Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus
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Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus. / Andersen, T.; Munthe-Fog, L.; Garred, P.; Jacobsen, Søren; Andersen, Trine; Munthe-Fog, Lea; Garred, Peter; Jacobsen, Søren.
I: Journal of Rheumatology, Bind 36, Nr. 4, 01.04.2009, s. 757-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus
AU - Andersen, T.
AU - Munthe-Fog, L.
AU - Garred, P.
AU - Jacobsen, Søren
AU - Andersen, Trine
AU - Munthe-Fog, Lea
AU - Garred, Peter
AU - Jacobsen, Søren
N1 - Keywords: Adolescent; Adult; Aged; Child; Female; Glycoproteins; Humans; Lectins; Lupus Erythematosus, Systemic; Male; Middle Aged; Severity of Illness Index; Young Adult
PY - 2009/4/1
Y1 - 2009/4/1
N2 - OBJECTIVE: Ficolin-3 is a serum protein of putative importance in autoimmunity. Our objective was to investigate any differential expression of ficolin-3 in patients with systemic lupus erythematosus (SLE) or its clinical subsets. METHODS: Serum levels of ficolin-3 (S-ficolin-3) were determined in 95 patients with SLE and 103 healthy controls using an ELISA. RESULTS: Median S-ficolin-3 was 56.1 microg/ml (range 0 to >or=87.3) and 32.4 microg/ml (10 to >or=87.3) in patients and controls, respectively (p<0.001). Increased S-ficolin-3 was associated with hemolysis, positive Coombs test, and lymphopenia, but not with SLE Disease Activity Index scores or C-reactive protein. In one patient without detectable S-ficolin-3, the FCN3 gene appeared normal. CONCLUSION: The elevation of S-ficolin-3 and its association with specific manifestations in SLE may indicate a pathogenetic role of ficolin-3 in SLE.
AB - OBJECTIVE: Ficolin-3 is a serum protein of putative importance in autoimmunity. Our objective was to investigate any differential expression of ficolin-3 in patients with systemic lupus erythematosus (SLE) or its clinical subsets. METHODS: Serum levels of ficolin-3 (S-ficolin-3) were determined in 95 patients with SLE and 103 healthy controls using an ELISA. RESULTS: Median S-ficolin-3 was 56.1 microg/ml (range 0 to >or=87.3) and 32.4 microg/ml (10 to >or=87.3) in patients and controls, respectively (p<0.001). Increased S-ficolin-3 was associated with hemolysis, positive Coombs test, and lymphopenia, but not with SLE Disease Activity Index scores or C-reactive protein. In one patient without detectable S-ficolin-3, the FCN3 gene appeared normal. CONCLUSION: The elevation of S-ficolin-3 and its association with specific manifestations in SLE may indicate a pathogenetic role of ficolin-3 in SLE.
U2 - 10.3899/jrheum.080361
DO - 10.3899/jrheum.080361
M3 - Journal article
C2 - 19208603
VL - 36
SP - 757
EP - 759
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 4
ER -
ID: 19440313