Repeat transcatheter aortic valve implantation and implications for transcatheter heart valve performance: Insights from bench testing
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Repeat transcatheter aortic valve implantation and implications for transcatheter heart valve performance : Insights from bench testing. / Sathananthan, Janarthanan; Fraser, Rob; Landes, Uri; Rich, Courtney; Sellers, Stephanie; Leipsic, Jonathan; Blanke, Philipp; Lutter, Georg; Frank, Derk; Puehler, Thomas; Wood, David A.; Søndergaard, Lars; Webb, John G.
I: EuroIntervention, Bind 17, Nr. 10, 2021, s. 856-864.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Repeat transcatheter aortic valve implantation and implications for transcatheter heart valve performance
T2 - Insights from bench testing
AU - Sathananthan, Janarthanan
AU - Fraser, Rob
AU - Landes, Uri
AU - Rich, Courtney
AU - Sellers, Stephanie
AU - Leipsic, Jonathan
AU - Blanke, Philipp
AU - Lutter, Georg
AU - Frank, Derk
AU - Puehler, Thomas
AU - Wood, David A.
AU - Søndergaard, Lars
AU - Webb, John G
N1 - Publisher Copyright: © Europa Digital & Publishing 2021.
PY - 2021
Y1 - 2021
N2 - Background: THV implantation within failed surgical valves is well established. However, the implications of THV implantation within failed THVs are poorly understood. Aims: This study aimed to assess the impact of different transcatheter heart valve (THV) designs and implant positioning strategies on hydrodynamic performance after redo transcatheter aortic valve implantation (TAVI). Methods: THVs of varying design (SAPIEN 3, Evolut PRO, ACURATE neo, ALLEGRA, and Portico) and size were implanted inside SAPIEN XT and Evolut R THVs. Hydrodynamic function as per International Organization for Standardization (ISO) specifications was evaluated using a pulse duplicator, and multimodality imaging was performed. Results: The majority of tested THV-in-THV combinations resulted in stable anchoring of the new implant. However, some combinations resulted in unstable anchoring with the potential for dislodgement or embolisation. Hydrodynamic function was favourable for all tested THV designs implanted in the intraannular SAPIEN XT THV. SAPIEN 3 implantation within an Evolut THV with supra-annular leaflets must be appropriately sized to ensure adequate anchoring. Avoidance of an intra-annular deployment mitigated leaflet overhang of the Evolut leaflets and optimised hydrodynamic performance. Conclusions: This study demonstrates that most THV designs and implantation strategies can result in favourable hydrodynamic performance following redo TAVI. Whether the leaflets of a failed THV are intraor supra-annular may have important implications for the positioning of a redo-THV implant. Certain THV designs or implantation positions may be more desirable when performing redo TAVI.
AB - Background: THV implantation within failed surgical valves is well established. However, the implications of THV implantation within failed THVs are poorly understood. Aims: This study aimed to assess the impact of different transcatheter heart valve (THV) designs and implant positioning strategies on hydrodynamic performance after redo transcatheter aortic valve implantation (TAVI). Methods: THVs of varying design (SAPIEN 3, Evolut PRO, ACURATE neo, ALLEGRA, and Portico) and size were implanted inside SAPIEN XT and Evolut R THVs. Hydrodynamic function as per International Organization for Standardization (ISO) specifications was evaluated using a pulse duplicator, and multimodality imaging was performed. Results: The majority of tested THV-in-THV combinations resulted in stable anchoring of the new implant. However, some combinations resulted in unstable anchoring with the potential for dislodgement or embolisation. Hydrodynamic function was favourable for all tested THV designs implanted in the intraannular SAPIEN XT THV. SAPIEN 3 implantation within an Evolut THV with supra-annular leaflets must be appropriately sized to ensure adequate anchoring. Avoidance of an intra-annular deployment mitigated leaflet overhang of the Evolut leaflets and optimised hydrodynamic performance. Conclusions: This study demonstrates that most THV designs and implantation strategies can result in favourable hydrodynamic performance following redo TAVI. Whether the leaflets of a failed THV are intraor supra-annular may have important implications for the positioning of a redo-THV implant. Certain THV designs or implantation positions may be more desirable when performing redo TAVI.
KW - Aortic stenosis
KW - TAVI
KW - Valve-in-valve
U2 - 10.4244/EIJ-D-20-00697
DO - 10.4244/EIJ-D-20-00697
M3 - Journal article
C2 - 33495142
AN - SCOPUS:85108068679
VL - 17
SP - 856
EP - 864
JO - EuroIntervention
JF - EuroIntervention
SN - 1774-024X
IS - 10
ER -
ID: 301698642