Serum concentrations of free and total insulin-like growth factor-I, IGF binding proteins -1 and -3 and IGFBP-3 protease activity in boys with normal or precocious puberty
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Circulating IGF-I and IGF binding protein-3 (IGFBP-3) levels both increase in puberty where growth velocity is high. The amount of free IGF-I is dependent on the IGF-I level and on the concentrations of the specific IGFBPs. Furthermore, IGFBP-3 proteolysis regulates the bioavailability of IGF-I. However, the concentration of free IGF-I and possible IGFBP-3 proteolytic activity in puberty has not previously been studied.
Originalsprog | Engelsk |
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Tidsskrift | Clinical Endocrinology |
Vol/bind | 44 |
Udgave nummer | 5 |
Sider (fra-til) | 515-23 |
Antal sider | 9 |
ISSN | 0300-0664 |
Status | Udgivet - 1996 |
ID: 48486539