Standard
Rhinitis associated with asthma is distinct from rhinitis alone : The ARIA-MeDALL hypothesis. / Bousquet, J; Melén, E; Haahtela, T; Koppelman, G H; Togias, A; Valenta, R; Akdis, C A; Czarlewski, W; Rothenberg, M; Valiulis, A; Wickman, M; Akdis, M; Aguilar, D; Bedbrook, A; Bindslev-Jensen, C; Bosnic-Anticevich, S; Boulet, L P; Brightling, C E; Brussino, L; Burte, E; Bustamante, M; Canonica, G W; Cecchi, L; Celedon, J C; Chaves Loureiro, C; Costa, E; Cruz, A A; Erhola, M; Gemicioglu, B; Fokkens, W J; Garcia-Aymerich, J; Guerra, S; Heinrich, J; Ivancevich, J C; Keil, T; Klimek, L; Kuna, P; Kupczyk, M; Kvedariene, V; Larenas-Linnemann, D E; Lemonnier, N; Lodrup Carlsen, K C; Louis, R; Makela, M; Makris, M; Maurer, M; Momas, I; Morais-Almeida, M; Mullol, J; Naclerio, R N; Nadeau, K; Nadif, R; Niedoszytko, M; Okamoto, Y; Ollert, M; Papadopoulos, N G; Passalacqua, G; Patella, V; Pawankar, R; Pham-Thi, N; Pfaar, O; Regateiro, F S; Ring, J; Rouadi, P W; Samolinski, B; Sastre, J; Savouré, M; Scichilone, N; Shamji, M H; Sheikh, A; Siroux, V; Sousa-Pinto, B; Standl, M; Sunyer, J; Taborda-Barata, L; Toppila-Salmi, S; Torres, M J; Tsiligianni, I; Valovirta, E; Vandenplas, O; Ventura, M T; Weiss, S; Yorgancioglu, A; Zhang, L; Abdul Latiff, A H; Aberer, W; Agache, I; Al-Ahmad, M; Alobid, I; Ansotegui, I J; Arshad, S H; Asayag, E; Barbara, C; Baharudin, A; Battur, L; Bennoor, K S; Berghea, E C; Bergmann, K C; Bernstein, D; Bewick, M; Blain, H; Bonini, M; Braido, F; Buhl, R; Bumbacea, R S; Bush, A; Calderon, M; Calvo-Gil, M; Camargos, P; Caraballo, L; Cardona, V; Carr, W; Carreiro-Martins, P; Casale, T; Cepeda Sarabia, A M; Chandrasekharan, R; Charpin, D; Chen, Y Z; Cherrez-Ojeda, I; Chivato, T; Chkhartishvili, E; Christoff, G; Chu, D K; Cingi, C; Correia de Sousa, J; Corrigan, C; Custovic, A; D'Amato, G; Del Giacco, S; De Blay, F; Devillier, P; Didier, A; do Ceu Teixeira, M; Dokic, D; Douagui, H; Doulaptsi, M; Durham, S; Dykewicz, M; Eiwegger, T; El-Sayed, Z A; Emuzyte, R; Fiocchi, A; Fyhrquist, N; Gomez, R M; Gotua, M; Guzman, M A; Hagemann, J; Hamamah, S; Halken, S; Halpin, D M G; Hofmann, M; Hossny, E; Hrubiško, M; Irani, C; Ispayeva, Z; Jares, E; Jartti, T; Jassem, E; Julge, K; Just, J; Jutel, M; Kaidashev, I; Kalayci, O; Kalyoncu, A F; Kardas, P; Kirenga, B; Kraxner, H; Kull, I; Kulus, M; La Grutta, S; Lau, S; Le Tuyet Thi, L; Levin, M; Lipworth, B; Lourenço, O; Mahboub, B; Martinez-Infante, E; Matricardi, P; Miculinic, N; Migueres, N; Mihaltan, F; Mohammad, Y; Moniuszko, M; Montefort, S; Neffen, H; Nekam, K; Nunes, E; Nyembue Tshipukane, D; O'Hehir, R; Ogulur, I; Ohta, K; Okubo, K; Ouedraogo, S; Olze, H; Pali-Schöll, I; Palomares, O; Palosuo, K; Panaitescu, C; Panzner, P; Park, H S; Pitsios, C; Plavec, D; Popov, T A; Puggioni, F; Quirce, S; Recto, M; Repka-Ramirez, M S; Robalo Cordeiro, C; Roche, N; Rodriguez-Gonzalez, M; Romantowski, J; Rosario Filho, N; Rottem, M; Sagara, H; Serpa, F S; Sayah, Z; Scheire, S; Schmid-Grendelmeier, P; Sisul, J C; Sole, D; Soto-Martinez, M; Sova, M; Sperl, A; Spranger, O; Stelmach, R; Suppli Ulrik, C; Thomas, M; To, T; Todo-Bom, A; Tomazic, P V; Urrutia-Pereira, M; Valentin-Rostan, M; Van Ganse, E; van Hage, M; Vasankari, T; Vichyanond, P; Viegi, G; Wallace, D; Wang, D Y; Williams, S; Worm, M; Yiallouros, P; Yusuf, O; Zaitoun, F; Zernotti, M; Zidarn, M; Zuberbier, J; Fonseca, J A; Zuberbier, T; Anto, J M.
