Ride the wave: Retrograde trafficking becomes Ca(2+) dependent with BAIAP3
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- Ride the wave: Retrograde trafficking becomes Ca2+ dependent with BAIAP3
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The functions of four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as priming factors in SNARE-dependent exocytosis. In this issue, Zhang et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201702099) show that the fifth member, BAIAP3 (brain-specific angiogenesis inhibitor I-associated protein 3), acts in retrograde trafficking by returning secretory vesicle material to the trans-Golgi network. In its absence, secretory vesicle formation is impaired, leading to accumulation of immature vesicles, or lysosomal vesicle degradation.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Cell Biology |
Vol/bind | 216 |
Udgave nummer | 7 |
Sider (fra-til) | 1887-1889 |
Antal sider | 3 |
ISSN | 0021-9525 |
DOI |
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Status | Udgivet - 2017 |
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ID: 185030281