Serological identification of neoantigens on mouse fibroblasts which have undergone "spontaneous" malignant alteration in vitro.
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Serological identification of neoantigens on mouse fibroblasts which have undergone "spontaneous" malignant alteration in vitro. / Willumsen, B M; Ulrich, K; Kieler, J.
I: International Journal of Cancer, Bind 23, Nr. 2, 1979, s. 209-16.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Serological identification of neoantigens on mouse fibroblasts which have undergone "spontaneous" malignant alteration in vitro.
AU - Willumsen, B M
AU - Ulrich, K
AU - Kieler, J
N1 - Keywords: Animals; Cell Line; Cell Transformation, Neoplastic; Cross Reactions; Epitopes; Fibroblasts; Fluorescent Antibody Technique; Immune Sera; Mice; Precipitation; Radioimmunoassay; Retroviridae; Viral Proteins
PY - 1979
Y1 - 1979
N2 - ST-L1 is a cell line established from lung explants from a normal ST/a mouse. The ST-L1 cells have undergone spontaneous malignant alteration in vitro. The cells were rejected after inoculation into syngeneic immunocompetent hosts, and a syngeneic humoral immuneresponse against the ST-L1 cells has been detected. The specificity of this humoral response was investigated. The syngeneic response to ST-L1 was characterized by indirect immunofluorescence tests and by immunoprecipitation of radiolabelled cells and of a C-type virus produced by the cell lines. The specific anti-ST-L1 reactivities were found to be directed against the envelope glycoprotein of an endogenous C-type virus expressed by the antigenic cell line.
AB - ST-L1 is a cell line established from lung explants from a normal ST/a mouse. The ST-L1 cells have undergone spontaneous malignant alteration in vitro. The cells were rejected after inoculation into syngeneic immunocompetent hosts, and a syngeneic humoral immuneresponse against the ST-L1 cells has been detected. The specificity of this humoral response was investigated. The syngeneic response to ST-L1 was characterized by indirect immunofluorescence tests and by immunoprecipitation of radiolabelled cells and of a C-type virus produced by the cell lines. The specific anti-ST-L1 reactivities were found to be directed against the envelope glycoprotein of an endogenous C-type virus expressed by the antigenic cell line.
M3 - Journal article
C2 - 83967
VL - 23
SP - 209
EP - 216
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -
ID: 2890715