Reproductive history and prognosis of primary breast cancer
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Reproductive history and prognosis of primary breast cancer. / Kroman, Niels T.; Mouridsen, Henning; Melbye, Mads.
I: Ugeskrift for Laeger, Bind 163, Nr. 38, 17.09.2001, s. 5208-5209.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Reproductive history and prognosis of primary breast cancer
AU - Kroman, Niels T.
AU - Mouridsen, Henning
AU - Melbye, Mads
PY - 2001/9/17
Y1 - 2001/9/17
N2 - The aetiological impact of a woman's reproductive history on breast cancer is well established, whereas the prognostic influence of the reproductive pattern is less well described. A literature search with focus on three Danish studies is described. Status as parous/nulliparous and number of births appear to have no prognostic influence. Women who have their first child at an early age have a lower survival than women who have postponed their first childbirth. This may eventually be explained by selection, i.e. that women with an early first full-term pregnancy represent a group with a more malignant disease. Women diagnosed in the first two years after childbirth have a significantly lower survival, probably because the cancer, being subclinical during pregnancy, is affected by the high oestrogen concentrations with aggressive growth as the outcome. Pregnancy after treatment of breast cancer does not appear to have a negative influence on the prognosis.
AB - The aetiological impact of a woman's reproductive history on breast cancer is well established, whereas the prognostic influence of the reproductive pattern is less well described. A literature search with focus on three Danish studies is described. Status as parous/nulliparous and number of births appear to have no prognostic influence. Women who have their first child at an early age have a lower survival than women who have postponed their first childbirth. This may eventually be explained by selection, i.e. that women with an early first full-term pregnancy represent a group with a more malignant disease. Women diagnosed in the first two years after childbirth have a significantly lower survival, probably because the cancer, being subclinical during pregnancy, is affected by the high oestrogen concentrations with aggressive growth as the outcome. Pregnancy after treatment of breast cancer does not appear to have a negative influence on the prognosis.
UR - http://www.scopus.com/inward/record.url?scp=0040750657&partnerID=8YFLogxK
M3 - Journal article
C2 - 11577528
AN - SCOPUS:0040750657
VL - 163
SP - 5208
EP - 5209
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 38
ER -
ID: 259822266