Secular trends of allergic asthma in Danish adults. The Copenhagen Allergy Study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Secular trends of allergic asthma in Danish adults. The Copenhagen Allergy Study. / Linneberg, A; Nielsen, N H; Madsen, F; Frølund, L; Dirksen, A; Jørgensen, T.
I: Respiratory Medicine, Bind 95, Nr. 4, 04.2001, s. 258-64.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Secular trends of allergic asthma in Danish adults. The Copenhagen Allergy Study
AU - Linneberg, A
AU - Nielsen, N H
AU - Madsen, F
AU - Frølund, L
AU - Dirksen, A
AU - Jørgensen, T
PY - 2001/4
Y1 - 2001/4
N2 - Numerous studies have reported increases in asthma prevalence among children world-wide. Less is known about similar trends in adults. We aimed to investigate whether the prevalence of allergic asthma symptoms had increased in an adult general population. Two cross-sectional surveys using identical methods were carried out in 1989 and 1998. A one-page questionnaire on respiratory symptoms was mailed to random samples of 15-41-year-olds living in Copenhagen. The response rates were 86.6% (3624/4185) and 78.8% (2402/3048) in 1989 and 1998, respectively. The questionnaire was validated with specific immunoglobilin E (IgE) positivity as the reference in a random sample of responders in connection with both surveys. We found a significantly increased prevalence of subjects who reported shortness of breath on exposure to pollens (6.6% 0 s. 10.3%, odds ratio 1.61, 95% CI 1.34-1.95), furry animals (5.4% vs. 7.6%, odds ratio 1.45, 95% CI 1.17-1.79), and house dust (7.8% vs. 10.2%, odds ratio 1.35, 95% CI 1.12-1.61). The validation of these symptoms showed that the positive predictive values were reasonably stable over time, which may support that a true increase in allergic asthma has occurred. In conclusion, the prevalence of allergic asthma symptoms increased significantly in this adult general population over a 9-year period.
AB - Numerous studies have reported increases in asthma prevalence among children world-wide. Less is known about similar trends in adults. We aimed to investigate whether the prevalence of allergic asthma symptoms had increased in an adult general population. Two cross-sectional surveys using identical methods were carried out in 1989 and 1998. A one-page questionnaire on respiratory symptoms was mailed to random samples of 15-41-year-olds living in Copenhagen. The response rates were 86.6% (3624/4185) and 78.8% (2402/3048) in 1989 and 1998, respectively. The questionnaire was validated with specific immunoglobilin E (IgE) positivity as the reference in a random sample of responders in connection with both surveys. We found a significantly increased prevalence of subjects who reported shortness of breath on exposure to pollens (6.6% 0 s. 10.3%, odds ratio 1.61, 95% CI 1.34-1.95), furry animals (5.4% vs. 7.6%, odds ratio 1.45, 95% CI 1.17-1.79), and house dust (7.8% vs. 10.2%, odds ratio 1.35, 95% CI 1.12-1.61). The validation of these symptoms showed that the positive predictive values were reasonably stable over time, which may support that a true increase in allergic asthma has occurred. In conclusion, the prevalence of allergic asthma symptoms increased significantly in this adult general population over a 9-year period.
KW - Adolescent
KW - Adult
KW - Allergens
KW - Animals
KW - Animals, Domestic
KW - Asthma
KW - Cats
KW - Confidence Intervals
KW - Cross-Sectional Studies
KW - Denmark
KW - Dogs
KW - Dust
KW - Female
KW - Humans
KW - Immunoglobulin E
KW - Logistic Models
KW - Male
KW - Odds Ratio
KW - Pollen
KW - Predictive Value of Tests
KW - Prevalence
KW - Rhinitis, Allergic, Perennial
KW - Rhinitis, Allergic, Seasonal
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1053/rmed.2001.1031
DO - 10.1053/rmed.2001.1031
M3 - Journal article
C2 - 11316107
VL - 95
SP - 258
EP - 264
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
IS - 4
ER -
ID: 173164211