Self-assessed health status and associated mortality in endocarditis: secondary findings from the POET trial
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Self-assessed health status and associated mortality in endocarditis : secondary findings from the POET trial. / Bundgaard, Johan S.; Iversen, Kasper; Pries-Heje, Mia; Ihlemann, Nikolaj; Gill, Sabine U.; Madsen, Trine; Elming, Hanne; Povlsen, Jonas A.; Bruun, Niels E.; Høfsten, Dan E.; Fuursted, Kurt; Christensen, Jens J.; Schultz, Martin; Rosenvinge, Flemming; Helweg‑Larsen, Jannik; Køber, Lars; Torp‑Pedersen, Christian; Fosbøl, Emil L.; Tønder, Niels; Moser, Claus; Bundgaard, Henning; Mogensen, Ulrik M.
I: Quality of Life Research, Bind 31, 2022, s. 2655–2662.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Self-assessed health status and associated mortality in endocarditis
T2 - secondary findings from the POET trial
AU - Bundgaard, Johan S.
AU - Iversen, Kasper
AU - Pries-Heje, Mia
AU - Ihlemann, Nikolaj
AU - Gill, Sabine U.
AU - Madsen, Trine
AU - Elming, Hanne
AU - Povlsen, Jonas A.
AU - Bruun, Niels E.
AU - Høfsten, Dan E.
AU - Fuursted, Kurt
AU - Christensen, Jens J.
AU - Schultz, Martin
AU - Rosenvinge, Flemming
AU - Helweg‑Larsen, Jannik
AU - Køber, Lars
AU - Torp‑Pedersen, Christian
AU - Fosbøl, Emil L.
AU - Tønder, Niels
AU - Moser, Claus
AU - Bundgaard, Henning
AU - Mogensen, Ulrik M.
N1 - Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022
Y1 - 2022
N2 - Purpose: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis. Methods: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model. Results: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4–34.8) and 5.4 (95% CI 4.1–7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7–7.0, p < 0.01). Conclusion: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257. Trial registry: POET ClinicalTrials.gov number, NCT01375257.
AB - Purpose: Self-assessed poor health status is associated with increased risk of mortality in several cardiovascular conditions, but has not been investigated in patients with endocarditis. We examined health status and mortality in patients with endocarditis. Methods: This is a re-specified substudy of the randomized POET endocarditis trial, which included 400 patients. Patients completed the single-question self-assessed health status from the Short-Form 36 questionnaire at time of randomization and were categorized as having poor or non-poor (excellent/very good, good, or fair) health status. Self-assessed health status and all-cause mortality were examined by a Cox regression model. Results: Self-assessed health status was completed by 266 (67%) patients with a mean age of 68.0 years (± 11.8), 54 (20%) were females, and 86 (32%) had one or more major concurrent medical conditions besides endocarditis. The self-assessed health status distribution was poor (n = 21, 8%) and non-poor (n = 245, 92%). The median follow-up was 3.3 years and death occurred in 9 (43%) and 48 (20%) patients reporting poor and non-poor health status, respectively, and mortality rates [mortality/100 person-years, 95% confidence interval (CI)] were 18.1 (95% CI 9.4–34.8) and 5.4 (95% CI 4.1–7.2), i.e., the crude hazard ratio for death was 3.4 (95% CI: 1.7–7.0, p < 0.01). Conclusion: Self-assessed poor health status compared with non-poor health status as assessed by a single question was associated with a threefold increased long-term mortality in patients with endocarditis. POET ClinicalTrials.gov number, NCT01375257. Trial registry: POET ClinicalTrials.gov number, NCT01375257.
KW - Cardiovascular disease
KW - Endocarditis
KW - Health status
KW - Risk factor and mortality
U2 - 10.1007/s11136-022-03126-x
DO - 10.1007/s11136-022-03126-x
M3 - Journal article
C2 - 35349038
AN - SCOPUS:85127304001
VL - 31
SP - 2655
EP - 2662
JO - Quality of Life Research
JF - Quality of Life Research
SN - 0962-9343
ER -
ID: 305716105