Risk of asthma in offspring of asthmatic fathers versus mothers: A population-based study of 21,000 individuals in Denmark
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Risk of asthma in offspring of asthmatic fathers versus mothers : A population-based study of 21,000 individuals in Denmark. / Al-Shuweli, Suzan; Landt, Eskild; Ellervik, Christina; Poulsen, Henrik Enghusen; Ramar, Mohankumar; Dahl, Morten; Fedulov, Alexey V.
I: Respiratory Medicine, Bind 207, 107116, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Risk of asthma in offspring of asthmatic fathers versus mothers
T2 - A population-based study of 21,000 individuals in Denmark
AU - Al-Shuweli, Suzan
AU - Landt, Eskild
AU - Ellervik, Christina
AU - Poulsen, Henrik Enghusen
AU - Ramar, Mohankumar
AU - Dahl, Morten
AU - Fedulov, Alexey V.
N1 - Publisher Copyright: © 2023 Elsevier Ltd
PY - 2023
Y1 - 2023
N2 - Parental asthma or allergy have been linked to higher risk of asthma in a child; this occurs to a variable extent in different study populations. Moreover, it is debated whether maternal more so than paternal asthma history is a stronger predisposing factor: while in some countries/populations the maternal effect was clearly seen over paternal, in others the parental effects were equivalent, and in a few studies paternal effect dominated. Here we aimed to determine parental asthma and allergy effect in the Danish GEneral SUburban population Study (GESUS). This cross-sectional study has involved 21,362 adults aged 20+ years in the suburbs of Copenhagen. We used a combination of questionnaire approach, history of prescribed asthma medications and pulmonary function testing to determine odds ratios for maternal and paternal (and combined) asthma and allergy linked to asthma in the test subjects. We found that the input of maternal vs. paternal asthma effect was approximately equal (age and sex-adjusted OR 2.46, 95% CI: 2.15–2.81 for asthmatic mothers vs. 2.97, 2.58–3.42 for asthmatic fathers), except for the “ever asthma” age and sex-adjusted odds ratios where paternal allergy seems to have conferred a marginally greater effect (age and sex-adj. OR 1.96 for maternal allergy vs. 2.44 for paternal allergy, p = 0.03). Stratifying for gestational tobacco smoking did not affect the maternal results. We conclude that in the GESUS study parental asthma or allergy were strongly linked to higher asthma risk in offspring, without a prominent maternal or paternal effect.
AB - Parental asthma or allergy have been linked to higher risk of asthma in a child; this occurs to a variable extent in different study populations. Moreover, it is debated whether maternal more so than paternal asthma history is a stronger predisposing factor: while in some countries/populations the maternal effect was clearly seen over paternal, in others the parental effects were equivalent, and in a few studies paternal effect dominated. Here we aimed to determine parental asthma and allergy effect in the Danish GEneral SUburban population Study (GESUS). This cross-sectional study has involved 21,362 adults aged 20+ years in the suburbs of Copenhagen. We used a combination of questionnaire approach, history of prescribed asthma medications and pulmonary function testing to determine odds ratios for maternal and paternal (and combined) asthma and allergy linked to asthma in the test subjects. We found that the input of maternal vs. paternal asthma effect was approximately equal (age and sex-adjusted OR 2.46, 95% CI: 2.15–2.81 for asthmatic mothers vs. 2.97, 2.58–3.42 for asthmatic fathers), except for the “ever asthma” age and sex-adjusted odds ratios where paternal allergy seems to have conferred a marginally greater effect (age and sex-adj. OR 1.96 for maternal allergy vs. 2.44 for paternal allergy, p = 0.03). Stratifying for gestational tobacco smoking did not affect the maternal results. We conclude that in the GESUS study parental asthma or allergy were strongly linked to higher asthma risk in offspring, without a prominent maternal or paternal effect.
KW - Asthma
KW - Cross-sectional study
KW - Maternal
KW - Offspring
KW - Paternal
U2 - 10.1016/j.rmed.2023.107116
DO - 10.1016/j.rmed.2023.107116
M3 - Journal article
C2 - 36642344
AN - SCOPUS:85146478362
VL - 207
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
M1 - 107116
ER -
ID: 365966076