Solid-phase synthesis of complex and pharmacologically interesting heterocycles
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Solid-phase synthesis of complex and pharmacologically interesting heterocycles. / Nielsen, Thomas E.; Meldal, Morten.
I: Current Opinion in Drug Discovery and Development, Bind 12, Nr. 6, 11.2009, s. 798-810.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Solid-phase synthesis of complex and pharmacologically interesting heterocycles
AU - Nielsen, Thomas E.
AU - Meldal, Morten
PY - 2009/11
Y1 - 2009/11
N2 - Efficient routes for the creation of heterocycles continue to be one of the primary goals for solid-phase synthesis. Recent advances in this field rely most notably on transition-metal-catalysis and N-acyliminium chemistry to mediate a range of cyclization processes for the generation of compounds with significant structural complexity and diversity. This review describes some of the most systematic solid-phase approaches that are potentially suited for pharmaceutical applications, that is, the methods described are useful for the synthesis of compound collections, and exhibit tunable stereochemistry, scaffold structure, and appendage modification.
AB - Efficient routes for the creation of heterocycles continue to be one of the primary goals for solid-phase synthesis. Recent advances in this field rely most notably on transition-metal-catalysis and N-acyliminium chemistry to mediate a range of cyclization processes for the generation of compounds with significant structural complexity and diversity. This review describes some of the most systematic solid-phase approaches that are potentially suited for pharmaceutical applications, that is, the methods described are useful for the synthesis of compound collections, and exhibit tunable stereochemistry, scaffold structure, and appendage modification.
KW - Combinatorial chemistry
KW - Heterocycle
KW - N-acyliminium chemistry
KW - Pictet-Spengler reaction
KW - Solid-phase synthesis
UR - http://www.scopus.com/inward/record.url?scp=70350749437&partnerID=8YFLogxK
M3 - Review
C2 - 19894191
AN - SCOPUS:70350749437
VL - 12
SP - 798
EP - 810
JO - Current Opinion in Drug Discovery and Development
JF - Current Opinion in Drug Discovery and Development
SN - 1367-6733
IS - 6
ER -
ID: 321825105