TY - JOUR

T1 - Shift work and incidence of dementia

T2 - A Danish Nurse Cohort study

AU - Jørgensen, Jeanette Therming

AU - Hansen, Johnni

AU - Westendorp, Rudi G.J.

AU - Nabe-Nielsen, Kirsten

AU - Stayner, Leslie Thomas

AU - Simonsen, Mette Kildevæld

AU - Andersen, Zorana Jovanovic

PY - 2020

Y1 - 2020

N2 - Introduction: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. Methods: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. Results: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06). Discussion: Persistent night shift work may increase the risk of dementia.

AB - Introduction: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. Methods: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. Results: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06). Discussion: Persistent night shift work may increase the risk of dementia.

KW - Alzheimer's disease and dementia

KW - cohort study

KW - Danish Nurse Cohort

KW - Denmark

KW - neurodegenerative disease

KW - night shift work

KW - shift work

KW - working time

U2 - 10.1002/alz.12126

DO - 10.1002/alz.12126

M3 - Journal article

C2 - 32652788

AN - SCOPUS:85087713262

VL - 16

SP - 1268

EP - 1279

JO - Alzheimer's & Dementia

JF - Alzheimer's & Dementia

SN - 1552-5260

IS - 9

ER -