I:
Allergy, Bind 78, Nr. 5, 2023, s. 1169-1203.
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
Bousquet, J, Melén, E, Haahtela, T, Koppelman, GH, Togias, A, Valenta, R, Akdis, CA, Czarlewski, W, Rothenberg, M, Valiulis, A, Wickman, M, Akdis, M, Aguilar, D, Bedbrook, A, Bindslev-Jensen, C, Bosnic-Anticevich, S, Boulet, LP, Brightling, CE, Brussino, L, Burte, E, Bustamante, M, Canonica, GW, Cecchi, L, Celedon, JC, Chaves Loureiro, C, Costa, E, Cruz, AA, Erhola, M, Gemicioglu, B, Fokkens, WJ, Garcia-Aymerich, J, Guerra, S, Heinrich, J, Ivancevich, JC, Keil, T, Klimek, L, Kuna, P, Kupczyk, M, Kvedariene, V, Larenas-Linnemann, DE, Lemonnier, N, Lodrup Carlsen, KC, Louis, R, Makela, M, Makris, M, Maurer, M, Momas, I, Morais-Almeida, M, Mullol, J, Naclerio, RN, Nadeau, K, Nadif, R, Niedoszytko, M, Okamoto, Y, Ollert, M, Papadopoulos, NG, Passalacqua, G, Patella, V, Pawankar, R, Pham-Thi, N, Pfaar, O, Regateiro, FS, Ring, J, Rouadi, PW, Samolinski, B, Sastre, J, Savouré, M, Scichilone, N, Shamji, MH, Sheikh, A, Siroux, V, Sousa-Pinto, B, Standl, M, Sunyer, J, Taborda-Barata, L, Toppila-Salmi, S, Torres, MJ, Tsiligianni, I, Valovirta, E, Vandenplas, O, Ventura, MT, Weiss, S, Yorgancioglu, A, Zhang, L, Abdul Latiff, AH, Aberer, W, Agache, I, Al-Ahmad, M, Alobid, I, Ansotegui, IJ, Arshad, SH, Asayag, E, Barbara, C, Baharudin, A, Battur, L, Bennoor, KS, Berghea, EC, Bergmann, KC, Bernstein, D, Bewick, M, Blain, H, Bonini, M, Braido, F, Buhl, R, Bumbacea, RS, Bush, A, Calderon, M, Calvo-Gil, M, Camargos, P, Caraballo, L, Cardona, V, Carr, W, Carreiro-Martins, P, Casale, T, Cepeda Sarabia, AM, Chandrasekharan, R, Charpin, D, Chen, YZ, Cherrez-Ojeda, I, Chivato, T, Chkhartishvili, E, Christoff, G, Chu, DK, Cingi, C, Correia de Sousa, J, Corrigan, C, Custovic, A, D'Amato, G, Del Giacco, S, De Blay, F, Devillier, P, Didier, A, do Ceu Teixeira, M, Dokic, D, Douagui, H, Doulaptsi, M, Durham, S, Dykewicz, M, Eiwegger, T, El-Sayed, ZA, Emuzyte, R, Fiocchi, A, Fyhrquist, N, Gomez, RM, Gotua, M, Guzman, MA, Hagemann, J, Hamamah, S, Halken, S, Halpin, DMG, Hofmann, M, Hossny, E, Hrubiško, M, Irani, C, Ispayeva, Z, Jares, E, Jartti, T, Jassem, E, Julge, K, Just, J, Jutel, M, Kaidashev, I, Kalayci, O, Kalyoncu, AF, Kardas, P, Kirenga, B, Kraxner, H, Kull, I, Kulus, M, La Grutta, S, Lau, S, Le Tuyet Thi, L, Levin, M, Lipworth, B, Lourenço, O, Mahboub, B, Martinez-Infante, E, Matricardi, P, Miculinic, N, Migueres, N, Mihaltan, F, Mohammad, Y, Moniuszko, M, Montefort, S, Neffen, H, Nekam, K, Nunes, E, Nyembue