TY - JOUR

T1 - Risk of Myocardial Infarction in Patients with Psoriasis and Psoriatic Arthritis

T2 - A Nationwide Cohort Study

AU - Egeberg, Alexander

AU - Thyssen, Jacob P

AU - Jensen, Peter

AU - Gislason, Gunnar H

AU - Skov, Lone

PY - 2017/7/6

Y1 - 2017/7/6

N2 - Psoriasis has been associated with increased risk of myocardial infarction (MI) in some, but not all, studies. This study investigated the risk of MI in patients with psoriasis and psoriatic arthritis in Denmark. All residents aged ≥18 years from 1 January 2008 through 31 December 2012 were included. Adjusted hazard ratios (HRs) did not show an increased risk of MI in patients with mild psoriasis (HR 1.02; 95% confidence interval (95% CI) 0.96-1.09), whereas the risk was slightly increased in patients with severe psoriasis (HR 1.21; 1.07-1.37). Stratified by age, there was no increased risk of MI in any specific age group, regardless of severity. Limited to first-time MI, the risk was increased only in patients with severe psoriasis aged <50 years (HR 1.52; 1.03-2.25). The same applied to patients without psoriatic arthritis (severe psoriasis aged <50 years; HR 1.74; 1.11-2.72). In analyses restricted to patients with psoriatic arthritis, age-specific strata did not show any association between psoriatic arthritis and MI risk.

AB - Psoriasis has been associated with increased risk of myocardial infarction (MI) in some, but not all, studies. This study investigated the risk of MI in patients with psoriasis and psoriatic arthritis in Denmark. All residents aged ≥18 years from 1 January 2008 through 31 December 2012 were included. Adjusted hazard ratios (HRs) did not show an increased risk of MI in patients with mild psoriasis (HR 1.02; 95% confidence interval (95% CI) 0.96-1.09), whereas the risk was slightly increased in patients with severe psoriasis (HR 1.21; 1.07-1.37). Stratified by age, there was no increased risk of MI in any specific age group, regardless of severity. Limited to first-time MI, the risk was increased only in patients with severe psoriasis aged <50 years (HR 1.52; 1.03-2.25). The same applied to patients without psoriatic arthritis (severe psoriasis aged <50 years; HR 1.74; 1.11-2.72). In analyses restricted to patients with psoriatic arthritis, age-specific strata did not show any association between psoriatic arthritis and MI risk.

KW - Adult

KW - Age Distribution

KW - Aged

KW - Arthritis, Psoriatic/diagnosis

KW - Denmark/epidemiology

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/diagnosis

KW - Odds Ratio

KW - Prognosis

KW - Proportional Hazards Models

KW - Psoriasis/diagnosis

KW - Retrospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Severity of Illness Index

KW - Time Factors

U2 - 10.2340/00015555-2657

DO - 10.2340/00015555-2657

M3 - Journal article

C2 - 28350413

VL - 97

SP - 819

EP - 824

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

SN - 0001-5555

IS - 7

ER -