Risk factors for systemic reactions in typical cold urticaria: Results from the COLD-CE study
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Risk factors for systemic reactions in typical cold urticaria : Results from the COLD-CE study. / Bizjak, Mojca; Košnik, Mitja; Dinevski, Dejan; Thomsen, Simon Francis; Fomina, Daria; Borzova, Elena; Kulthanan, Kanokvalai; Meshkova, Raisa; Ahsan, Dalia Melina; Al-Ahmad, Mona; Altrichter, Sabine; Bauer, Andrea; Brockstädt, Maxi; Costa, Célia; Demir, Semra; Fachini Criado, Roberta; Ensina, Luis Felipe; Gelincik, Asli; Giménez-Arnau, Ana Maria; Gonçalo, Margarida; Gotua, Maia; Holm, Jesper Grønlund; Inomata, Naoko; Kasperska-Zajac, Alicja; Khoshkhui, Maryam; Klyucharova, Aliya; Kocatürk, Emek; Lu, Rongbiao; Makris, Michael; Maltseva, Natalya; Miljković, Jovan; Pasali, Maria; Paulino, Marisa; Pesqué, David; Peter, Jonny; Ramón, German Dario; Ritchie, Carla; Rodrigues Valle, Solange Oliveira; Rudenko, Michael; Sikora, Agnieszka; de Souza Lima, Eduardo M.; Wagner, Nicola; Xepapadaki, Paraskevi; Xue, Xiaoyang; Zhao, Zuotao; Terhorst-Molawi, Dorothea; Maurer, Marcus.
I: Allergy: European Journal of Allergy and Clinical Immunology, Bind 77, Nr. 7, 07.2022, s. 2185-2199.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Risk factors for systemic reactions in typical cold urticaria
T2 - Results from the COLD-CE study
AU - Bizjak, Mojca
AU - Košnik, Mitja
AU - Dinevski, Dejan
AU - Thomsen, Simon Francis
AU - Fomina, Daria
AU - Borzova, Elena
AU - Kulthanan, Kanokvalai
AU - Meshkova, Raisa
AU - Ahsan, Dalia Melina
AU - Al-Ahmad, Mona
AU - Altrichter, Sabine
AU - Bauer, Andrea
AU - Brockstädt, Maxi
AU - Costa, Célia
AU - Demir, Semra
AU - Fachini Criado, Roberta
AU - Ensina, Luis Felipe
AU - Gelincik, Asli
AU - Giménez-Arnau, Ana Maria
AU - Gonçalo, Margarida
AU - Gotua, Maia
AU - Holm, Jesper Grønlund
AU - Inomata, Naoko
AU - Kasperska-Zajac, Alicja
AU - Khoshkhui, Maryam
AU - Klyucharova, Aliya
AU - Kocatürk, Emek
AU - Lu, Rongbiao
AU - Makris, Michael
AU - Maltseva, Natalya
AU - Miljković, Jovan
AU - Pasali, Maria
AU - Paulino, Marisa
AU - Pesqué, David
AU - Peter, Jonny
AU - Ramón, German Dario
AU - Ritchie, Carla
AU - Rodrigues Valle, Solange Oliveira
AU - Rudenko, Michael
AU - Sikora, Agnieszka
AU - de Souza Lima, Eduardo M.
AU - Wagner, Nicola
AU - Xepapadaki, Paraskevi
AU - Xue, Xiaoyang
AU - Zhao, Zuotao
AU - Terhorst-Molawi, Dorothea
AU - Maurer, Marcus
N1 - Publisher Copyright: © 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
PY - 2022/7
Y1 - 2022/7
N2 - Background: Cold urticaria (ColdU), that is, the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. Methods: An international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. Results: Of 551 ColdU patients, 75% (n = 412) had a positive CST and ColdA occurred in 37% (n = 151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n = 40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs. 39%, p =.003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. Conclusion: ColdA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector.
AB - Background: Cold urticaria (ColdU), that is, the occurrence of wheals or angioedema in response to cold exposure, is classified into typical and atypical forms. The diagnosis of typical ColdU relies on whealing in response to local cold stimulation testing (CST). It can also manifest with cold-induced anaphylaxis (ColdA). We aimed to determine risk factors for ColdA in typical ColdU. Methods: An international, cross-sectional study COLD-CE was carried out at 32 urticaria centers of reference and excellence (UCAREs). Detailed history was taken and CST with an ice cube and/or TempTest® performed. ColdA was defined as an acute cold-induced involvement of the skin and/or visible mucosal tissue and at least one of: cardiovascular manifestations, difficulty breathing, or gastrointestinal symptoms. Results: Of 551 ColdU patients, 75% (n = 412) had a positive CST and ColdA occurred in 37% (n = 151) of the latter. Cold-induced generalized wheals, angioedema, acral swelling, oropharyngeal/laryngeal symptoms, and itch of earlobes were identified as signs/symptoms of severe disease. ColdA was most commonly provoked by complete cold water immersion and ColdA caused by cold air was more common in countries with a warmer climate. Ten percent (n = 40) of typical ColdU patients had a concomitant chronic spontaneous urticaria (CSU). They had a lower frequency of ColdA than those without CSU (4% vs. 39%, p =.003). We identified the following risk factors for cardiovascular manifestations: previous systemic reaction to a Hymenoptera sting, angioedema, oropharyngeal/laryngeal symptoms, and itchy earlobes. Conclusion: ColdA is common in typical ColdU. High-risk patients require education about their condition and how to use an adrenaline autoinjector.
KW - adrenaline autoinjector
KW - cold urticaria
KW - COLD-CE
KW - risk factors
KW - systemic reactions
UR - http://www.scopus.com/inward/record.url?scp=85121601539&partnerID=8YFLogxK
U2 - 10.1111/all.15194
DO - 10.1111/all.15194
M3 - Journal article
C2 - 34862605
AN - SCOPUS:85121601539
VL - 77
SP - 2185
EP - 2199
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 7
ER -
ID: 342928856