Tshipukane, D, O'Hehir, R, Ogulur, I, Ohta, K, Okubo, K, Ouedraogo, S, Olze, H, Pali-Schöll, I, Palomares, O, Palosuo, K, Panaitescu, C, Panzner, P, Park, HS, Pitsios, C, Plavec, D, Popov, TA, Puggioni, F, Quirce, S, Recto, M, Repka-Ramirez, MS, Robalo Cordeiro, C, Roche, N, Rodriguez-Gonzalez, M, Romantowski, J, Rosario Filho, N, Rottem, M, Sagara, H, Serpa, FS, Sayah, Z, Scheire, S, Schmid-Grendelmeier, P, Sisul, JC, Sole, D, Soto-Martinez, M, Sova, M, Sperl, A, Spranger, O, Stelmach, R
, Suppli Ulrik, C, Thomas, M, To, T, Todo-Bom, A, Tomazic, PV, Urrutia-Pereira, M, Valentin-Rostan, M, Van Ganse, E, van Hage, M, Vasankari, T, Vichyanond, P, Viegi, G, Wallace, D, Wang, DY, Williams, S, Worm, M, Yiallouros, P, Yusuf, O, Zaitoun, F, Zernotti, M, Zidarn, M, Zuberbier, J, Fonseca, JA, Zuberbier, T & Anto, JM 2023, '
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis',
Allergy, bind 78, nr. 5, s. 1169-1203.
https://doi.org/10.1111/all.15679
APA
Bousquet, J., Melén, E., Haahtela, T., Koppelman, G. H., Togias, A., Valenta, R., Akdis, C. A., Czarlewski, W., Rothenberg, M., Valiulis, A., Wickman, M., Akdis, M., Aguilar, D., Bedbrook, A., Bindslev-Jensen, C., Bosnic-Anticevich, S., Boulet, L. P., Brightling, C. E., Brussino, L., ... Anto, J. M. (2023).
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis.
Allergy,
78(5), 1169-1203.
https://doi.org/10.1111/all.15679
Vancouver
Bousquet J, Melén E, Haahtela T, Koppelman GH, Togias A, Valenta R o.a.
Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis.
Allergy. 2023;78(5):1169-1203.
https://doi.org/10.1111/all.15679
Author
Bousquet, J ; Melén, E ; Haahtela, T ; Koppelman, G H ; Togias, A ; Valenta, R ; Akdis, C A ; Czarlewski, W ; Rothenberg, M ; Valiulis, A ; Wickman, M ; Akdis, M ; Aguilar, D ; Bedbrook, A ; Bindslev-Jensen, C ; Bosnic-Anticevich, S ; Boulet, L P ; Brightling, C E ; Brussino, L ; Burte, E ; Bustamante, M ; Canonica, G W ; Cecchi, L ; Celedon, J C ; Chaves Loureiro, C ; Costa, E ; Cruz, A A ; Erhola, M ; Gemicioglu, B ; Fokkens, W J ; Garcia-Aymerich, J ; Guerra, S ; Heinrich, J ; Ivancevich, J C ; Keil, T ; Klimek, L ; Kuna, P ; Kupczyk, M ; Kvedariene, V ; Larenas-Linnemann, D E ; Lemonnier, N ; Lodrup Carlsen, K C ; Louis, R ; Makela, M ; Makris, M ; Maurer, M ; Momas, I ; Morais-Almeida, M ; Mullol, J ; Naclerio, R N ; Nadeau, K ; Nadif, R ; Niedoszytko, M ; Okamoto, Y ; Ollert, M ; Papadopoulos, N G ; Passalacqua, G ; Patella, V ; Pawankar, R ; Pham-Thi, N ; Pfaar, O ; Regateiro, F S ; Ring, J ; Rouadi, P W ; Samolinski, B ; Sastre, J ; Savouré, M ; Scichilone, N ; Shamji, M H ; Sheikh, A ; Siroux, V ; Sousa-Pinto, B ; Standl, M ; Sunyer, J ; Taborda-Barata, L ; Toppila-Salmi, S ; Torres, M J ; Tsiligianni, I ; Valovirta, E ; Vandenplas, O ; Ventura, M T ; Weiss, S ; Yorgancioglu, A ; Zhang, L ; Abdul Latiff, A H ; Aberer, W ; Agache, I ; Al-Ahmad, M ; Alobid, I ; Ansotegui, I J ; Arshad, S H ; Asayag, E ; Barbara, C ; Baharudin, A ; Battur, L ; Bennoor, K S ; Berghea, E C ; Bergmann, K C ; Bernstein, D ; Bewick, M ; Blain, H ; Bonini, M ; Braido, F ; Buhl, R ; Bumbacea, R S ; Bush, A ; Calderon, M ; Calvo-Gil, M ; Camargos, P ; Caraballo, L ; Cardona, V ; Carr, W ; Carreiro-Martins, P ; Casale, T ; Cepeda Sarabia, A M ; Chandrasekharan, R ; Charpin, D ; Chen, Y Z ; Cherrez-Ojeda, I ; Chivato, T ; Chkhartishvili, E ; Christoff, G ; Chu, D K ; Cingi, C ; Correia de Sousa, J ; Corrigan, C ; Custovic, A ; D'Amato, G ; Del Giacco, S ; De Blay, F ; Devillier, P ; Didier, A ; do Ceu Teixeira, M ; Dokic, D ; Douagui, H ; Doulaptsi, M ; Durham, S ; Dykewicz, M ; Eiwegger, T ; El-Sayed, Z A ; Emuzyte, R ; Fiocchi, A ; Fyhrquist, N ; Gomez, R M ; Gotua, M ; Guzman, M A ; Hagemann, J ; Hamamah, S ; Halken, S ; Halpin, D M G ; Hofmann, M ; Hossny, E ; Hrubiško, M ; Irani, C ; Ispayeva, Z ; Jares, E ; Jartti, T ; Jassem, E ; Julge, K ; Just, J ; Jutel, M ; Kaidashev, I ; Kalayci, O ; Kalyoncu, A F ; Kardas, P ; Kirenga, B ; Kraxner, H ; Kull, I ; Kulus, M ; La Grutta, S ; Lau, S ; Le Tuyet Thi, L ; Levin, M ; Lipworth, B ; Lourenço, O ; Mahboub, B ; Martinez-Infante, E ; Matricardi, P ; Miculinic, N ; Migueres, N ; Mihaltan, F ; Mohammad, Y ; Moniuszko, M ; Montefort, S ; Neffen, H ; Nekam, K ; Nunes, E ; Nyembue Tshipukane, D ; O'Hehir, R ; Ogulur, I ; Ohta, K ; Okubo, K ; Ouedraogo, S ; Olze, H ; Pali-Schöll, I ; Palomares, O ; Palosuo, K ; Panaitescu, C ; Panzner, P ; Park, H S ; Pitsios, C ; Plavec, D ; Popov, T A ; Puggioni, F ; Quirce, S ; Recto, M ; Repka-Ramirez, M S ; Robalo Cordeiro, C ; Roche, N ; Rodriguez-Gonzalez, M ; Romantowski, J ; Rosario Filho, N ; Rottem, M ; Sagara, H ; Serpa, F S ; Sayah, Z ; Scheire, S ; Schmid-Grendelmeier, P ; Sisul, J C ; Sole, D ; Soto-Martinez, M ; Sova, M ; Sperl, A ; Spranger, O ; Stelmach, R ; Suppli Ulrik, C ; Thomas, M ; To, T ; Todo-Bom, A ; Tomazic, P V ; Urrutia-Pereira, M ; Valentin-Rostan, M ; Van Ganse, E ; van Hage, M ; Vasankari, T ; Vichyanond, P ; Viegi, G ; Wallace, D ; Wang, D Y ; Williams, S ; Worm, M ; Yiallouros, P ; Yusuf, O ; Zaitoun, F ; Zernotti, M ; Zidarn, M ; Zuberbier, J ; Fonseca, J A ; Zuberbier, T ; Anto, J M. / Rhinitis associated with asthma is distinct from rhinitis alone : The ARIA-MeDALL hypothesis. I: Allergy. 2023 ; Bind 78, Nr. 5. s. 1169-1203.
