Solid-state interactions between trimethoprim and parabens
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Solid-state interactions between trimethoprim and the esters of 4-hydroxybenzoic acid (parahydroxybenzoates or parabens) used for anti-microbial preservation are investigated. The formation of a crystalline 1/1 molecular compound between trimethoprim and methyl parahydroxybenzoate is demonstrated by differential scanning calorimetry, X-ray powder diffraction, Fourier transform infrared spectroscopy, and solid-state C-13-NMR. Interactions between trimethoprim and 4-hydroxybenzoic acid and its ethyl,propyl and butyl esters were not observed. The nature of the trimethoprim and methyl parahydroxybenzoate intermolecular bonding is discussed briefly.
Originalsprog | Udefineret/Ukendt |
---|---|
Tidsskrift | STP pharma sciences |
Vol/bind | 4 |
Udgave nummer | 4 |
Sider (fra-til) | 292-297 |
Antal sider | 6 |
Status | Udgivet - 1994 |
- interactions trimethoprim parabens differential scanning calorimetry c-13-nmr fourier transform infrared spectroscopy 1-1 molecular-compound
Forskningsområder
ID: 38062149