Renal hyperfiltration as a novel marker of all-cause mortality
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Renal hyperfiltration as a novel marker of all-cause mortality. / Park, Minseon; Yoon, Eunsil; Lim, Youn-Hee; Kim, Ho; Choi, Jinwook; Yoon, Hyung-Jin.
I: Journal of the American Society of Nephrology, Bind 26, Nr. 6, 2015, s. 1426-1433.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Renal hyperfiltration as a novel marker of all-cause mortality
AU - Park, Minseon
AU - Yoon, Eunsil
AU - Lim, Youn-Hee
AU - Kim, Ho
AU - Choi, Jinwook
AU - Yoon, Hyung-Jin
N1 - Copyright © 2015 by the American Society of Nephrology.
PY - 2015
Y1 - 2015
N2 - Although renal hyperfiltration (RHF) or an abnormal increase in GFR has been associated with many lifestyles and clinical conditions, including diabetes, its clinical consequence is not clear. RHF is frequently considered to be the result of overestimating true GFR in subjects with muscle wasting. To evaluate the association between RHF and mortality, 43,503 adult Koreans who underwent voluntary health screening at Seoul National University Hospital between March of 1995 and May of 2006 with baseline GFR≥60 ml/min per 1.73 m(2) were followed up for mortality until December 31, 2012. GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration creatinine equation, and RHF was defined as GFR>95th percentile after adjustment for age, sex, muscle mass, and history of diabetes and/or hypertension medication. Muscle mass was measured with bioimpedance analysis at baseline. During the median follow-up of 12.4 years, 1743 deaths occurred. The odds ratio of RHF in participants with the highest quartile of muscle mass was 1.31 (95% confidence interval [95% CI], 1.11 to 1.54) compared with the lowest quartile after adjusting for confounding factors, including body mass index. The hazard ratio of all-cause mortality for RHF was 1.37 (95% CI, 1.11 to 1.70) by Cox proportional hazards model with adjustment for known risk factors, including smoking. These data suggest RHF may be associated with increased all-cause mortality in an apparently healthy population. The possibility of RHF as a novel marker of all-cause mortality should be confirmed.
AB - Although renal hyperfiltration (RHF) or an abnormal increase in GFR has been associated with many lifestyles and clinical conditions, including diabetes, its clinical consequence is not clear. RHF is frequently considered to be the result of overestimating true GFR in subjects with muscle wasting. To evaluate the association between RHF and mortality, 43,503 adult Koreans who underwent voluntary health screening at Seoul National University Hospital between March of 1995 and May of 2006 with baseline GFR≥60 ml/min per 1.73 m(2) were followed up for mortality until December 31, 2012. GFR was estimated with the Chronic Kidney Disease Epidemiology Collaboration creatinine equation, and RHF was defined as GFR>95th percentile after adjustment for age, sex, muscle mass, and history of diabetes and/or hypertension medication. Muscle mass was measured with bioimpedance analysis at baseline. During the median follow-up of 12.4 years, 1743 deaths occurred. The odds ratio of RHF in participants with the highest quartile of muscle mass was 1.31 (95% confidence interval [95% CI], 1.11 to 1.54) compared with the lowest quartile after adjusting for confounding factors, including body mass index. The hazard ratio of all-cause mortality for RHF was 1.37 (95% CI, 1.11 to 1.70) by Cox proportional hazards model with adjustment for known risk factors, including smoking. These data suggest RHF may be associated with increased all-cause mortality in an apparently healthy population. The possibility of RHF as a novel marker of all-cause mortality should be confirmed.
KW - Adult
KW - Age Factors
KW - Aged
KW - Anthropometry
KW - Body Mass Index
KW - Cause of Death
KW - Comorbidity
KW - Female
KW - Glomerular Filtration Rate
KW - Humans
KW - Incidence
KW - Kidney Glomerulus/metabolism
KW - Life Style
KW - Male
KW - Mass Screening/methods
KW - Middle Aged
KW - Odds Ratio
KW - Proportional Hazards Models
KW - Renal Insufficiency, Chronic/mortality
KW - Republic of Korea
KW - Retrospective Studies
KW - Risk Factors
KW - Severity of Illness Index
KW - Sex Factors
KW - Smoking/epidemiology
KW - Survival Analysis
U2 - 10.1681/ASN.2014010115
DO - 10.1681/ASN.2014010115
M3 - Journal article
C2 - 25343954
VL - 26
SP - 1426
EP - 1433
JO - Journal of the American Society of Nephrology : JASN
JF - Journal of the American Society of Nephrology : JASN
SN - 1046-6673
IS - 6
ER -
ID: 230071078