Bibtex
@article{44f723a2425b4d2d8a78c7de10fc722c,
title = "Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis",
abstract = "Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of {"}one-airway-one-disease,{"} coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the {"}Epithelial Barrier Hypothesis.{"} This review determined that the {"}one-airway-one-disease{"} concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme {"}allergic{"} (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.",
keywords = "Humans, Rhinitis/diagnosis, Asthma/diagnosis, Rhinitis, Allergic/complications, Allergens, Multimorbidity",
author = "J Bousquet and E Mel{\'e}n and T Haahtela and Koppelman, {G H} and A Togias and R Valenta and Akdis, {C A} and W Czarlewski and M Rothenberg and A Valiulis and M Wickman and M Akdis and D Aguilar and A Bedbrook and C Bindslev-Jensen and S Bosnic-Anticevich and Boulet, {L P} and Brightling, {C E} and L Brussino and E Burte and M Bustamante and Canonica, {G W} and L Cecchi and Celedon, {J C} and {Chaves Loureiro}, C and E Costa and Cruz, {A A} and M Erhola and B Gemicioglu and Fokkens, {W J} and J Garcia-Aymerich and S Guerra and J Heinrich and Ivancevich, {J C} and T Keil and L Klimek and P Kuna and M Kupczyk and V Kvedariene and Larenas-Linnemann, {D E} and N Lemonnier and {Lodrup Carlsen}, {K C} and R Louis and M Makela and M Makris and M Maurer and I Momas and M Morais-Almeida and J Mullol and Naclerio, {R N} and K Nadeau and R Nadif and M Niedoszytko and Y Okamoto and M Ollert and Papadopoulos, {N G} and G Passalacqua and V Patella and R Pawankar and N Pham-Thi and O Pfaar and Regateiro, {F S} and J Ring and Rouadi, {P W} and B Samolinski and J Sastre and M Savour{\'e} and N Scichilone and Shamji, {M H} and A Sheikh and V Siroux and B Sousa-Pinto and M Standl and J Sunyer and L Taborda-Barata and S Toppila-Salmi and Torres, {M J} and I Tsiligianni and E Valovirta and O Vandenplas and Ventura, {M T} and S Weiss and A Yorgancioglu and L Zhang and {Abdul Latiff}, {A H} and W Aberer and I Agache and M Al-Ahmad and I Alobid and Ansotegui, {I J} and Arshad, {S H} and E Asayag and C Barbara and A Baharudin and L Battur and Bennoor, {K S} and Berghea, {E C} and Bergmann, {K C} and D Bernstein and M Bewick and H Blain and M Bonini and F Braido and R Buhl and Bumbacea, {R S} and A Bush and M Calderon and M Calvo-Gil and P Camargos and L Caraballo and V Cardona and W Carr and P Carreiro-Martins and T Casale and {Cepeda Sarabia}, {A M} and R Chandrasekharan and D Charpin and Chen, {Y Z} and I Cherrez-Ojeda and T Chivato and E Chkhartishvili and G Christoff and Chu, {D K} and C Cingi and {Correia de Sousa}, J and C Corrigan and A Custovic and G D'Amato and {Del Giacco}, S and {De Blay}, F and P Devillier and A Didier and {do Ceu Teixeira}, M and D Dokic and H Douagui and M Doulaptsi and S Durham and M Dykewicz and T Eiwegger and El-Sayed, {Z A} and R Emuzyte and A Fiocchi and N Fyhrquist and Gomez, {R M} and M Gotua and Guzman, {M A} and J Hagemann and S Hamamah and S Halken and Halpin, {D M G} and M Hofmann and E Hossny and M Hrubi{\v s}ko and C Irani and Z Ispayeva and E Jares and T Jartti and E Jassem and K Julge and J Just and M Jutel and I Kaidashev and O Kalayci and Kalyoncu, {A F} and P Kardas and B Kirenga and H Kraxner and I Kull and M Kulus and {La Grutta}, S and S Lau and {Le Tuyet Thi}, L and M Levin and B Lipworth and O Louren{\c c}o and B Mahboub and E Martinez-Infante and P Matricardi and N Miculinic and N Migueres and F Mihaltan and Y Mohammad and M Moniuszko and S Montefort and H Neffen and K Nekam and E