Restenosis in coronary bare metal stents. Importance of time to follow-up: a comparison of coronary angiograms 6 months and 4 years after implantation
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Restenosis in coronary bare metal stents. Importance of time to follow-up: a comparison of coronary angiograms 6 months and 4 years after implantation. / Jørgensen, Erik; Helqvist, Steffen; Kløvgaard, Lene; Kastrup, Jens; Clemmensen, Peter; Holmvang, Lene; Engstrøm, Thomas; Saunamaki, Kari; Kelbaek, Henning.
I: Scandinavian Cardiovascular Journal, Bind 43, Nr. 2, 2008, s. 87-93.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Restenosis in coronary bare metal stents. Importance of time to follow-up: a comparison of coronary angiograms 6 months and 4 years after implantation
AU - Jørgensen, Erik
AU - Helqvist, Steffen
AU - Kløvgaard, Lene
AU - Kastrup, Jens
AU - Clemmensen, Peter
AU - Holmvang, Lene
AU - Engstrøm, Thomas
AU - Saunamaki, Kari
AU - Kelbaek, Henning
N1 - Keywords: Aged; Angioplasty, Transluminal, Percutaneous Coronary; Coronary Angiography; Coronary Restenosis; Coronary Stenosis; Disease-Free Survival; Female; Humans; Hyperplasia; Kaplan-Meiers Estimate; Male; Metals; Middle Aged; Myocardial Infarction; Prosthesis Design; Remission, Spontaneous; Stents; Time Factors; Treatment Outcome
PY - 2008
Y1 - 2008
N2 - Objectives. Angiographic late lumen loss measured 6 to 9 month after bare metal stent implantation in the coronary arteries is a validated restenosis parameter. Design. We performed a second angiographic follow-up after 4 years in event free survivors from the DANSTENT trial cohort. Results. Quantitative comparison of paired coronary angiograms at 6 months and 4 years showed a reduction of late loss from 0.68+/-0.52mm to 0.42 (+/-0.52) (mean difference 0.26 (0.17 to 0.36), p<0.0001). Minimal instent lumen diameter had increased from 2.39+/-0.62mm to 2.64+/-0.56mm (mean difference: -0.24mm, 95% confidence interval: -0.34mm to -0.14mm, p<0.0001). Instent diameter stenosis decreased from 24.8+/-14.2% to 18.6+/-9.3% (mean difference 6.16%, 95% confidence interval: 2.82 to 9.48%, p=0.0006). This observed spontaneous decrease of instent restenosis corresponds to a 19% increase of minimal cross-sectional vessel area and a 39% reduction of the binary restenosis rate over time. Conclusions. Instent late lumen loss in bare metal stents decreases spontaneously over time. Maturation of early hyperplastic tissue reaction after stent implantation with subsequent thinning of fibrotic tissue might explain this phenomenon Udgivelsesdato: 2008/11/23
AB - Objectives. Angiographic late lumen loss measured 6 to 9 month after bare metal stent implantation in the coronary arteries is a validated restenosis parameter. Design. We performed a second angiographic follow-up after 4 years in event free survivors from the DANSTENT trial cohort. Results. Quantitative comparison of paired coronary angiograms at 6 months and 4 years showed a reduction of late loss from 0.68+/-0.52mm to 0.42 (+/-0.52) (mean difference 0.26 (0.17 to 0.36), p<0.0001). Minimal instent lumen diameter had increased from 2.39+/-0.62mm to 2.64+/-0.56mm (mean difference: -0.24mm, 95% confidence interval: -0.34mm to -0.14mm, p<0.0001). Instent diameter stenosis decreased from 24.8+/-14.2% to 18.6+/-9.3% (mean difference 6.16%, 95% confidence interval: 2.82 to 9.48%, p=0.0006). This observed spontaneous decrease of instent restenosis corresponds to a 19% increase of minimal cross-sectional vessel area and a 39% reduction of the binary restenosis rate over time. Conclusions. Instent late lumen loss in bare metal stents decreases spontaneously over time. Maturation of early hyperplastic tissue reaction after stent implantation with subsequent thinning of fibrotic tissue might explain this phenomenon Udgivelsesdato: 2008/11/23
U2 - 10.1080/14017430802582602
DO - 10.1080/14017430802582602
M3 - Journal article
C2 - 19031301
VL - 43
SP - 87
EP - 93
JO - Scandinavian Cardiovascular Journal
JF - Scandinavian Cardiovascular Journal
SN - 1401-7458
IS - 2
ER -
ID: 10905026