Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair
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Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair. / Xia, Jingjing; Swiercz, Jakub M.; Bañón-Rodríguez, Inmaculada; Matković, Ivana; Federico, Giuseppina; Sun, Tianliang; Franz, Timo; Brakebusch, Cord Herbert; Kumanogoh, Atsushi; Friedel, Roland H.; Martín-Belmonte, Fernando; Gröne, Hermann-Josef; Offermanns, Stefan; Worzfeld, Thomas.
I: Developmental Cell, Bind 33, Nr. 3, 05.2015, s. 299-313.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair
AU - Xia, Jingjing
AU - Swiercz, Jakub M.
AU - Bañón-Rodríguez, Inmaculada
AU - Matković, Ivana
AU - Federico, Giuseppina
AU - Sun, Tianliang
AU - Franz, Timo
AU - Brakebusch, Cord Herbert
AU - Kumanogoh, Atsushi
AU - Friedel, Roland H.
AU - Martín-Belmonte, Fernando
AU - Gröne, Hermann-Josef
AU - Offermanns, Stefan
AU - Worzfeld, Thomas
N1 - Copyright © 2015 Elsevier Inc. All rights reserved.
PY - 2015/5
Y1 - 2015/5
N2 - Morphogenesis, homeostasis, and regeneration of epithelial tissues rely on the accurate orientation of cell divisions, which is specified by the mitotic spindle axis. To remain in the epithelial plane, symmetrically dividing epithelial cells align their mitotic spindle axis with the plane. Here, we show that this alignment depends on epithelial cell-cell communication via semaphorin-plexin signaling. During kidney morphogenesis and repair, renal tubular epithelial cells lacking the transmembrane receptor Plexin-B2 or its semaphorin ligands fail to correctly orient the mitotic spindle, leading to severe defects in epithelial architecture and function. Analyses of a series of transgenic and knockout mice indicate that Plexin-B2 controls the cell division axis by signaling through its GTPase-activating protein (GAP) domain and Cdc42. Our data uncover semaphorin-plexin signaling as a central regulatory mechanism of mitotic spindle orientation necessary for the alignment of epithelial cell divisions with the epithelial plane.
AB - Morphogenesis, homeostasis, and regeneration of epithelial tissues rely on the accurate orientation of cell divisions, which is specified by the mitotic spindle axis. To remain in the epithelial plane, symmetrically dividing epithelial cells align their mitotic spindle axis with the plane. Here, we show that this alignment depends on epithelial cell-cell communication via semaphorin-plexin signaling. During kidney morphogenesis and repair, renal tubular epithelial cells lacking the transmembrane receptor Plexin-B2 or its semaphorin ligands fail to correctly orient the mitotic spindle, leading to severe defects in epithelial architecture and function. Analyses of a series of transgenic and knockout mice indicate that Plexin-B2 controls the cell division axis by signaling through its GTPase-activating protein (GAP) domain and Cdc42. Our data uncover semaphorin-plexin signaling as a central regulatory mechanism of mitotic spindle orientation necessary for the alignment of epithelial cell divisions with the epithelial plane.
U2 - 10.1016/j.devcel.2015.02.001
DO - 10.1016/j.devcel.2015.02.001
M3 - Journal article
C2 - 25892012
VL - 33
SP - 299
EP - 313
JO - Developmental Cell
JF - Developmental Cell
SN - 1534-5807
IS - 3
ER -
ID: 136713591