Risk of cancer by transferrin saturation levels and haemochromatosis genotype: population-based study and meta-analysis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Abstract. Ellervik C, Tybjaerg-Hansen A, Nordestgaard BG (Herlev Hospital, Herlev; Naestved Hospital, Naestved; Copenhagen University Hospitals and Faculty of Health Sciences, Copenhagen; Rigshospitalet, Copenhagen; The Copenhagen City Heart Study, Bispebjerg Hospital, University of Copenhagen, Copenhagen, Denmark). Risk of cancer by transferrin saturation levels and haemochromatosis genotype: population-based study and meta-analysis. J Intern Med 2011; doi: 10.1111/j.1365-2796.2011.02404.x. Objective. Increased iron overload, whether or not owing to the presence of the haemochromatosis genotype C282Y/C282Y, may be associated with an increased risk of cancer. The aim of this study was to test the hypothesis that elevated transferrin saturation levels (as a proxy for iron overload) and haemochromatosis genotype C282Y/C282Y are associated with an increased risk of cancer. Methods. We conducted a population-based study of 8763 individuals, of whom 1417 developed a first cancer during 15 years of follow-up, and a meta-analysis. We stratified absolute 10-year risk of cancer by smoking status, an important risk factor. Results. In women, transferrin saturation above 60% versus below 50% was associated with a hazard ratio of 3.6 (95% confidence interval (CI): 2.0-6.5; P
Originalsprog | Engelsk |
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Tidsskrift | Journal of Internal Medicine |
Vol/bind | 271 |
Udgave nummer | 1 |
Sider (fra-til) | 51-63 |
Antal sider | 13 |
ISSN | 0954-6820 |
DOI | |
Status | Udgivet - 2012 |
ID: 34522304