Reprogramming chromatin

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Reprogramming chromatin. / Ehrensberger, Andreas Hasso; Svejstrup, Jesper Qualmann.

I: Critical Reviews in Biochemistry and Molecular Biology, Bind 47, Nr. 5, 09.2012, s. 464-482.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ehrensberger, AH & Svejstrup, JQ 2012, 'Reprogramming chromatin', Critical Reviews in Biochemistry and Molecular Biology, bind 47, nr. 5, s. 464-482. https://doi.org/10.3109/10409238.2012.697125

APA

Ehrensberger, A. H., & Svejstrup, J. Q. (2012). Reprogramming chromatin. Critical Reviews in Biochemistry and Molecular Biology, 47(5), 464-482. https://doi.org/10.3109/10409238.2012.697125

Vancouver

Ehrensberger AH, Svejstrup JQ. Reprogramming chromatin. Critical Reviews in Biochemistry and Molecular Biology. 2012 sep.;47(5):464-482. https://doi.org/10.3109/10409238.2012.697125

Author

Ehrensberger, Andreas Hasso ; Svejstrup, Jesper Qualmann. / Reprogramming chromatin. I: Critical Reviews in Biochemistry and Molecular Biology. 2012 ; Bind 47, Nr. 5. s. 464-482.

Bibtex

@article{b8265bdc859e4fd0b7070768216ceafb,
title = "Reprogramming chromatin",
abstract = "Cellular reprogramming involves the artificial dedifferentiation of somatic cells to a pluripotent state. When affected by overexpressing specific transcription factors, the process is highly inefficient, as only 0.1-1% of cells typically undergo the transformation. This low efficiency has been attributed to high kinetic barriers that affect all cells equally and can only be overcome by rare stochastic events. The barriers to reprogramming are likely to involve transformations of chromatin state because (i) inhibitors of chromatin-modifying enzymes can enhance the efficiency of reprogramming and (ii) knockdown or knock-out of chromatin-modifying enzymes can lower the efficiency of reprogramming. Here, we review the relationship between chromatin state transformations (chromatin reprogramming) and cellular reprogramming, with an emphasis on transcription factors, chromatin remodeling factors, histone modifications and DNA methylation.",
author = "Ehrensberger, {Andreas Hasso} and Svejstrup, {Jesper Qualmann}",
year = "2012",
month = sep,
doi = "10.3109/10409238.2012.697125",
language = "English",
volume = "47",
pages = "464--482",
journal = "Critical Reviews in Biochemistry and Molecular Biology",
issn = "1040-9238",
publisher = "Taylor & Francis",
number = "5",

}

RIS

TY - JOUR

T1 - Reprogramming chromatin

AU - Ehrensberger, Andreas Hasso

AU - Svejstrup, Jesper Qualmann

PY - 2012/9

Y1 - 2012/9

N2 - Cellular reprogramming involves the artificial dedifferentiation of somatic cells to a pluripotent state. When affected by overexpressing specific transcription factors, the process is highly inefficient, as only 0.1-1% of cells typically undergo the transformation. This low efficiency has been attributed to high kinetic barriers that affect all cells equally and can only be overcome by rare stochastic events. The barriers to reprogramming are likely to involve transformations of chromatin state because (i) inhibitors of chromatin-modifying enzymes can enhance the efficiency of reprogramming and (ii) knockdown or knock-out of chromatin-modifying enzymes can lower the efficiency of reprogramming. Here, we review the relationship between chromatin state transformations (chromatin reprogramming) and cellular reprogramming, with an emphasis on transcription factors, chromatin remodeling factors, histone modifications and DNA methylation.

AB - Cellular reprogramming involves the artificial dedifferentiation of somatic cells to a pluripotent state. When affected by overexpressing specific transcription factors, the process is highly inefficient, as only 0.1-1% of cells typically undergo the transformation. This low efficiency has been attributed to high kinetic barriers that affect all cells equally and can only be overcome by rare stochastic events. The barriers to reprogramming are likely to involve transformations of chromatin state because (i) inhibitors of chromatin-modifying enzymes can enhance the efficiency of reprogramming and (ii) knockdown or knock-out of chromatin-modifying enzymes can lower the efficiency of reprogramming. Here, we review the relationship between chromatin state transformations (chromatin reprogramming) and cellular reprogramming, with an emphasis on transcription factors, chromatin remodeling factors, histone modifications and DNA methylation.

U2 - 10.3109/10409238.2012.697125

DO - 10.3109/10409238.2012.697125

M3 - Journal article

C2 - 22757592

VL - 47

SP - 464

EP - 482

JO - Critical Reviews in Biochemistry and Molecular Biology

JF - Critical Reviews in Biochemistry and Molecular Biology

SN - 1040-9238

IS - 5

ER -

ID: 38419025