Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction. Rationale and design of the EURO-ICE trial
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Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction. Rationale and design of the EURO-ICE trial. / Farissi, Mohamed El; Keulards, Danielle C.J.; van ‘t Veer, Marcel; Zelis, Jo M.; Berry, Colin; de Bruyne, Bernard; Engstrøm, Thomas; Fröbert, Ole; Piroth, Zsolth; Oldroyd, Keith G.; Tonino, Pim A.L.; Pijls, Nico H.J.; Otterspoor, Luuk C.
I: EuroIntervention, Bind 16, Nr. 17, 04.2021, s. 1444-1446.Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt
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TY - JOUR
T1 - Selective intracoronary hypothermia in patients with ST-elevation myocardial infarction. Rationale and design of the EURO-ICE trial
AU - Farissi, Mohamed El
AU - Keulards, Danielle C.J.
AU - van ‘t Veer, Marcel
AU - Zelis, Jo M.
AU - Berry, Colin
AU - de Bruyne, Bernard
AU - Engstrøm, Thomas
AU - Fröbert, Ole
AU - Piroth, Zsolth
AU - Oldroyd, Keith G.
AU - Tonino, Pim A.L.
AU - Pijls, Nico H.J.
AU - Otterspoor, Luuk C.
N1 - Funding Information: The EURO-ICE trial is an investigator-initiated trial without any commercial purpose or pursuit of profit by the sponsor of the study, Cathreine B.V. The trial is financed by a research grant from Abbott. Their support remains limited to funding only, with no influence on study design, data collection or analysis, or final manuscript publication. Publisher Copyright: © Europa Digital & Publishing 2021. All rights reserved.
PY - 2021/4
Y1 - 2021/4
N2 - In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes1. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury2. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS3. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI4. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method. Methods STUDY OBJECTIVES The primary objective of the EURO-ICE trial is to evaluate the effect of selective intracoronary hypothermia (SIH) on IS.
AB - In ST-elevation myocardial infarction (STEMI), early restoration of blood flow, preferably by primary percutaneous coronary intervention (PPCI), is paramount to limit infarct size (IS) and improve long-term outcomes1. However, reperfusion by itself may also cause damage to the myocardium and increase IS. This has been termed myocardial reperfusion injury2. In animal models of acute myocardial infarction, it has been demonstrated that hypothermia decreases IS3. In contrast, human studies applying systemic cooling methods have not yet been able to confirm this protective effect. Recently, we developed a new method to provide selective intracoronary hypothermia during PPCI4. The EUROpean Intracoronary Cooling Evaluation in patients with ST-elevation myocardial infarction (EURO-ICE) trial will assess the efficacy of this method. Methods STUDY OBJECTIVES The primary objective of the EURO-ICE trial is to evaluate the effect of selective intracoronary hypothermia (SIH) on IS.
U2 - 10.4244/EIJ-D-19-00471
DO - 10.4244/EIJ-D-19-00471
M3 - Letter
C2 - 31498112
AN - SCOPUS:85104901490
VL - 16
SP - 1444
EP - 1446
JO - EuroIntervention
JF - EuroIntervention
SN - 1774-024X
IS - 17
ER -
ID: 282607967