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Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder. / Demontis, Ditte; Walters, Raymond K.; Rajagopal, Veera M.; Waldman, Irwin D.; Grove, Jakob; Als, Thomas D.; Dalsgaard, Søren; Ribasas, Marta; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Maria; Werge, Thomas; Nordentoft, Merete; Mors, Ole; Mortensen, Preben Bo; Andreassen, Ole A.; Arranz, Maria Jesús; Banaschewski, Tobias; Bau, Claiton; Bellgrove, Mark; Biederman, Joseph; Brikell, Isabell; Buitelaar, Jan K.; Burton, Christie L.; Casas, Miguel; Crosbie, Jennifer; Doyle, Alysa E.; Ebstein, Richard P.; Elia, Josephine; Elizabeth, Corfield C.; Grevet, Eugenio; Grizenko, Natalie; Havdahl, Alexandra; Hawi, Ziarih; Hebebrand, Johannes; Hervas, Amaia; Hohmann, Sarah; Haavik, Jan; Joober, Ridha; Kent, Lindsey; Kuntsi, Jonna; Langley, Kate; Larsson, Henrik; Lesch, Klaus Peter; Leung, Patrick W.L.; Liao, Calwing; Loo, Sandra K.; Martin, Joanna; Martin, Nicholas G.; Medland, Sarah E.; Miranda, Ana; ADHD Working Group of the Psychiatric Genomics Consortium (PGC).
I:
Nature Communications, Bind 12, 576, 2021.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
Demontis, D, Walters, RK, Rajagopal, VM, Waldman, ID, Grove, J, Als, TD, Dalsgaard, S, Ribasas, M, Bybjerg-Grauholm, J, Bækvad-Hansen, M
, Werge, T, Nordentoft, M, Mors, O, Mortensen, PB, Andreassen, OA, Arranz, MJ, Banaschewski, T, Bau, C, Bellgrove, M, Biederman, J, Brikell, I, Buitelaar, JK, Burton, CL, Casas, M, Crosbie, J, Doyle, AE, Ebstein, RP, Elia, J, Elizabeth, CC, Grevet, E, Grizenko, N, Havdahl, A, Hawi, Z, Hebebrand, J, Hervas, A, Hohmann, S, Haavik, J, Joober, R, Kent, L, Kuntsi, J, Langley, K
, Larsson, H, Lesch, KP, Leung, PWL, Liao, C, Loo, SK, Martin, J, Martin, NG, Medland, SE, Miranda, A & ADHD Working Group of the Psychiatric Genomics Consortium (PGC) 2021, '
Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder',
Nature Communications, bind 12, 576.
https://doi.org/10.1038/s41467-020-20443-2APA
Demontis, D., Walters, R. K., Rajagopal, V. M., Waldman, I. D., Grove, J., Als, T. D., Dalsgaard, S., Ribasas, M., Bybjerg-Grauholm, J., Bækvad-Hansen, M.
, Werge, T., Nordentoft, M., Mors, O., Mortensen, P. B., Andreassen, O. A., Arranz, M. J., Banaschewski, T., Bau, C., Bellgrove, M., ... ADHD Working Group of the Psychiatric Genomics Consortium (PGC) (2021).
Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.
Nature Communications,
12, [576].
https://doi.org/10.1038/s41467-020-20443-2Vancouver
Demontis D, Walters RK, Rajagopal VM, Waldman ID, Grove J, Als TD o.a.
Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.
Nature Communications. 2021;12. 576.
https://doi.org/10.1038/s41467-020-20443-2Author
Demontis, Ditte ; Walters, Raymond K. ; Rajagopal, Veera M. ; Waldman, Irwin D. ; Grove, Jakob ; Als, Thomas D. ; Dalsgaard, Søren ; Ribasas, Marta ; Bybjerg-Grauholm, Jonas ; Bækvad-Hansen, Maria ; Werge, Thomas ; Nordentoft, Merete ; Mors, Ole ; Mortensen, Preben Bo ; Andreassen, Ole A. ; Arranz, Maria Jesús ; Banaschewski, Tobias ; Bau, Claiton ; Bellgrove, Mark ; Biederman, Joseph ; Brikell, Isabell ; Buitelaar, Jan K. ; Burton, Christie L. ; Casas, Miguel ; Crosbie, Jennifer ; Doyle, Alysa E. ; Ebstein, Richard P. ; Elia, Josephine ; Elizabeth, Corfield C. ; Grevet, Eugenio ; Grizenko, Natalie ; Havdahl, Alexandra ; Hawi, Ziarih ; Hebebrand, Johannes ; Hervas, Amaia ; Hohmann, Sarah ; Haavik, Jan ; Joober, Ridha ; Kent, Lindsey ; Kuntsi, Jonna ; Langley, Kate ; Larsson, Henrik ; Lesch, Klaus Peter ; Leung, Patrick W.L. ; Liao, Calwing ; Loo, Sandra K. ; Martin, Joanna ; Martin, Nicholas G. ; Medland, Sarah E. ; Miranda, Ana ; ADHD Working Group of the Psychiatric Genomics Consortium (PGC). / Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder. I: Nature Communications. 2021 ; Bind 12.
