Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

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Standard

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. / Haney, Jillian R.; CommonMind Consortium; PsychENCODE Consortium; iPSYCH-BROAD Working Group.

I: Science, Bind 359, Nr. 6376, 09.02.2018, s. 693-697.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Haney, JR, CommonMind Consortium, PsychENCODE Consortium & iPSYCH-BROAD Working Group 2018, 'Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap', Science, bind 359, nr. 6376, s. 693-697. https://doi.org/10.1126/science.aad6469

APA

Haney, J. R., CommonMind Consortium, PsychENCODE Consortium, & iPSYCH-BROAD Working Group (2018). Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science, 359(6376), 693-697. https://doi.org/10.1126/science.aad6469

Vancouver

Haney JR, CommonMind Consortium, PsychENCODE Consortium, iPSYCH-BROAD Working Group. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science. 2018 feb. 9;359(6376):693-697. https://doi.org/10.1126/science.aad6469

Author

Haney, Jillian R. ; CommonMind Consortium ; PsychENCODE Consortium ; iPSYCH-BROAD Working Group. / Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. I: Science. 2018 ; Bind 359, Nr. 6376. s. 693-697.

Bibtex

@article{de7652c868074f3e9cc4ebe5e7aaa2eb,
title = "Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap",
abstract = "The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders—autism, schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched controls. We identified patterns of shared and distinct gene-expression perturbations across these conditions. The degree of sharing of transcriptional dysregulation is related to polygenic (single-nucleotide polymorphism–based) overlap across disorders, suggesting a substantial causal genetic component. This comprehensive systems-level view of the neurobiological architecture of major neuropsychiatric illness demonstrates pathways of molecular convergence and specificity.",
author = "Gandal, {Michael J.} and Haney, {Jillian R.} and Werge, {Thomas M.} and {CommonMind Consortium} and {PsychENCODE Consortium} and {iPSYCH-BROAD Working Group}",
year = "2018",
month = feb,
day = "9",
doi = "10.1126/science.aad6469",
language = "English",
volume = "359",
pages = "693--697",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6376",

}

RIS

TY - JOUR

T1 - Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

AU - Gandal, Michael J.

AU - Haney, Jillian R.

AU - Werge, Thomas M.

AU - CommonMind Consortium

AU - PsychENCODE Consortium

AU - iPSYCH-BROAD Working Group

PY - 2018/2/9

Y1 - 2018/2/9

N2 - The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders—autism, schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched controls. We identified patterns of shared and distinct gene-expression perturbations across these conditions. The degree of sharing of transcriptional dysregulation is related to polygenic (single-nucleotide polymorphism–based) overlap across disorders, suggesting a substantial causal genetic component. This comprehensive systems-level view of the neurobiological architecture of major neuropsychiatric illness demonstrates pathways of molecular convergence and specificity.

AB - The predisposition to neuropsychiatric disease involves a complex, polygenic, and pleiotropic genetic architecture. However, little is known about how genetic variants impart brain dysfunction or pathology. We used transcriptomic profiling as a quantitative readout of molecular brain-based phenotypes across five major psychiatric disorders—autism, schizophrenia, bipolar disorder, depression, and alcoholism—compared with matched controls. We identified patterns of shared and distinct gene-expression perturbations across these conditions. The degree of sharing of transcriptional dysregulation is related to polygenic (single-nucleotide polymorphism–based) overlap across disorders, suggesting a substantial causal genetic component. This comprehensive systems-level view of the neurobiological architecture of major neuropsychiatric illness demonstrates pathways of molecular convergence and specificity.

UR - http://www.scopus.com/inward/record.url?scp=85041925301&partnerID=8YFLogxK

U2 - 10.1126/science.aad6469

DO - 10.1126/science.aad6469

M3 - Journal article

C2 - 29439242

AN - SCOPUS:85041925301

VL - 359

SP - 693

EP - 697

JO - Science

JF - Science

SN - 0036-8075

IS - 6376

ER -

ID: 199177196