Sniffing out significant "pee values": Genome wide association study of asparagus anosmia
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Sniffing out significant "pee values" : Genome wide association study of asparagus anosmia. / Markt, Sarah C.; Nuttall, Elizabeth; Turman, Constance; Sinnott, Jennifer; Rimm, Eric B.; Ecsedy, Ethan; Unger, Robert H.; Fall, Katja; Finn, Stephen; Jensen, Majken K.; Rider, Jennifer R.; Kraft, Peter; Mucci, Lorelei A.
I: BMJ (Online), Bind 355, i6071, 2016.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Sniffing out significant "pee values"
T2 - Genome wide association study of asparagus anosmia
AU - Markt, Sarah C.
AU - Nuttall, Elizabeth
AU - Turman, Constance
AU - Sinnott, Jennifer
AU - Rimm, Eric B.
AU - Ecsedy, Ethan
AU - Unger, Robert H.
AU - Fall, Katja
AU - Finn, Stephen
AU - Jensen, Majken K.
AU - Rider, Jennifer R.
AU - Kraft, Peter
AU - Mucci, Lorelei A.
PY - 2016
Y1 - 2016
N2 - Objective To determine the inherited factors associated with the ability to smell asparagus metabolites in urine. Design Genome wide association study. Setting Nurses' Health Study and Health Professionals Follow-up Study cohorts. Participants 6909 men and women of European-American descent with available genetic data from genome wide association studies. Main outcom e measure Participants were characterised as asparagus smellers if they strongly agreed with the prompt "after eating asparagus, you notice a strong characteristic odor in your urine," and anosmic if otherwise. We calculated per-allele estimates of asparagus anosmia for about nine million single nucleotide polymorphisms using logistic regression. P values <5×10-8 were considered as genome wide significant. Results 58.0% of men (n=1449/2500) and 61.5% of women (n=2712/4409) had anosmia. 871 single nucleotide polymorphisms reached genome wide significance for asparagus anosmia, all in a region on chromosome 1 (1q44: 248139851-248595299) containing multiple genes in the olfactory receptor 2 (OR2) family. Conditional analyses revealed three independent markers associated with asparagus anosmia: rs13373863, rs71538191, and rs6689553. Conclusion A large proportion of people have asparagus anosmia. Genetic variation near multiple olfactory receptor genes is associated with the ability of an individual to smell the metabolites of asparagus in urine. Future replication studies are necessary before considering targeted therapies to help anosmic people discover what they are missing.
AB - Objective To determine the inherited factors associated with the ability to smell asparagus metabolites in urine. Design Genome wide association study. Setting Nurses' Health Study and Health Professionals Follow-up Study cohorts. Participants 6909 men and women of European-American descent with available genetic data from genome wide association studies. Main outcom e measure Participants were characterised as asparagus smellers if they strongly agreed with the prompt "after eating asparagus, you notice a strong characteristic odor in your urine," and anosmic if otherwise. We calculated per-allele estimates of asparagus anosmia for about nine million single nucleotide polymorphisms using logistic regression. P values <5×10-8 were considered as genome wide significant. Results 58.0% of men (n=1449/2500) and 61.5% of women (n=2712/4409) had anosmia. 871 single nucleotide polymorphisms reached genome wide significance for asparagus anosmia, all in a region on chromosome 1 (1q44: 248139851-248595299) containing multiple genes in the olfactory receptor 2 (OR2) family. Conditional analyses revealed three independent markers associated with asparagus anosmia: rs13373863, rs71538191, and rs6689553. Conclusion A large proportion of people have asparagus anosmia. Genetic variation near multiple olfactory receptor genes is associated with the ability of an individual to smell the metabolites of asparagus in urine. Future replication studies are necessary before considering targeted therapies to help anosmic people discover what they are missing.
U2 - 10.1136/bmj.i6071
DO - 10.1136/bmj.i6071
M3 - Journal article
C2 - 27965198
AN - SCOPUS:85006341240
VL - 355
JO - The BMJ
JF - The BMJ
SN - 0959-8146
M1 - i6071
ER -
ID: 339684506