Specialized astrocytes mediate glutamatergic gliotransmission in the CNS
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Originalsprog | Engelsk |
---|---|
Tidsskrift | Nature |
Vol/bind | 622 |
Sider (fra-til) | 120-129 |
Antal sider | 10 |
ISSN | 0028-0836 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
We thank H. Stubbe for technical support with animal breeding and genotyping through a large part of the project; D. Sahlender for initial characterization of GFAPSlc17a6tdTomato mice; C. Vivar Rios for developing the pipeline for glutamate imaging analysis in situ in the first part of the study; C. Ruiz and F. Calvo from the CSR-UNIL team for developing an open source version of the same imaging pipeline; J. Prados for sharing the torch prediction algorithm and for his general advice; E. Magrinelli for performing initial bioinformatic analysis of patch-seq experiments and integration of the existing databases; B. Xiong for contributing to image acquisition for the RNAscope HiPlex experiment; R. Edwards and F. Kirchhoff for sharing the Slc17a6 and GLASTP2ry1 mouse lines, respectively; M. Holt, M. Batiuk and A. Martirosyan for sharing unpublished data and methods, advice and discussions; C. Pryce for advice on protocols and analysis of behavioural experiments; N. Liaudet for advice on imaging experiments and analysis, and for reading parts of the manuscript; and D. Jabaudon for advice on single-cell transcriptomics and for reading the manuscript. Research in the Volterra laboratory was supported by Swiss National Science Foundation (SNSF) NCCR TransCure grant/award number 51NF40-160620; SNSF grants/award numbers 31003A-173124 and 31003B-201276; European Research Council (ERC) Advanced Grant 340368 “Astromnesis”; Stiftung Synapsis—Demenz Forschung Schweiz DFS, grant/award number 2018-PI-01; and the Wyss Center for Bio and Neuroengineering, Geneva. Research in the Telley laboratory was supported by ERC starting grant CERDEV_759112 and a SNSF grant 31003A_182676/1. creERT2 fl/fl lsl/lsl fl/fl creERT2 fl/fl
Publisher Copyright:
© 2023, The Author(s).
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