Secretion of parathyroid hormone may be coupled to insulin secretion in humans
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Secretion of parathyroid hormone may be coupled to insulin secretion in humans. / Sass, Marie Reeberg; Albrechtsen, Nicolai Jacob Wewer; Pedersen, Jens; Hare, Kristine Juul; Borbye-Lorenzen, Nis; Kiss, Katalin; Vilsbøll, Tina; Knop, Filip Krag; Poulsen, Steen Seier; Jørgensen, Niklas Rye; Holst, Jens Juul; Ørskov, Cathrine; Hartmann, Bolette.
I: Endocrine Connections, Bind 9, Nr. 7, 2020, s. 747-754.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Secretion of parathyroid hormone may be coupled to insulin secretion in humans
AU - Sass, Marie Reeberg
AU - Albrechtsen, Nicolai Jacob Wewer
AU - Pedersen, Jens
AU - Hare, Kristine Juul
AU - Borbye-Lorenzen, Nis
AU - Kiss, Katalin
AU - Vilsbøll, Tina
AU - Knop, Filip Krag
AU - Poulsen, Steen Seier
AU - Jørgensen, Niklas Rye
AU - Holst, Jens Juul
AU - Ørskov, Cathrine
AU - Hartmann, Bolette
PY - 2020
Y1 - 2020
N2 - Objective: Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown. We hypothesized that insulin acts as an acute regulator of PTH secretion.Methods: Intact PTH was measured in plasma from patients with T1D and matched healthy individuals during 4-h oral glucose tolerance tests (OGTT) and isoglycemic i.v. glucose infusions on 2 separate days. In addition, expression of insulin receptors on surgical specimens of parathyroid glands was assessed by immunochemistry (IHC) and quantitative PCR (qPCR).Results: The inhibition of PTH secretion was more pronounced in healthy individuals compared to patients with T1D during an OGTT (decremental AUC(0-240min): -5256 +/- 3954 min x ng/L and -2408 +/- 1435 min x ng/L, P = 0.030). Insulin levels correlated significantly and inversely with PTH levels, also after adjusting for levels of several gut hormones and BMI (P = 0.002). Expression of insulin receptors in human parathyroid glands was detected by both IHC and qPCR.Conclusion: Our study suggests that insulin may act as an acute regulator of PTH secretion in humans.
AB - Objective: Parathyroid hormone (PTH) is a key hormone in regulation of calcium homeostasis and its secretion is regulated by calcium. Secretion of PTH is attenuated during intake of nutrients, but the underlying mechanism(s) are unknown. We hypothesized that insulin acts as an acute regulator of PTH secretion.Methods: Intact PTH was measured in plasma from patients with T1D and matched healthy individuals during 4-h oral glucose tolerance tests (OGTT) and isoglycemic i.v. glucose infusions on 2 separate days. In addition, expression of insulin receptors on surgical specimens of parathyroid glands was assessed by immunochemistry (IHC) and quantitative PCR (qPCR).Results: The inhibition of PTH secretion was more pronounced in healthy individuals compared to patients with T1D during an OGTT (decremental AUC(0-240min): -5256 +/- 3954 min x ng/L and -2408 +/- 1435 min x ng/L, P = 0.030). Insulin levels correlated significantly and inversely with PTH levels, also after adjusting for levels of several gut hormones and BMI (P = 0.002). Expression of insulin receptors in human parathyroid glands was detected by both IHC and qPCR.Conclusion: Our study suggests that insulin may act as an acute regulator of PTH secretion in humans.
KW - T1DM
KW - insulin receptor
KW - IGF1 receptor
KW - IGF2 receptor
KW - OGTT
KW - IIGI
KW - ORAL GLUCOSE-LOAD
KW - INHIBITS BONE-RESORPTION
KW - PHOSPHORUS HOMEOSTASIS
KW - PHOSPHATE-METABOLISM
KW - RECEPTOR EXPRESSION
KW - CALCIUM
KW - TURNOVER
KW - PTH
KW - HYPERINSULINEMIA
KW - LOCALIZATION
U2 - 10.1530/EC-20-0092
DO - 10.1530/EC-20-0092
M3 - Journal article
C2 - 32698134
VL - 9
SP - 747
EP - 754
JO - Endocrine Connections
JF - Endocrine Connections
SN - 2049-3614
IS - 7
ER -
ID: 247687616