Bibtex
@article{0215f780263947859c1fc61aac418922,
title = "Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder",
abstract = "Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.",
author = "Ditte Demontis and Walters, {Raymond K.} and Rajagopal, {Veera M.} and Waldman, {Irwin D.} and Jakob Grove and Als, {Thomas D.} and S{\o}ren Dalsgaard and Marta Ribasas and Jonas Bybjerg-Grauholm and Maria B{\ae}kvad-Hansen and Thomas Werge and Merete Nordentoft and Ole Mors and Mortensen, {Preben Bo} and Andreassen, {Ole A.} and Arranz, {Maria Jes{\'u}s} and Tobias Banaschewski and Claiton Bau and Mark Bellgrove and Joseph Biederman and Isabell Brikell and Buitelaar, {Jan K.} and Burton, {Christie L.} and Miguel Casas and Jennifer Crosbie and Doyle, {Alysa E.} and Ebstein, {Richard P.} and Josephine Elia and Elizabeth, {Corfield C.} and Eugenio Grevet and Natalie Grizenko and Alexandra Havdahl and Ziarih Hawi and Johannes Hebebrand and Amaia Hervas and Sarah Hohmann and Jan Haavik and Ridha Joober and Lindsey Kent and Jonna Kuntsi and Kate Langley and Henrik Larsson and Lesch, {Klaus Peter} and Leung, {Patrick W.L.} and Calwing Liao and Loo, {Sandra K.} and Joanna Martin and Martin, {Nicholas G.} and Medland, {Sarah E.} and Ana Miranda and {ADHD Working Group of the Psychiatric Genomics Consortium (PGC)}",
note = "Author Correction. DOI: 10.1038/s41467-020-20443-2",
year = "2021",
doi = "10.1038/s41467-020-20443-2",
language = "English",
volume = "12",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
AU - Demontis, Ditte
AU - Walters, Raymond K.
AU - Rajagopal, Veera M.
AU - Waldman, Irwin D.
AU - Grove, Jakob
AU - Als, Thomas D.
AU - Dalsgaard, Søren
AU - Ribasas, Marta
AU - Bybjerg-Grauholm, Jonas
AU - Bækvad-Hansen, Maria
AU - Werge, Thomas
AU - Nordentoft, Merete
AU - Mors, Ole
AU - Mortensen, Preben Bo
AU - Andreassen, Ole A.
AU - Arranz, Maria Jesús
AU - Banaschewski, Tobias
AU - Bau, Claiton
AU - Bellgrove, Mark
AU - Biederman, Joseph
AU - Brikell, Isabell
AU - Buitelaar, Jan K.
AU - Burton, Christie L.
AU - Casas, Miguel
AU - Crosbie, Jennifer
AU - Doyle, Alysa E.
AU - Ebstein, Richard P.
AU - Elia, Josephine
AU - Elizabeth, Corfield C.
AU - Grevet, Eugenio
AU - Grizenko, Natalie
AU - Havdahl, Alexandra
AU - Hawi, Ziarih
AU - Hebebrand, Johannes
AU - Hervas, Amaia
AU - Hohmann, Sarah
AU - Haavik, Jan
AU - Joober, Ridha
AU - Kent, Lindsey
AU - Kuntsi, Jonna
AU - Langley, Kate
AU - Larsson, Henrik
AU - Lesch, Klaus Peter
AU - Leung, Patrick W.L.
AU - Liao, Calwing
AU - Loo, Sandra K.
AU - Martin, Joanna
AU - Martin, Nicholas G.
AU - Medland, Sarah E.
AU - Miranda, Ana
AU - ADHD Working Group of the Psychiatric Genomics Consortium (PGC)
N1 - Author Correction. DOI: 10.1038/s41467-020-20443-2
PY - 2021
Y1 - 2021
N2 - Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.
AB - Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10−10, OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h2SNP = 0.34) when compared to ADHD without DBDs (h2SNP = 0.20), high genetic correlations between ADHD + DBDs and aggressive (rg = 0.81) and anti-social behaviors (rg = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.
U2 - 10.1038/s41467-020-20443-2
DO - 10.1038/s41467-020-20443-2
M3 - Journal article
C2 - 33495439
AN - SCOPUS:85099802296
VL - 12
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 576
ER -
