Self-inflicted DNA breaks in cell differentiation and cancer
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Self-inflicted DNA breaks in cell differentiation and cancer. / Benada, Jan; Alsowaida, Dalal; Megeney, Lynn A.; Sørensen, Claus S.
I: Trends in Cell Biology, Bind 33, Nr. 10, 2023, s. 850-859.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Self-inflicted DNA breaks in cell differentiation and cancer
AU - Benada, Jan
AU - Alsowaida, Dalal
AU - Megeney, Lynn A.
AU - Sørensen, Claus S.
PY - 2023
Y1 - 2023
N2 - Self-inflicted DNA strand breaks are canonically linked with cell death pathways and the establishment of genetic diversity in immune and germline cells. Moreover, this form of DNA damage is an established source of genome instability in cancer development. However, recent studies indicate that nonlethal self-inflicted DNA strand breaks play an indispensable but underappreciated role in a variety of cell processes, including differentiation and cancer therapy responses. Mechanistically, these physiological DNA breaks originate from the activation of nucleases, which are best characterized for inducing DNA fragmentation in apoptotic cell death. In this review, we outline the emerging biology of one critical nuclease, caspase-activated DNase (CAD), and how directed activation or deployment of this enzyme can lead to divergent cell fate outcomes.
AB - Self-inflicted DNA strand breaks are canonically linked with cell death pathways and the establishment of genetic diversity in immune and germline cells. Moreover, this form of DNA damage is an established source of genome instability in cancer development. However, recent studies indicate that nonlethal self-inflicted DNA strand breaks play an indispensable but underappreciated role in a variety of cell processes, including differentiation and cancer therapy responses. Mechanistically, these physiological DNA breaks originate from the activation of nucleases, which are best characterized for inducing DNA fragmentation in apoptotic cell death. In this review, we outline the emerging biology of one critical nuclease, caspase-activated DNase (CAD), and how directed activation or deployment of this enzyme can lead to divergent cell fate outcomes.
U2 - 10.1016/j.tcb.2023.03.002
DO - 10.1016/j.tcb.2023.03.002
M3 - Journal article
C2 - 36997393
VL - 33
SP - 850
EP - 859
JO - Trends in Cell Biology
JF - Trends in Cell Biology
SN - 0962-8924
IS - 10
ER -
ID: 340710165