Severe Congenital Heart Defects and Cerebral Palsy
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To report the prevalence of cerebral palsy (CP) in children with severe congenital heart defects (sCHD) and the outcome/severity of the CP.
Methods
Population-based, data linkage study between CP and congenital anomaly registers in Europe and Australia. The EUROCAT definition of severe CHD (sCHD) was used. Linked data from 4 regions in Europe and 2 in Australia were included. All children born in the regions from 1991 through 2009 diagnosed with CP and/or sCHD were included. Linkage was completed locally. Deidentified linked data were pooled for analyses.
Results
The study sample included 4989 children with CP and 3684 children with sCHD. The total number of livebirths in the population was 1 734 612. The prevalence of CP was 2.9 per 1000 births (95% CI, 2.8-3.0) and the prevalence of sCHD was 2.1 per 1000 births (95% CI, 2.1-2.2). Of children with sCHD, 1.5% (n = 57) had a diagnosis of CP, of which 35 (61%) children had prenatally or perinatally acquired CP (resulting from a brain injury at ≤28 days of life) and 22 (39%) children had a postneonatal cause (a brain injury between 28 days and 2 years). Children with CP and sCHD more often had unilateral spastic CP and more intellectual impairments than children with CP without congenital anomalies.
Conclusions
In high-income countries, the proportion of children with CP is much higher in children with sCHD than in the background population. The severity of disease in children with CP and sCHD is milder compared with children with CP without congenital anomalies.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 113617 |
| Tidsskrift | Journal of Pediatrics |
| Vol/bind | 262 |
| Antal sider | 8 |
| ISSN | 0022-3476 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
Finally, we acknowledge the support of EUROCAT, Surveillance of Cerebral Palsy Europe, and the Australian Cerebral Palsy Register.
Funding Information:
We thank the children and families whose data are included in the participating registers, which enables this epidemiological research. We gratefully acknowledge the participating registers and their staff, who assisted with the extraction, linkage, and cleaning of data contributed to the overarching Comprehensive CA-CP study, and with queries regarding the data: The Danish Cerebral Palsy Register (Peter Uldall, Bjarne Laursen); EUROCAT Malformation Registry for Funen, Denmark; Norwegian Quality and Surveillance Registry for Cerebral Palsy (Guro L. Andersen); Medical Birth Registry of Norway; Programa de Vigilância Nacional da Paralisia Cerebral aos 5 Anos, Portugal (Ana Cadete, Daniel Virella, Joaquim Avarelhão, Teresa Folha); Registo Nacional de Anomalias Congénitas, Portugal (Ausenda Machado, Carlos Matias Dias); Register of Cerebral Palsy of Croatia (Katarina Vulin); Zagreb EUROCAT Register (Ljubica Boban); South Australian Register of Birth Defects and Cerebral Palsy (Heather Scott); Western Australian Register for Developmental Anomalies (Gareth Baynam). We also acknowledge registers that participated in the overarching Comprehensive CA-CP Study: RHEOP, Grenoble, France; REMERA, France; CP Register of Western Sweden; Swedish Register of Birth Defects; the Victorian Congenital Anomalies Register, Department of Health and Human Services (Victoria), Center for Victorian Data Linkage, and the Victorian Cerebral Palsy Register. We also thank Dr James Densem, BioMedical Computing Ltd. This study has used data from the Medical Birth Registry of Norway. The interpretation and reporting of these data is the sole responsibility of the authors, and no endorsement by the Medical Birth Registry of Norway is intended nor should be inferred. Finally, we acknowledge the support of EUROCAT, Surveillance of Cerebral Palsy Europe, and the Australian Cerebral Palsy Register. SG had full access to all the data and took responsibility for its integrity and the data analysis.
Publisher Copyright:
© 2023 The Authors
ID: 375191825