Regulation of p21ras activity.
Publikation: Bidrag til tidsskrift › Review › Forskning
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Regulation of p21ras activity. / Lowy, D R; Zhang, K; DeClue, J E; Willumsen, B M.
I: Trends in Genetics, Bind 7, Nr. 11-12, 1992, s. 346-51.Publikation: Bidrag til tidsskrift › Review › Forskning
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TY - JOUR
T1 - Regulation of p21ras activity.
AU - Lowy, D R
AU - Zhang, K
AU - DeClue, J E
AU - Willumsen, B M
N1 - Keywords: Amino Acid Sequence; Animals; Fungal Proteins; GTPase-Activating Proteins; Gene Expression Regulation; Guanosine Diphosphate; Guanosine Triphosphate; Humans; Mammals; Models, Biological; Molecular Sequence Data; Neurofibromin 1; Phosphorylation; Protein Processing, Post-Translational; Proteins; Proto-Oncogene Proteins p21(ras); Saccharomyces cerevisiae; Signal Transduction; ras GTPase-Activating Proteins; ras Proteins
PY - 1992
Y1 - 1992
N2 - The ras genes encode GTP/GDP-binding proteins that participate in mediating mitogenic signals from membrane tyrosine kinases to downstream targets. The activity of p21ras is determined by the concentration of GTP-p21ras, which is tightly regulated by a complex array of positive and negative control mechanisms. GAP and NF1 can negatively regulate p21ras activity by stimulating hydrolysis of GTP bound to p21ras. Other cellular factors can positively regulate p21ras by stimulating GDP/GTP exchange.
AB - The ras genes encode GTP/GDP-binding proteins that participate in mediating mitogenic signals from membrane tyrosine kinases to downstream targets. The activity of p21ras is determined by the concentration of GTP-p21ras, which is tightly regulated by a complex array of positive and negative control mechanisms. GAP and NF1 can negatively regulate p21ras activity by stimulating hydrolysis of GTP bound to p21ras. Other cellular factors can positively regulate p21ras by stimulating GDP/GTP exchange.
M3 - Review
C2 - 1820685
VL - 7
SP - 346
EP - 351
JO - Trends in Genetics
JF - Trends in Genetics
SN - 0168-9525
IS - 11-12
ER -
ID: 2890841