Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo
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Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo. / Sorrosal, Georgina; Pérez, Lidia; Herranz, Héctor; Milán, Marco.
I: E M B O Reports, Bind 11, Nr. 5, 2010, s. 373-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Scarface, a secreted serine protease-like protein, regulates polarized localization of laminin A at the basement membrane of the Drosophila embryo
AU - Sorrosal, Georgina
AU - Pérez, Lidia
AU - Herranz, Héctor
AU - Milán, Marco
PY - 2010
Y1 - 2010
N2 - Cell-matrix interactions brought about by the activity of integrins and laminins maintain the polarized architecture of epithelia and mediate morphogenetic interactions between apposing tissues. Although the polarized localization of laminins at the basement membrane is a crucial step in these processes, little is known about how this polarized distribution is achieved. Here, in Drosophila, we analyse the role of the secreted serine protease-like protein Scarface in germ-band retraction and dorsal closure-morphogenetic processes that rely on the activity of integrins and laminins. We present evidence that scarface is regulated by c-Jun amino-terminal kinase and that scarface mutant embryos show defects in these morphogenetic processes. Anomalous accumulation of laminin A on the apical surface of epithelial cells was observed in these embryos before a loss of epithelial polarity was induced. We propose that Scarface has a key role in regulating the polarized localization of laminin A in this developmental context.
AB - Cell-matrix interactions brought about by the activity of integrins and laminins maintain the polarized architecture of epithelia and mediate morphogenetic interactions between apposing tissues. Although the polarized localization of laminins at the basement membrane is a crucial step in these processes, little is known about how this polarized distribution is achieved. Here, in Drosophila, we analyse the role of the secreted serine protease-like protein Scarface in germ-band retraction and dorsal closure-morphogenetic processes that rely on the activity of integrins and laminins. We present evidence that scarface is regulated by c-Jun amino-terminal kinase and that scarface mutant embryos show defects in these morphogenetic processes. Anomalous accumulation of laminin A on the apical surface of epithelial cells was observed in these embryos before a loss of epithelial polarity was induced. We propose that Scarface has a key role in regulating the polarized localization of laminin A in this developmental context.
KW - Animals
KW - Basement Membrane
KW - Body Patterning
KW - Cell Adhesion
KW - Cell Polarity
KW - Drosophila Proteins
KW - Drosophila melanogaster
KW - Embryo, Nonmammalian
KW - JNK Mitogen-Activated Protein Kinases
KW - Laminin
KW - Pseudopodia
KW - Serine Proteases
U2 - 10.1038/embor.2010.43
DO - 10.1038/embor.2010.43
M3 - Journal article
C2 - 20379222
VL - 11
SP - 373
EP - 379
JO - E M B O Reports
JF - E M B O Reports
SN - 1469-221X
IS - 5
ER -
ID: 119179414