Serum concentrations of GM-CSF and G-CSF correlate with the Th1/Th2 cytokine response in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
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Serum concentrations of GM-CSF and G-CSF correlate with the Th1/Th2 cytokine response in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection. / Moser, Claus; Jensen, Peter Østrup; Pressler, Tacjana; Frederiksen, Birgitte; Lanng, Susanne; Kharazmi, Arsalan; Koch, Christian; Høiby, Niels.
I: APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, Bind 113, Nr. 6, 06.2005, s. 400-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Serum concentrations of GM-CSF and G-CSF correlate with the Th1/Th2 cytokine response in cystic fibrosis patients with chronic Pseudomonas aeruginosa lung infection
AU - Moser, Claus
AU - Jensen, Peter Østrup
AU - Pressler, Tacjana
AU - Frederiksen, Birgitte
AU - Lanng, Susanne
AU - Kharazmi, Arsalan
AU - Koch, Christian
AU - Høiby, Niels
PY - 2005/6
Y1 - 2005/6
N2 - The inflammation in cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa lung infection is dominated by polymorphonuclear neutrophils (PMNs). There seems to be a relationship between the PMN-dominated inflammation, pronounced antibody production and a Th2-dominated response. Apart from mobilizing monocytes and PMNs from the bone marrow, GM-CSF, G-CSF and IL-3 select subsets of dendritic cells, which subsequently induce distinct Th responses. Therefore, the present study examines the correlation between the mobilizing cytokines in serum and the Th responses. The IFN-gamma and IL-4 production by peripheral blood mononuclear cells, and the concentrations of GM-CSF and G-CSF in serum as well as lung function, were determined in 37 CF patients with and 6 CF patients without chronic P. aeruginosa lung infection. The GM-CSF/G-CSF ratio correlated both with the IFN-gamma production and good lung function. In addition, an inverse correlation between IL-3 and IFN-gamma was observed. The results indicate involvement of endogenous GM-CSF, G-CSF and IL-3 in the skewed Th response in CF, and change to a Th1-dominated response might be achieved with GM-CSF treatment.
AB - The inflammation in cystic fibrosis (CF) patients with chronic Pseudomonas aeruginosa lung infection is dominated by polymorphonuclear neutrophils (PMNs). There seems to be a relationship between the PMN-dominated inflammation, pronounced antibody production and a Th2-dominated response. Apart from mobilizing monocytes and PMNs from the bone marrow, GM-CSF, G-CSF and IL-3 select subsets of dendritic cells, which subsequently induce distinct Th responses. Therefore, the present study examines the correlation between the mobilizing cytokines in serum and the Th responses. The IFN-gamma and IL-4 production by peripheral blood mononuclear cells, and the concentrations of GM-CSF and G-CSF in serum as well as lung function, were determined in 37 CF patients with and 6 CF patients without chronic P. aeruginosa lung infection. The GM-CSF/G-CSF ratio correlated both with the IFN-gamma production and good lung function. In addition, an inverse correlation between IL-3 and IFN-gamma was observed. The results indicate involvement of endogenous GM-CSF, G-CSF and IL-3 in the skewed Th response in CF, and change to a Th1-dominated response might be achieved with GM-CSF treatment.
KW - Adolescent
KW - Adult
KW - Chronic Disease
KW - Cystic Fibrosis
KW - Cytokines
KW - Female
KW - Granulocyte Colony-Stimulating Factor
KW - Granulocyte-Macrophage Colony-Stimulating Factor
KW - Humans
KW - Male
KW - Pneumonia, Bacterial
KW - Prognosis
KW - Pseudomonas Infections
KW - Pseudomonas aeruginosa
KW - Th1 Cells
KW - Th2 Cells
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1111/j.1600-0463.2005.apm_142.x
DO - 10.1111/j.1600-0463.2005.apm_142.x
M3 - Journal article
C2 - 15996157
VL - 113
SP - 400
EP - 409
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 6
ER -
ID: 181873498