Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans

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Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans. / Jorgensen, Anders; Brandslund, Ivan; Ellervik, Christina; Henriksen, Trine; Weimann, Allan; Andersen, Per Kragh; Poulsen, Henrik E.

I: Aging Cell, Bind 22, Nr. 6, e13839, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jorgensen, A, Brandslund, I, Ellervik, C, Henriksen, T, Weimann, A, Andersen, PK & Poulsen, HE 2023, 'Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans', Aging Cell, bind 22, nr. 6, e13839. https://doi.org/10.1111/acel.13839

APA

Jorgensen, A., Brandslund, I., Ellervik, C., Henriksen, T., Weimann, A., Andersen, P. K., & Poulsen, H. E. (2023). Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans. Aging Cell, 22(6), [e13839]. https://doi.org/10.1111/acel.13839

Vancouver

Jorgensen A, Brandslund I, Ellervik C, Henriksen T, Weimann A, Andersen PK o.a. Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans. Aging Cell. 2023;22(6). e13839. https://doi.org/10.1111/acel.13839

Author

Jorgensen, Anders ; Brandslund, Ivan ; Ellervik, Christina ; Henriksen, Trine ; Weimann, Allan ; Andersen, Per Kragh ; Poulsen, Henrik E. / Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans. I: Aging Cell. 2023 ; Bind 22, Nr. 6.

Bibtex

@article{b51c9191c89d4fc7a20ca9592afe82a1,

title = "Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans",

abstract = "Modifications of nucleic acids (DNA and RNA) from oxidative stress is a potential driver of aging per se and of mortality in age-associated medical disorders such as type 2 diabetes (T2D). In a human cohort, we found a strong prediction of all-cause mortality by a marker of systemic oxidation of RNA in patients with T2D (n = 2672) and in nondiabetic control subjects (n = 4079). The finding persisted after the adjustment of established modifiers of oxidative stress (including BMI, smoking, and glycated hemoglobin). In contrast, systemic levels of DNA damage from oxidation, which traditionally has been causally linked to both T2D and aging, failed to predict mortality. Strikingly, these findings were subsequently replicated in an independent general population study (n = 3649). The data demonstrate a specific importance of RNA damage from oxidation in T2D and general aging.",

keywords = "aging, mortality, nucleic acids, oxidative stress",

author = "Anders Jorgensen and Ivan Brandslund and Christina Ellervik and Trine Henriksen and Allan Weimann and Andersen, {Per Kragh} and Poulsen, {Henrik E.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.",

year = "2023",

doi = "10.1111/acel.13839",

language = "English",

volume = "22",

journal = "Aging Cell",

issn = "1474-9718",

publisher = "Wiley-Blackwell",

number = "6",

}

RIS

TY - JOUR

T1 - Specific prediction of mortality by oxidative stress-induced damage to RNA vs. DNA in humans

AU - Jorgensen, Anders

AU - Brandslund, Ivan

AU - Ellervik, Christina

AU - Henriksen, Trine

AU - Weimann, Allan

AU - Andersen, Per Kragh

AU - Poulsen, Henrik E.

PY - 2023

Y1 - 2023

N2 - Modifications of nucleic acids (DNA and RNA) from oxidative stress is a potential driver of aging per se and of mortality in age-associated medical disorders such as type 2 diabetes (T2D). In a human cohort, we found a strong prediction of all-cause mortality by a marker of systemic oxidation of RNA in patients with T2D (n = 2672) and in nondiabetic control subjects (n = 4079). The finding persisted after the adjustment of established modifiers of oxidative stress (including BMI, smoking, and glycated hemoglobin). In contrast, systemic levels of DNA damage from oxidation, which traditionally has been causally linked to both T2D and aging, failed to predict mortality. Strikingly, these findings were subsequently replicated in an independent general population study (n = 3649). The data demonstrate a specific importance of RNA damage from oxidation in T2D and general aging.

AB - Modifications of nucleic acids (DNA and RNA) from oxidative stress is a potential driver of aging per se and of mortality in age-associated medical disorders such as type 2 diabetes (T2D). In a human cohort, we found a strong prediction of all-cause mortality by a marker of systemic oxidation of RNA in patients with T2D (n = 2672) and in nondiabetic control subjects (n = 4079). The finding persisted after the adjustment of established modifiers of oxidative stress (including BMI, smoking, and glycated hemoglobin). In contrast, systemic levels of DNA damage from oxidation, which traditionally has been causally linked to both T2D and aging, failed to predict mortality. Strikingly, these findings were subsequently replicated in an independent general population study (n = 3649). The data demonstrate a specific importance of RNA damage from oxidation in T2D and general aging.

KW - aging

KW - mortality

KW - nucleic acids

KW - oxidative stress

U2 - 10.1111/acel.13839

DO - 10.1111/acel.13839

M3 - Journal article

C2 - 37190886

AN - SCOPUS:85159310914

VL - 22

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 6

M1 - e13839

ER -

ID: 347579970