TY - JOUR

T1 - Role of the Gut Microbiota in Atopic Dermatitis

T2 - A Systematic Review

AU - Petersen, Elisabeth B M

AU - Skov, Lone

AU - Thyssen, Jacob P

AU - Jensen, Peter

PY - 2019

Y1 - 2019

N2 - The immune mechanisms involved in atopic dermatitis (AD) are complex and little is known about the possible role of the gut microbiota in the aetiopathogenesis of AD. A systematic review of the literature was performed according to PRISMA guidelines, and included 44 of 2,199 studies (26 observational and 18 interventional studies). Detection of gut microbiota was performed by either 16s rRNA PCR, or by culture. Observational studies were diverse regarding the age of study participants and the bacterial species investigated. Overall, the results were conflicting with regard to diversity of the gut microbiota, specific bacterial colonization, and subsequent risk of AD. Nearly half of the included interventional studies showed that an altered gut microbial colonization due to use of probiotics had a positive effect on the severity of AD. The remaining studies did not show an effect of probiotics on the severity of AD despite an alteration in the gut microbial composition. The role of the gut microbiome for the onset and severity of pre-existing AD remains controversial.

AB - The immune mechanisms involved in atopic dermatitis (AD) are complex and little is known about the possible role of the gut microbiota in the aetiopathogenesis of AD. A systematic review of the literature was performed according to PRISMA guidelines, and included 44 of 2,199 studies (26 observational and 18 interventional studies). Detection of gut microbiota was performed by either 16s rRNA PCR, or by culture. Observational studies were diverse regarding the age of study participants and the bacterial species investigated. Overall, the results were conflicting with regard to diversity of the gut microbiota, specific bacterial colonization, and subsequent risk of AD. Nearly half of the included interventional studies showed that an altered gut microbial colonization due to use of probiotics had a positive effect on the severity of AD. The remaining studies did not show an effect of probiotics on the severity of AD despite an alteration in the gut microbial composition. The role of the gut microbiome for the onset and severity of pre-existing AD remains controversial.

KW - Bacteria/classification

KW - Dermatitis, Atopic/epidemiology

KW - Gastrointestinal Microbiome

KW - Gastrointestinal Tract/microbiology

KW - Host-Pathogen Interactions

KW - Humans

KW - Probiotics/therapeutic use

KW - Ribotyping

KW - Risk Factors

KW - Severity of Illness Index

U2 - 10.2340/00015555-3008

DO - 10.2340/00015555-3008

M3 - Review

C2 - 30085318

VL - 99

SP - 5

EP - 11

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 1

ER -