132668897
VL - 26
SP - 157
EP - 163
JO - Neuromodulation: Technology at the Neural Interface
JF - Neuromodulation: Technology at the Neural Interface
SN - 1094-7159
IS - 1
ER -
ID: 323970449