Nunes and {Nyembue Tshipukane}, D and R O'Hehir and I Ogulur and K Ohta and K Okubo and S Ouedraogo and H Olze and I Pali-Sch{\"o}ll and O Palomares and K Palosuo and C Panaitescu and P Panzner and Park, {H S} and C Pitsios and D Plavec and Popov, {T A} and F Puggioni and S Quirce and M Recto and Repka-Ramirez, {M S} and {Robalo Cordeiro}, C and N Roche and M Rodriguez-Gonzalez and J Romantowski and {Rosario Filho}, N and M Rottem and H Sagara and Serpa, {F S} and Z Sayah and S Scheire and P Schmid-Grendelmeier and Sisul, {J C} and D Sole and M Soto-Martinez and M Sova and A Sperl and O Spranger and R Stelmach and {Suppli Ulrik}, C and M Thomas and T To and A Todo-Bom and Tomazic, {P V} and M Urrutia-Pereira and M Valentin-Rostan and {Van Ganse}, E and {van Hage}, M and T Vasankari and P Vichyanond and G Viegi and D Wallace and Wang, {D Y} and S Williams and M Worm and P Yiallouros and O Yusuf and F Zaitoun and M Zernotti and M Zidarn and J Zuberbier and Fonseca, {J A} and T Zuberbier and Anto, {J M}",
note = "{\textcopyright} 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.",
year = "2023",
doi = "10.1111/all.15679",
language = "English",
volume = "78",
pages = "1169--1203",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",
number = "5",
}
RIS
TY - JOUR
T1 - Rhinitis associated with asthma is distinct from rhinitis alone
T2 - The ARIA-MeDALL hypothesis
AU - Bousquet, J
AU - Melén, E
AU - Haahtela, T
AU - Koppelman, G H
AU - Togias, A
AU - Valenta, R
AU - Akdis, C A
AU - Czarlewski, W
AU - Rothenberg, M
AU - Valiulis, A
AU - Wickman, M
AU - Akdis, M
AU - Aguilar, D
AU - Bedbrook, A
AU - Bindslev-Jensen, C
AU - Bosnic-Anticevich, S
AU - Boulet, L P
AU - Brightling, C E
AU - Brussino, L
AU - Burte, E
AU - Bustamante, M
AU - Canonica, G W
AU - Cecchi, L
AU - Celedon, J C
AU - Chaves Loureiro, C
AU - Costa, E
AU - Cruz, A A
AU - Erhola, M
AU - Gemicioglu, B
AU - Fokkens, W J
AU - Garcia-Aymerich, J
AU - Guerra, S
AU - Heinrich, J
AU - Ivancevich, J C
AU - Keil, T
AU - Klimek, L
AU - Kuna, P
AU - Kupczyk, M
AU - Kvedariene, V
AU - Larenas-Linnemann, D E
AU - Lemonnier, N
AU - Lodrup Carlsen, K C
AU - Louis, R
AU - Makela, M
AU - Makris, M
AU - Maurer, M
AU - Momas, I
AU - Morais-Almeida, M
AU - Mullol, J
AU - Naclerio, R N
AU - Nadeau, K
AU - Nadif, R
AU - Niedoszytko, M
AU - Okamoto, Y
AU - Ollert, M
AU - Papadopoulos, N G
AU - Passalacqua, G
AU - Patella, V
AU - Pawankar, R
AU - Pham-Thi, N
AU - Pfaar, O
AU - Regateiro, F S
AU - Ring, J
AU - Rouadi, P W
AU - Samolinski, B
AU - Sastre, J
AU - Savouré, M
AU - Scichilone, N
AU - Shamji, M H
AU - Sheikh, A
AU - Siroux, V
AU - Sousa-Pinto, B
AU - Standl, M
AU - Sunyer, J
AU - Taborda-Barata, L
AU - Toppila-Salmi, S
AU - Torres, M J
AU - Tsiligianni, I
AU - Valovirta, E
AU - Vandenplas, O
AU - Ventura, M T
AU - Weiss, S
AU - Yorgancioglu, A
AU - Zhang, L
AU - Abdul Latiff, A H
AU - Aberer, W
AU - Agache, I
AU - Al-Ahmad, M
AU - Alobid, I
AU - Ansotegui, I J
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N1 - © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
PY - 2023
Y1 - 2023
N2 - Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.
AB - Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.
KW - Humans
KW - Rhinitis/diagnosis
KW - Asthma/diagnosis
KW - Rhinitis, Allergic/complications
KW - Allergens
KW - Multimorbidity
U2 - 10.1111/all.15679
DO - 10.1111/all.15679
M3 - Review
C2 - 36799120
VL - 78
SP - 1169
EP - 1203
JO - Allergy: European Journal of Allergy and Clinical Immunology
JF - Allergy: European Journal of Allergy and Clinical Immunology
SN - 0105-4538
IS - 5
ER -